ミューズ細胞
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/03/10 15:17 UTC 版)
ミューズ細胞（ミューズさいぼう、英: Muse cell; Multi-lineage differentiating Stress Enduring cell）は生体に内在する非腫瘍性の多能性幹細胞であり、臍帯を含めたほぼすべての臓器の結合組織、骨髄、末梢血に存在している[1][2][3][4][5][6][7]。ヒト線維芽細胞やヒト骨髄間葉系細胞、脂肪由来幹細胞などの市販の間葉系細胞に1〜数％の割合で含まれており、自発的に、またはサイトカインの誘導により1細胞から体を構成する要素である外胚葉系、中胚葉系、内胚葉系の細胞に分化することができる[8][9][10]。さらに、この３胚葉性の分化能は自己複製可能である。多能性幹細胞の関連遺伝子の発現を認めるが、腫瘍性に関連する遺伝子は体細胞レベルと同等で低く、テロメラーゼ活性も低く抑えられているため、無限増殖を行わない。従ってミューズ細胞は生体に移植されても腫瘍形成の危険が極めて低い。ミューズ細胞は2010年に東北大学の出澤真理教授のグループによってはじめて発見・報告された[1]。2018年1月から急性心筋梗塞、脳梗塞、表皮水疱症、脊髄損傷、筋委縮性側索硬化症、新型コロナウイルス（SARS-CoV-2）感染症に伴う 急性呼吸窮迫症候群（ARDS）を対象とした探索的臨床試験を行った[11][12][13][14][15]。また新生児低酸素性虚血性脳症に対する医師主導治験が開始されている。[16] 脳梗塞患者を対象としたプラセボ対照二重盲検比較試験の 臨床試験結果が報告されている[17][18] 。また、心筋梗塞[19]と表皮水疱症[20]、および筋萎縮性側索硬化症[21]についても論文が報告されている。
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab Kuroda, Yasumasa; Kitada, Masaaki; Wakao, Shohei; Nishikawa, Kouki; Tanimura, Yukihiro; Makinoshima, Hideki; Goda, Makoto; Akashi, Hideo et al. (2010-05-11). “Unique multipotent cells in adult human mesenchymal cell populations”. Proceedings of the National Academy of Sciences of the United States of America 107 (19): 8639–8643. doi:10.1073/pnas.0911647107. ISSN 1091-6490. PMC 2889306. PMID 20421459.
- ^ a b Dezawa, Mari, ed (2018). Muse Cells: Endogenous Reparative Pluripotent Stem Cells. 1103. Tokyo: Springer Japan. doi:10.1007/978-4-431-56847-6. ISBN 9784431568452
- ^ a b c d e f g h i j k l m n o Wakao, Shohei; Kitada, Masaaki; Kuroda, Yasumasa; Shigemoto, Taeko; Matsuse, Dai; Akashi, Hideo; Tanimura, Yukihiro; Tsuchiyama, Kenichiro et al. (2011-06-14). “Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts”. Proceedings of the National Academy of Sciences of the United States of America 108 (24): 9875–9880. doi:10.1073/pnas.1100816108. ISSN 1091-6490. PMC 3116385. PMID 21628574.
- ^ a b c d Dezawa, Mari (2016). “Muse Cells Provide the Pluripotency of Mesenchymal Stem Cells: Direct Contribution of Muse Cells to Tissue Regeneration”. Cell Transplantation 25 (5): 849–861. doi:10.3727/096368916X690881. ISSN 1555-3892. PMID 26884346.
- ^ a b c d e Hori, Emiko; Hayakawa, Yumiko; Hayashi, Tomohide; Hori, Satoshi; Okamoto, Soushi; Shibata, Takashi; Kubo, Michiya; Horie, Yukio et al. (2016-6). “Mobilization of Pluripotent Multilineage-Differentiating Stress-Enduring Cells in Ischemic Stroke”. Journal of Stroke and Cerebrovascular Diseases: The Official Journal of National Stroke Association 25 (6): 1473–1481. doi:10.1016/j.jstrokecerebrovasdis.2015.12.033. ISSN 1532-8511. PMID 27019988.
- ^ a b Leng, Zikuan; Sun, Dongming; Huang, Zihao; Tadmori, Iman; Chiang, Ning; Kethidi, Nikhit; Sabra, Ahmed; Kushida, Yoshihiro et al. (2019-07). “Quantitative Analysis of SSEA3+ Cells from Human Umbilical Cord after Magnetic Sorting”. Cell Transplantation 28 (7): 907–923. doi:10.1177/0963689719844260. ISSN 1555-3892. PMC 6719495. PMID 30997834.
- ^ Sato, Tetsuya; Wakao, Shohei; Kushida, Yoshihiro; Tatsumi, Kazuki; Kitada, Masaaki; Abe, Takatsugu; Niizuma, Kuniyasu; Tominaga, Teiji et al. (2020-01). “A Novel Type of Stem Cells Double-Positive for SSEA-3 and CD45 in Human Peripheral Blood”. Cell Transplantation 29: 963689720923574. doi:10.1177/0963689720923574. ISSN 1555-3892. PMC 7586270. PMID 32525407.
- ^ a b Kuroda, Yasumasa; Wakao, Shohei; Kitada, Masaaki; Murakami, Toru; Nojima, Makoto; Dezawa, Mari (2013). “Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells”. Nature Protocols 8 (7): 1391–1415. doi:10.1038/nprot.2013.076. ISSN 1750-2799. PMID 23787896.
- ^ a b c d e f g Ogura, Fumitaka; Wakao, Shohei; Kuroda, Yasumasa; Tsuchiyama, Kenichiro; Bagheri, Mozhdeh; Heneidi, Saleh; Chazenbalk, Gregorio; Aiba, Setsuya et al. (2014-04-01). “Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine”. Stem Cells and Development 23 (7): 717–728. doi:10.1089/scd.2013.0473. ISSN 1557-8534. PMID 24256547.
- ^ a b c d e f g Heneidi, Saleh; Simerman, Ariel A.; Keller, Erica; Singh, Prapti; Li, Xinmin; Dumesic, Daniel A.; Chazenbalk, Gregorio (2013). “Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue”. PloS One 8 (6): e64752. doi:10.1371/journal.pone.0064752. ISSN 1932-6203. PMC 3673968. PMID 23755141.
- ^ a b c “急性心筋梗塞を対象疾患としたMuse細胞製品の探索的臨床試験開始について”. 2018年8月20日閲覧。
- ^ a b c “脳梗塞患者を対象としたMuse細胞製品の探索的臨床試験の開始について”. 2019年2月20日閲覧。
- ^ a b c “表皮水疱症を対象疾患としたMuse細胞製品の探索的臨床試験開始について”. 2019年2月20日閲覧。
- ^ a b c “脊髄（せきずい）損傷を対象疾患とした Muse 細胞製品の臨床試験開始について”. 生命科学インスティテュート. 2019年７月９日閲覧。
- ^ a b c “トップページ | 生命科学インスティテュート（LSII）”. www.lsii.co.jp. 2021年6月10日閲覧。
- ^ a b c “Muse細胞製品を用いた新生児低酸素性虚血性脳症に対する 医師主導治験開始に関するお知らせについて - プレスリリース - 病院からのお知らせ | 名古屋大学医学部附属病院”. www.med.nagoya-u.ac.jp. 2021年6月10日閲覧。
- ^ a b “[https://www.lsii.co.jp/assets/pdf/20210518-1.pdf 脳梗塞患者を対象とした Muse 細胞製品「CL2020」の 臨床試験結果に関する発表について]”. LSII. 2021年6月10日閲覧。
- ^ a b c d Niizuma, Kuniyasu; Osawa, Shin-Ichiro; Endo, Hidenori; Izumi, Shin-Ichi; Ataka, Kota; Hirakawa, Akihiro; Iwano, Masao; Tominaga, Teiji (2023-12). “Randomized placebo-controlled trial of CL2020, an allogenic muse cell-based product, in subacute ischemic stroke”. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 43 (12): 2029–2039. doi:10.1177/0271678X231202594. ISSN 1559-7016. PMID 37756573.
- ^ a b Noda, Toshiyuki; Nishigaki, Kazuhiko; Minatoguchi, Shinya (2020-06-25). “Safety and Efficacy of Human Muse Cell-Based Product for Acute Myocardial Infarction in a First-in-Human Trial”. Circulation Journal: Official Journal of the Japanese Circulation Society 84 (7): 1189–1192. doi:10.1253/circj.CJ-20-0307. ISSN 1347-4820. PMID 32522904.
- ^ a b Fujita, Y.; Nohara, T.; Takashima, S.; Natsuga, K.; Adachi, M.; Yoshida, K.; Shinkuma, S.; Takeichi, T. et al. (2021-03-03). “Intravenous allogeneic multilineage-differentiating stress-enduring cells in adults with dystrophic epidermolysis bullosa: a phase 1/2 open-label study”. Journal of the European Academy of Dermatology and Venereology: JEADV. doi:10.1111/jdv.17201. ISSN 1468-3083. PMID 33656198.
- ^ a b c d Yamashita, Toru; Nakano, Yumiko; Sasaki, Ryo; Tadokoro, Koh; Omote, Yoshio; Yunoki, Taijun; Kawahara, Yuko; Matsumoto, Namiko et al. (2023). “Safety and Clinical Effects of a Muse Cell-Based Product in Patients With Amyotrophic Lateral Sclerosis: Results of a Phase 2 Clinical Trial”. Cell Transplantation 32: 9636897231214370. doi:10.1177/09636897231214370. ISSN 1555-3892. PMID 38014622.
- ^ Alessio, Nicola; Özcan, Servet; Tatsumi, Kazuki; Murat, Ayşegül; Peluso, Gianfranco; Dezawa, Mari; Galderisi, Umberto (2017-01-02). “The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation”. Cell Cycle (Georgetown, Tex.) 16 (1): 33–44. doi:10.1080/15384101.2016.1211215. ISSN 1551-4005. PMC 5270533. PMID 27463232.
- ^ Alessio, Nicola; Squillaro, Tiziana; Özcan, Servet; Di Bernardo, Giovanni; Venditti, Massimo; Melone, Mariarosa; Peluso, Gianfranco; Galderisi, Umberto (2018-04-10). “Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells”. Oncotarget 9 (27): 19328–19341. doi:10.18632/oncotarget.25039. ISSN 1949-2553. PMC 5922400. PMID 29721206.
- ^ a b c d e Gimeno, María L.; Fuertes, Florencia; Barcala Tabarrozzi, Andres E.; Attorressi, Alejandra I.; Cucchiani, Rodolfo; Corrales, Luis; Oliveira, Talita C.; Sogayar, Mari C. et al. (2017-1). “Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1”. Stem Cells Translational Medicine 6 (1): 161–173. doi:10.5966/sctm.2016-0014. ISSN 2157-6564. PMC 5442729. PMID 28170177.
- ^ a b c d e f g h Katagiri, H.; Kushida, Y.; Nojima, M.; Kuroda, Y.; Wakao, S.; Ishida, K.; Endo, F.; Kume, K. et al. (2016-2). “A Distinct Subpopulation of Bone Marrow Mesenchymal Stem Cells, Muse Cells, Directly Commit to the Replacement of Liver Components”. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16 (2): 468–483. doi:10.1111/ajt.13537. ISSN 1600-6143. PMID 26663569.
- ^ a b c d e f Uchida, Hiroki; Morita, Takahiro; Niizuma, Kuniyasu; Kushida, Yoshihiro; Kuroda, Yasumasa; Wakao, Shohei; Sakata, Hiroyuki; Matsuzaka, Yoshiya et al. (2016-1). “Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation”. Stem Cells (Dayton, Ohio) 34 (1): 160–173. doi:10.1002/stem.2206. ISSN 1549-4918. PMID 26388204.
- ^ a b c d e Kinoshita, Kahori; Kuno, Shinichiro; Ishimine, Hisako; Aoi, Noriyuki; Mineda, Kazuhide; Kato, Harunosuke; Doi, Kentaro; Kanayama, Koji et al. (2015-2). “Therapeutic Potential of Adipose-Derived SSEA-3-Positive Muse Cells for Treating Diabetic Skin Ulcers”. Stem Cells Translational Medicine 4 (2): 146–155. doi:10.5966/sctm.2014-0181. ISSN 2157-6564. PMC 4303359. PMID 25561682.
- ^ a b c d Yamada, Yoshihisa; Wakao, Shohei; Kushida, Yoshihiro; Minatoguchi, Shingo; Mikami, Atsushi; Higashi, Kenshi; Baba, Shinya; Shigemoto, Taeko et al. (2018-04-13). “S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction”. Circulation Research 122 (8): 1069–1083. doi:10.1161/CIRCRESAHA.117.311648. ISSN 1524-4571. PMID 29475983.
- ^ “トップページ | 生命科学インスティテュート（LSII）”. www.lsii.co.jp. 2021年6月10日閲覧。
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- ^ a b Wakao, Shohei; Kitada, Masaaki; Dezawa, Mari (2013-1). “The elite and stochastic model for iPS cell generation: multilineage-differentiating stress enduring (Muse) cells are readily reprogrammable into iPS cells”. Cytometry. Part A: The Journal of the International Society for Analytical Cytology 83 (1): 18–26. doi:10.1002/cyto.a.22069. ISSN 1552-4930. PMID 22693162.
- ^ a b Tsuchiyama, Kenichiro; Wakao, Shohei; Kuroda, Yasumasa; Ogura, Fumitaka; Nojima, Makoto; Sawaya, Natsue; Yamasaki, Kenshi; Aiba, Setsuya et al. (2013-10). “Functional melanocytes are readily reprogrammable from multilineage-differentiating stress-enduring (muse) cells, distinct stem cells in human fibroblasts”. The Journal of Investigative Dermatology 133 (10): 2425–2435. doi:10.1038/jid.2013.172. ISSN 1523-1747. PMID 23563197.
- ^ a b c d e f Uchida, Nao; Kushida, Yoshihiro; Kitada, Masaaki; Wakao, Shohei; Kumagai, Naonori; Kuroda, Yasumasa; Kondo, Yoshiaki; Hirohara, Yukari et al. (2017-10). “Beneficial Effects of Systemically Administered Human Muse Cells in Adriamycin Nephropathy”. Journal of the American Society of Nephrology: JASN 28 (10): 2946–2960. doi:10.1681/ASN.2016070775. ISSN 1533-3450. PMC 5619953. PMID 28674043.
- ^ a b Amin, Mohamed; Kushida, Yoshihiro; Wakao, Shohei; Kitada, Masaaki; Tatsumi, Kazuki; Dezawa, Mari (2018-2). “Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype”. Cell Transplantation 27 (2): 285–298. doi:10.1177/0963689717721514. ISSN 1555-3892. PMC 5898685. PMID 29637816.
- ^ a b c d e f g Iseki, Masahiro; Kushida, Yoshihiro; Wakao, Shohei; Akimoto, Takahiro; Mizuma, Masamichi; Motoi, Fuyuhiko; Asada, Ryuta; Shimizu, Shinobu et al. (05 09, 2017). “Muse Cells, Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis”. Cell Transplantation 26 (5): 821–840. doi:10.3727/096368916X693662. ISSN 1555-3892. PMC 5657714. PMID 27938474.
- ^ a b c d Wakao, Shohei; Oguma, Yo; Kushida, Yoshihiro; Kuroda, Yasumasa; Tatsumi, Kazuki; Dezawa, Mari (2022-10-06). “Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame” (英語). Cellular and Molecular Life Sciences 79 (11): 542. doi:10.1007/s00018-022-04555-0. ISSN 1420-9071. PMC PMC9537123. PMID 36203068.
- ^ a b c d Yamada, Yoshihisa; Wakao, Shohei; Kushida, Yoshihiro; Minatoguchi, Shingo; Mikami, Atsushi; Higashi, Kenshi; Baba, Shinya; Shigemoto, Taeko et al. (2018-04-13). “S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction”. Circulation Research 122 (8): 1069–1083. doi:10.1161/CIRCRESAHA.117.311648. ISSN 1524-4571. PMID 29475983.
- ^ a b c d Uchida, Hiroki; Niizuma, Kuniyasu; Kushida, Yoshihiro; Wakao, Shohei; Tominaga, Teiji; Borlongan, Cesario V.; Dezawa, Mari (02 2017). “Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model”. Stroke 48 (2): 428–435. doi:10.1161/STROKEAHA.116.014950. ISSN 1524-4628. PMC 5262965. PMID 27999136.
- ^ a b Yamauchi, Tomohiro; Kuroda, Yasumasa; Morita, Takahiro; Shichinohe, Hideo; Houkin, Kiyohiro; Dezawa, Mari; Kuroda, Satoshi (2015). “Therapeutic effects of human multilineage-differentiating stress enduring (MUSE) cell transplantation into infarct brain of mice”. PloS One 10 (3): e0116009. doi:10.1371/journal.pone.0116009. ISSN 1932-6203. PMC 4351985. PMID 25747577.
- ^ a b c Shimamura, Norihito; Kakuta, Kiyohide; Wang, Liang; Naraoka, Masato; Uchida, Hiroki; Wakao, Shohei; Dezawa, Mari; Ohkuma, Hiroki (02 2017). “Neuro-regeneration therapy using human Muse cells is highly effective in a mouse intracerebral hemorrhage model”. Experimental Brain Research 235 (2): 565–572. doi:10.1007/s00221-016-4818-y. ISSN 1432-1106. PMID 27817105.
- ^ a b c Hosoyama, Katsuhiro; Wakao, Shohei; Kushida, Yoshihiro; Ogura, Fumitaka; Maeda, Kay; Adachi, Osamu; Kawamoto, Shunsuke; Dezawa, Mari et al. (2018-6). “Intravenously injected human multilineage-differentiating stress-enduring cells selectively engraft into mouse aortic aneurysms and attenuate dilatation by differentiating into multiple cell types”. The Journal of Thoracic and Cardiovascular Surgery 155 (6): 2301–2313.e4. doi:10.1016/j.jtcvs.2018.01.098. ISSN 1097-685X. PMID 29559260.
- ^ a b c Fujita, Yasuyuki; Komatsu, Miho; Lee, San Eun; Kushida, Yoshihiro; Nakayama-Nishimura, Chihiro; Matsumura, Wakana; Takashima, Shota; Shinkuma, Satoru et al. (2021-01). “Intravenous Injection of Muse Cells as a Potential Therapeutic Approach for Epidermolysis Bullosa”. The Journal of Investigative Dermatology 141 (1): 198–202.e6. doi:10.1016/j.jid.2020.05.092. ISSN 1523-1747. PMID 32540249.
- ^ a b c Yamashita, Toru; Kushida, Yoshihiro; Wakao, Shohei; Tadokoro, Koh; Nomura, Emi; Omote, Yoshio; Takemoto, Mami; Hishikawa, Nozomi et al. (2020-10-13). “Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis”. Scientific Reports 10 (1): 17102. doi:10.1038/s41598-020-74216-4. ISSN 2045-2322. PMC 7554047. PMID 33051552.
- ^ a b c Suzuki, Toshihiko; Sato, Yoshiaki; Kushida, Yoshihiro; Tsuji, Masahiro; Wakao, Shohei; Ueda, Kazuto; Imai, Kenji; Iitani, Yukako et al. (2020-11-22). “Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy” (英語). Journal of Cerebral Blood Flow & Metabolism: 0271678X20972656. doi:10.1177/0271678X20972656. ISSN 0271-678X.
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[続きの解説]
「ミューズ細胞」の続きの解説一覧
- ミューズ細胞のページへのリンク
