角化細胞
ケラチノサイト
(角化細胞： から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/04/07 08:00 UTC 版)
ケラチノサイトまたは角化細胞（かくかさいぼう、英: keratinocyte）は皮膚の最外層の表皮に存在する主要な細胞であり、ヒトでは表皮の細胞の90％を占める[1]。表皮の基底層（stratum basale）に位置する基底細胞は、基底ケラチノサイトまたは基底角化細胞（basal keratinocyte）とも呼ばれる[2]。
- ^ McGrath JA; Eady RAJ; Pope FM. (2004). “Anatomy and Organization of Human Skin”. In Burns T; Breathnach S; Cox N et al.. Rook's Textbook of Dermatology (7th ed.). Blackwell Publishing. p. 4190. doi:10.1002/9780470750520.ch3. ISBN 978-0-632-06429-8 2010年6月1日閲覧。
- ^ Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. (December 2005). pp. 5–6. ISBN 978-0-7216-2921-6. オリジナルの2010-10-11時点におけるアーカイブ。 2010年6月1日閲覧。
- ^ Murphy, Kenneth (Kenneth M.) (2017). Janeway's immunobiology. Weaver, Casey (Ninth ed.). New York, NY, USA. p. 112. ISBN 9780815345053. OCLC 933586700
- ^ Gilbert, Scott F. (2000). “The Epidermis and the Origin of Cutaneous Structures.”. Developmental Biology.. Sinauer Associates. ISBN 978-0878932436. "Throughout life, the dead keratinized cells of the cornified layer are shed (humans lose about 1.5 grams of these cells each day*) and are replaced by new cells, the source of which is the mitotic cells of the Malpighian layer. Pigment cells (melanocytes) from the neural crest also reside in the Malpighian layer, where they transfer their pigment sacs (melanosomes) to the developing keratinocytes."
- ^ “A keratinocyte's course of life”. Skin Pharmacology and Physiology 20 (3): 122–32. (2007). doi:10.1159/000098163. PMID 17191035.
- ^ “Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin”. The EMBO Journal 20 (6): 1215–22. (March 2001). doi:10.1093/emboj/20.6.1215. PMC 145528. PMID 11250888.
- ^ Koster MI (July 2009). “Making an epidermis”. Annals of the New York Academy of Sciences 1170 (1): 7–10. Bibcode: 2009NYASA1170....7K. doi:10.1111/j.1749-6632.2009.04363.x. PMC 2861991. PMID 19686098.
- ^ Halprin KM (January 1972). “Epidermal "turnover time"--a re-examination”. The British Journal of Dermatology 86 (1): 14–9. doi:10.1111/j.1365-2133.1972.tb01886.x. PMID 4551262.
- ^ “Measurement of the transit time for cells through the epidermis and stratum corneum of the mouse and guinea-pig”. Cell and Tissue Kinetics 20 (5): 461–72. (September 1987). doi:10.1111/j.1365-2184.1987.tb01355.x. PMID 3450396.
- ^ “The skin: an indispensable barrier”. Experimental Dermatology 17 (12): 1063–72. (December 2008). doi:10.1111/j.1600-0625.2008.00786.x. PMID 19043850.
- ^ “Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes”. Carcinogenesis 10 (4): 777–80. (April 1989). doi:10.1093/carcin/10.4.777. PMID 2702726.
- ^ “Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3”. Journal of Cellular Physiology 146 (1): 94–100. (January 1991). doi:10.1002/jcp.1041460113. PMID 1990023.
- ^ Reiss, M; Lipsey, LR; Zhou, ZL (1991). “Extracellular calcium-dependent regulation of transmembrane calcium fluxes in murine keratinocytes”. Journal of Cellular Physiology 147 (2): 281–91. doi:10.1002/jcp.1041470213. PMID 1645742.
- ^ Mauro, TM; Pappone, PA; Isseroff, RR (1990). “Extracellular calcium affects the membrane currents of cultured human keratinocytes”. Journal of Cellular Physiology 143 (1): 13–20. doi:10.1002/jcp.1041430103. PMID 1690740.
- ^ Mauro, TM; Isseroff, RR; Lasarow, R; Pappone, PA (1993). “Ion channels are linked to differentiation in keratinocytes”. The Journal of Membrane Biology 132 (3): 201–9. doi:10.1007/BF00235738. PMID 7684087.
- ^ Tu, CL; Oda, Y; Bikle, DD (1999). “Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes”. The Journal of Investigative Dermatology 113 (3): 340–5. doi:10.1046/j.1523-1747.1999.00698.x. PMID 10469331.
- ^ Hennings, Henry; Michael, Delores; Cheng, Christina; Steinert, Peter; Holbrook, Karen; Yuspa, Stuart H. (1980). “Calcium regulation of growth and differentiation of mouse epidermal cells in culture”. Cell 19 (1): 245–54. doi:10.1016/0092-8674(80)90406-7. PMID 6153576.
- ^ Su, MJ; Bikle, DD; Mancianti, ML; Pillai, S (1994). “1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium”. The Journal of Biological Chemistry 269 (20): 14723–9. PMID 7910167.
- ^ Fu, G. K.; Lin, D; Zhang, MY; Bikle, DD; Shackleton, CH; Miller, WL; Portale, AA (1997). “Cloning of Human 25-Hydroxyvitamin D-1 -Hydroxylase and Mutations Causing Vitamin D-Dependent Rickets Type 1”. Molecular Endocrinology 11 (13): 1961–70. doi:10.1210/me.11.13.1961. PMID 9415400.
- ^ Kawakubo, Tomoyo; Yasukochi, Atsushi; Okamoto, Kuniaki; Okamoto, Yoshiko; Nakamura, Seiji; Yamamoto, Kenji (2011). “The role of cathepsin E in terminal differentiation of keratinocytes”. Biological Chemistry 392 (6): 571–85. doi:10.1515/BC.2011.060. hdl:2324/25561. PMID 21521076.
- ^ Jackson, B.; Brown, S. J.; Avilion, A. A.; O'Shaughnessy, R. F. L.; Sully, K.; Akinduro, O.; Murphy, M.; Cleary, M. L. et al. (2011). “TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier”. Journal of Cell Science 124 (10): 1681–1690. doi:10.1242/jcs.077552. PMC 3183491. PMID 21511732.
- ^ a b Rheinwald, JG; Green, H (1975). “Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells”. Cell 6 (3): 331–43. doi:10.1016/S0092-8674(75)80001-8. PMID 1052771.
- ^ Truong, AB; Kretz, M; Ridky, TW; Kimmel, R; Khavari, PA (2006). “P63 regulates proliferation and differentiation of developmentally mature keratinocytes”. Genes & Development 20 (22): 3185–97. doi:10.1101/gad.1463206. PMC 1635152. PMID 17114587.
- ^ Fuchs, E; Green, H (1981). “Regulation of terminal differentiation of cultured human keratinocytes by vitamin A”. Cell 25 (3): 617–25. doi:10.1016/0092-8674(81)90169-0. PMID 6169442.
- ^ Rheinwald, JG; Green, H (1977). “Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes”. Nature 265 (5593): 421–4. Bibcode: 1977Natur.265..421R. doi:10.1038/265421a0. PMID 299924.
- ^ Barrandon, Y; Green, H (1987). “Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-alpha and epidermal growth factor”. Cell 50 (7): 1131–7. doi:10.1016/0092-8674(87)90179-6. PMID 3497724.
- ^ Brenner M; Hearing VJ. (May–June 2008). “The Protective Role of Melanin Against UV Damage in Human Skin”. Photochemistry and Photobiology 84 (3): 539–549. doi:10.1111/j.1751-1097.2007.00226.x. PMC 2671032. PMID 18435612.
- ^ Ito, M; Liu, Y; Yang, Z; Nguyen, J; Liang, F; Morris, RJ; Cotsarelis, G (2005). “Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis”. Nature Medicine 11 (12): 1351–4. doi:10.1038/nm1328. PMID 16288281.
- ^ Claudinot, S; Nicolas, M; Oshima, H; Rochat, A; Barrandon, Y (2005). “Long-term renewal of hair follicles from clonogenic multipotent stem cells”. Proceedings of the National Academy of Sciences of the United States of America 102 (41): 14677–82. Bibcode: 2005PNAS..10214677C. doi:10.1073/pnas.0507250102. PMC 1253596. PMID 16203973.
- ^ Ito, M; Yang, Z; Andl, T; Cui, C; Kim, N; Millar, SE; Cotsarelis, G (2007). “Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding”. Nature 447 (7142): 316–20. Bibcode: 2007Natur.447..316I. doi:10.1038/nature05766. PMID 17507982.
- ^ Shen, Yue; Guo, Yongzhi; Du, Chun; Wilczynska, Malgorzata; Hellström, Sten; Ny, Tor (2012). “Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations”. PloS One 7 (12): e51303. doi:10.1371/journal.pone.0051303. ISSN 1932-6203. PMC 3517469. PMID 23236466.
- ^ Young AR (June 1987). “The sunburn cell”. Photodermatology 4 (3): 127–134. PMID 3317295.
- ^ “The sunburn cell revisited: an update on mechanistic aspects”. Photochemical and Photobiological Sciences 1 (6): 365–377. (June 2002). doi:10.1039/b108291d. PMID 12856704.
- ^ a b “Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells”. Proc. Natl. Acad. Sci. U.S.A. 112 (33): 10407–12. (August 2015). Bibcode: 2015PNAS..11210407V. doi:10.1073/pnas.1505675112. PMC 4547253. PMID 26240345.
- ^ Crissey, John Thorne; Parish, Lawrence C.; Holubar, Karl (2002). Historical Atlas of Dermatology and Dermatologists. Boca Raton, FL: CRC Press. p. 147. ISBN 1-84214-100-7
- ^ a b c Seema, Chhabra; Pranay, Tanwar; Kumar, AroraSandeep (2013). “Civatte bodies: A diagnostic clue”. Indian Journal of Dermatology 58 (4): 327. doi:10.4103/0019-5154.113974. ISSN 0019-5154. PMC 3726905. PMID 23919028.
[続きの解説]
「ケラチノサイト」の続きの解説一覧
- 1 ケラチノサイトとは
- 2 ケラチノサイトの概要
- 3 創傷治癒における役割
- 4 関連文献
角化細胞：
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/08/11 05:34 UTC 版)
ヒト脂肪組織由来Muse細胞は、ゼラチンコートディッシュ上で自発的に、もしくはBMP4やall-trans-Retinoic acidなどのサイトカイン処理により角化細胞へと分化する。
※この「角化細胞：」の解説は、「ミューズ細胞」の解説の一部です。
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