グルタミノリシス
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2017/06/14 03:31 UTC 版)
グルタミノリシス（Glutaminolysis）あるいはグルタミン分解は、アミノ酸のグルタミンをグルタミン酸やアスパラギン酸、CO2、ピルビン酸、乳酸、アラニン、クエン酸へと分解する一連の生化学反応である[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]。
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- ^ a b c Moreadith RW, RW; Lehninger AL (1984). “The pathways of glutamate and glutamine oxidation by tumor cell mitochondria”. J. Biol. Chem. 259 (10): 6215–6221. PMID 6144677.
- ^ a b Zielke, HR; Zielke CL and Ozand PT (1984). “Glutamine: a major energy source for cultured mammalian cells”. Fed. Proc. 43 (1): 121–125. PMID 6690331.
- ^ a b Eigenbrodt, E; Fister P, Reinacher M (1985). “New perspectives on carbohydrate metabolism in tumor cells”. In: Regulation of Carbohydrate Metabolism, CRC Press, Boca Raton, Fl 2: 141–179. ISBN 0-8493-5263-0.
- ^ a b Lanks, KW (1987). “End products of glucose and glutamine metabolism by L929 cells”. J. Biol. Chem. 262 (21): 10093–10097. PMID 3611053.
- ^ a b Board, M; Humm S and Newsholme EA (1990). “Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells”. Biochem. J. 265 (2): 503–509. PMC 1136912. PMID 2302181.
- ^ a b Medina, MA; Nunez de Castro I (1990). “Glutaminolysis and glycolysis interactions in proliferant cells”. Int. J. Biochem. 22 (7): 681–683. doi:10.1016/0020-711X(90)90001-J. PMID 2205518.
- ^ a b Goossens, V; Grooten J and Fiers W (1996). “The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells”. J. Biol. Chem. 271 (1): 192–196. doi:10.1074/jbc.271.1.192. PMID 8550558.
- ^ a b Mazurek, S; Michel A and Eigenbrodt E (1997). “Effect of extracellular AMP on cell proliferation and metabolism of breast cancer cell lines with high and low glycolytic rates”. J. Biol. Chem. 272 (8): 4941–4952. doi:10.1074/jbc.272.8.4941. PMID 9030554.
- ^ a b Eigenbrodt, E; Kallinowski F, Ott M, Mazurek S and Vaupel P (1998). “Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors”. Anticancer Res. 18 (5A): 3267–3274. PMID 9858894.
- ^ a b Piva, TJ; McEvoy-Bowe E (1998). “Oxidation of glutamine in HeLa cells: role and control of truncated TCA cycles in tumour mitochondria”. J. Cell Biochem. 68 (2): 213–225. doi:10.1002/(SICI)1097-4644(19980201)68:2<213::AID-JCB8>3.0.CO;2-Y. PMID 9443077.
- ^ Mazurek, S; Eigenbrodt E, Failing K and Steinberg P (1999). “Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells”. J. Cell. Physiol. 181 (1): 136–146. doi:10.1002/(SICI)1097-4652(199910)181:1<136::AID-JCP14>3.0.CO;2-T. PMID 10457361.
- ^ a b Mazurek, S; Zwerschke W, Jansen-Dürr P and Eigenbrodt E (2001). “Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyuvate kinase type M2 and the glycolytic enzyme complex”. Biochem. J. 356 (Pt 1): 247–256. doi:10.1042/0264-6021:3560247. PMC 1221834. PMID 11336658.
- ^ a b Aledo, JC (2004). “Glutamine breakdown in rapidly dividing cells: waste or investment ?”. BioEssays 26 (7): 778–785. doi:10.1002/bies.20063. PMID 15221859.
- ^ a b Rossignol, R; Gilkerson R, Aggeler R, Yamagata K, Remington SJ and Capaldi RA (2004). “Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells”. Cancer Res. 64 (3): 985–993. doi:10.1158/0008-5472.CAN-03-1101. PMID 14871829.
- ^ a b Mazurek, S (2007). “Tumor cell energetic metabolome”. In: Molecular System Bioenergetics (Saks, V ed.) Wiley-VCH, Weinheim, Germany: 521–540. ISBN 978-3-527-31787-5.
- ^ DeBerardinis, RJ; Sayed N, Ditsworth D, Thompson CB (2008). “Brick by brick: metabolism and tumor growth”. Curr. Op. Gen. Dev. 18 (1): 54–61. doi:10.1016/j.gde.2008.02.003. PMC 2476215. PMID 18387799.
- ^ Wolfrom, C; Kadhom N, Polini G, Poggi J, Moatti N and Gautier M (1989). “Glutamine dependency of human skin fibroblasts: modulation of hexoses”. Exp. Cell Res. 183 (2): 303–318. doi:10.1016/0014-4827(89)90391-1. PMID 2767153.
- ^ Gardner, PR; Raineri I, Epstein LB and White CW (1995). “Superoxide radical and iron modulate aconitase activity in mammalian cells”. J. Biol. Chem. 270 (22): 13399–13405. doi:10.1074/jbc.270.22.13399. PMID 7768942.
- ^ Kim, KH; Rodriguez AM, Carrico PM and Melendez JA (2001). “Potential mechanisms for the inhibition of tumor cell growth by manganese superoxide dismutase”. Antioxid. Redox. Signal. 3 (3): 361–373. doi:10.1089/15230860152409013. PMID 11491650.
- ^ Matsuno, T; Goto I (1992). “Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma”. Cancer Res. 52 (5): 1192–1194. PMID 1346587.
- ^ Aledo, JC; Segura JA, Medina MA, Alonso FJ, Nunez de Castro I and Marquez J (1994). “Phosphate-activated glutaminase expression during tumor development”. FEBS Lett. 341 (1): 39–42. doi:10.1016/0014-5793(94)80236-X. PMID 8137919.
- ^ a b Lobo, C; Ruiz-Bellido MA, Aledo JC, Marquez J, Nunez De Castro I and Alonso FJ (2000). “Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells”. Biochem. J. 348 (2): 257–261. doi:10.1042/0264-6021:3480257. PMC 1221061. PMID 10816417.
- ^ Mazurek, S; Grimm H, Oehmke M, Weisse G, Teigelkamp S and Eigenbrodt E (2000). “Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells”. Anticancer Res. 20 (6D): 5151–5154. PMID 11326687.
- ^ Turowski, GA; Rashid Z, Hong F, Madri JA and Basson MD (1994). “Glutamine modulates phenotype and stimulates proliferation in human colon cancer cell lines”. Cancer Res. 54 (22): 5974–5980. PMID 7954430.
- ^ Spittler, A; Oehler R, Goetzinger P, Holzer S, Reissner CM, Leutmezer J, Rath V, Wrba F, Fuegger R, Boltz-Nitulescu G and Roth E (1997). “Low glutamine concentrations induce phenotypical and functional differentiation of U937 myelomonocytic cells”. J. Nutr. 127 (11): 2151–2157. PMID 9349841.
- ^ Matsuno, T (1991). “Pathway of glutamate oxidation and its regulation in HuH13 line of human hepatoma cells”. J. Cell. Physiol. 148 (2): 290–294. doi:10.1002/jcp.1041480215. PMID 1679060.
- ^ Parlo, RA; Coleman PS (1984). “Enhanced rate of citrate export from cholesterol-rich hepatoma mitochondria. The truncated Krebs cycle and other metabolic ramifications of mitochondrial membrane cholesterol”. J. Biol. Chem. 259 (16): 9997–10003. PMID 6469976.
- ^ Mazurek, S; Grimm H, Boschek CB, Vaupel P and Eigenbrodt E (2002). “Pyruvate kinase type M2: a crossroad in the tumor metabolome”. Brit. J. Nutr. 87: S23–S29. doi:10.1079/BJN2001455. PMID 11895152.
- ^ Eck, HP; Drings P and Dröge W (1989). “Plasma glutamate levels, lymphocyte reactivity and death in patients with bronchial carcinoma”. J. Cancer Res. Clin. Oncol. 115 (6): 571–574. doi:10.1007/BF00391360. PMID 2558118.
- ^ Grimm, H; Tibell A, Norrlind B, Blecher C, Wilker S, and Schwemmle K (1994). “Immunoregulation by parental lipids: impact of the n-3 to n-6 fatty acid ratio”. J. Parenter. Enteral. Nutr. 18 (5): 417–421. doi:10.1177/0148607194018005417. PMID 7815672.
- ^ Jiang, WG; Bryce RP and Hoorobin DF (1998). “Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications”. Crit. Rev. Oncol. Hematol. 27 (3): 179–209. doi:10.1016/S1040-8428(98)00003-1. PMID 9649932.
[続きの解説]
「グルタミノリシス」の続きの解説一覧
- 1 グルタミノリシスとは
- 2 グルタミノリシスの概要
- 3 腫瘍細胞における重要なエネルギー源として
- 4 関連項目
- グルタミノリシスのページへのリンク
