SGK1とは？ わかりやすく解説

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SGK1

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/08/19 16:06 UTC 版)

SGK1（serum and glucocorticoid-regulated kinase 1）は、ヒトではSGK1遺伝子によってコードされる酵素（セリン/スレオニンキナーゼ）である。


出典
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118515 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019970 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ a b c d e f g h i j k Lang, Florian; Strutz-Seebohm, Nathalie; Seebohm, Guiscard; Lang, Undine E. (2010-09-15). “Significance of SGK1 in the regulation of neuronal function”. The Journal of Physiology 588 (Pt 18): 3349–3354. doi:10.1113/jphysiol.2010.190926. ISSN 1469-7793. PMC 2988501. PMID 20530112. https://pubmed.ncbi.nlm.nih.gov/20530112. 
  6. ^ a b c d e f g h i Lang, Florian; Shumilina, Ekaterina (2013-01). “Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1”. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 27 (1): 3–12. doi:10.1096/fj.12-218230. ISSN 1530-6860. PMID 23012321. https://pubmed.ncbi.nlm.nih.gov/23012321. 
  7. ^ a b c d Schoenebeck, Bodo; Bader, Verian; Zhu, Xin Ran; Schmitz, Beate; Lübbert, Hermann; Stichel, Christine C. (2005-10). “Sgk1, a cell survival response in neurodegenerative diseases”. Molecular and Cellular Neurosciences 30 (2): 249–264. doi:10.1016/j.mcn.2005.07.017. ISSN 1044-7431. PMID 16125969. https://pubmed.ncbi.nlm.nih.gov/16125969. 
  8. ^ Loffing, J.; Zecevic, M.; Féraille, E.; Kaissling, B.; Asher, C.; Rossier, B. C.; Firestone, G. L.; Pearce, D. et al. (2001-04). “Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK”. American Journal of Physiology. Renal Physiology 280 (4): F675–682. doi:10.1152/ajprenal.2001.280.4.F675. ISSN 1931-857X. PMID 11249859. https://pubmed.ncbi.nlm.nih.gov/11249859. 
  9. ^ Kuntzsch, Dana; Bergann, Theresa; Dames, Petra; Fromm, Anja; Fromm, Michael; Davis, Rohan A.; Melzig, Matthias F.; Schulzke, Joerg D. (2012). “The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs”. PloS One 7 (11): e49426. doi:10.1371/journal.pone.0049426. ISSN 1932-6203. PMC 3496671. PMID 23152905. https://pubmed.ncbi.nlm.nih.gov/23152905. 
  10. ^ Wald, H.; Garty, H.; Palmer, L. G.; Popovtzer, M. M. (08 1998). “Differential regulation of ROMK expression in kidney cortex and medulla by aldosterone and potassium”. The American Journal of Physiology 275 (2): F239–245. doi:10.1152/ajprenal.1998.275.2.F239. ISSN 0002-9513. PMID 9691014. https://pubmed.ncbi.nlm.nih.gov/9691014. 
  11. ^ Palmada, Monica; Poppendieck, Susanne; Embark, Hamdy M.; van de Graaf, Stan F. J.; Boehmer, Christoph; Bindels, René J. M.; Lang, Florian (2005). “Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1”. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 15 (1-4): 175–182. doi:10.1159/000083650. ISSN 1015-8987. PMID 15665527. https://pubmed.ncbi.nlm.nih.gov/15665527. 
  12. ^ Jing, Haiyan; Na, Tao; Zhang, Wei; Wu, Guojin; Liu, Chuanyong; Peng, Ji-Bin (2011-01-28). “Concerted actions of NHERF2 and WNK4 in regulating TRPV5”. Biochemical and Biophysical Research Communications 404 (4): 979–984. doi:10.1016/j.bbrc.2010.12.095. ISSN 1090-2104. PMC 3031669. PMID 21187068. https://pubmed.ncbi.nlm.nih.gov/21187068. 
  13. ^ a b c Palmada, Monica; Dieter, Michael; Boehmer, Christoph; Waldegger, Siegfried; Lang, Florian (2004-09-03). “Serum and glucocorticoid inducible kinases functionally regulate ClC-2 channels”. Biochemical and Biophysical Research Communications 321 (4): 1001–1006. doi:10.1016/j.bbrc.2004.07.064. ISSN 0006-291X. PMID 15358127. https://pubmed.ncbi.nlm.nih.gov/15358127. 
  14. ^ Boehmer, Christoph; Wilhelm, Viktoria; Palmada, Monica; Wallisch, Sabine; Henke, Guido; Brinkmeier, Heinrich; Cohen, Philip; Pieske, Burkert et al. (2003-03-15). “Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A”. Cardiovascular Research 57 (4): 1079–1084. doi:10.1016/s0008-6363(02)00837-4. ISSN 0008-6363. PMID 12650886. https://pubmed.ncbi.nlm.nih.gov/12650886. 
  15. ^ a b c d e f Lang, Florian; Stournaras, Christos (2013-04). “Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth”. Hormones (Athens, Greece) 12 (2): 160–171. doi:10.14310/horm.2002.1401. ISSN 2520-8721. PMID 23933686. https://pubmed.ncbi.nlm.nih.gov/23933686. 
  16. ^ Takumi, T.; Ohkubo, H.; Nakanishi, S. (1988-11-18). “Cloning of a membrane protein that induces a slow voltage-gated potassium current”. Science (New York, N.Y.) 242 (4881): 1042–1045. doi:10.1126/science.3194754. ISSN 0036-8075. PMID 3194754. https://pubmed.ncbi.nlm.nih.gov/3194754. 
  17. ^ a b c Gamper, N.; Fillon, S.; Huber, S. M.; Feng, Y.; Kobayashi, T.; Cohen, P.; Lang, F. (2002-02). “IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1”. Pflugers Archiv: European Journal of Physiology 443 (4): 625–634. doi:10.1007/s00424-001-0741-5. ISSN 0031-6768. PMID 11907830. https://pubmed.ncbi.nlm.nih.gov/11907830. 
  18. ^ a b c Strutz-Seebohm, Nathalie; Seebohm, Guiscard; Shumilina, Ekaterina; Mack, Andreas F.; Wagner, Hans-Joachim; Lampert, Angelika; Grahammer, Florian; Henke, Guido et al. (2005-06-01). “Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression”. The Journal of Physiology 565 (Pt 2): 391–401. doi:10.1113/jphysiol.2004.079624. ISSN 0022-3751. PMC 1464533. PMID 15774535. https://pubmed.ncbi.nlm.nih.gov/15774535. 
  19. ^ a b Boini, Krishna M.; Hennige, Anita M.; Huang, Dan Yang; Friedrich, Björn; Palmada, Monica; Boehmer, Christoph; Grahammer, Florian; Artunc, Ferruh et al. (2006-07). “Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance”. Diabetes 55 (7): 2059–2066. doi:10.2337/db05-1038. ISSN 0012-1797. PMID 16804076. https://pubmed.ncbi.nlm.nih.gov/16804076. 
  20. ^ a b Shojaiefard, Manzar; Christie, David L.; Lang, Florian (2005-09-02). “Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3”. Biochemical and Biophysical Research Communications 334 (3): 742–746. doi:10.1016/j.bbrc.2005.06.164. ISSN 0006-291X. PMID 16036218. https://pubmed.ncbi.nlm.nih.gov/16036218. 
  21. ^ a b c d e f g h i j k l m n o p q r Lang, Florian; Böhmer, Christoph; Palmada, Monica; Seebohm, Guiscard; Strutz-Seebohm, Nathalie; Vallon, Volker (2006-10). “(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms”. Physiological Reviews 86 (4): 1151–1178. doi:10.1152/physrev.00050.2005. ISSN 0031-9333. PMID 17015487. https://pubmed.ncbi.nlm.nih.gov/17015487. 
  22. ^ Wulff, Peer; Vallon, Volker; Huang, Dan Yang; Völkl, Harald; Yu, Fang; Richter, Kerstin; Jansen, Martina; Schlünz, Michaela et al. (2002-11). “Impaired renal Na(+) retention in the sgk1-knockout mouse”. The Journal of Clinical Investigation 110 (9): 1263–1268. doi:10.1172/JCI15696. ISSN 0021-9738. PMC 151609. PMID 12417564. https://pubmed.ncbi.nlm.nih.gov/12417564. 
  23. ^ a b c Ma, Yun L.; Tsai, Ming C.; Hsu, Wei L.; Lee, Eminy H. Y. (2006-03). “SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons”. Learning & Memory (Cold Spring Harbor, N.Y.) 13 (2): 114–118. doi:10.1101/lm.179206. ISSN 1072-0502. PMID 16585788. https://pubmed.ncbi.nlm.nih.gov/16585788. 
  24. ^ Waldegger, S.; Barth, P.; Raber, G.; Lang, F. (1997-04-29). “Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume”. Proceedings of the National Academy of Sciences of the United States of America 94 (9): 4440–4445. doi:10.1073/pnas.94.9.4440. ISSN 0027-8424. PMC 20741. PMID 9114008. https://pubmed.ncbi.nlm.nih.gov/9114008. 
  25. ^ a b Anacker, Christoph; Cattaneo, Annamaria; Musaelyan, Ksenia; Zunszain, Patricia A.; Horowitz, Mark; Molteni, Raffaella; Luoni, Alessia; Calabrese, Francesca et al. (2013-05-21). “Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis”. Proceedings of the National Academy of Sciences of the United States of America 110 (21): 8708–8713. doi:10.1073/pnas.1300886110. ISSN 1091-6490. PMC 3666742. PMID 23650397. https://pubmed.ncbi.nlm.nih.gov/23650397. 
  26. ^ Leong, Meredith L. L.; Maiyar, Anita C.; Kim, Brian; O'Keeffe, Bridget A.; Firestone, Gary L. (2003-02-21). “Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells”. The Journal of Biological Chemistry 278 (8): 5871–5882. doi:10.1074/jbc.M211649200. ISSN 0021-9258. PMID 12488318. https://pubmed.ncbi.nlm.nih.gov/12488318. 
  27. ^ Wald, H.; Garty, H.; Palmer, L. G.; Popovtzer, M. M. (1998-08). “Differential regulation of ROMK expression in kidney cortex and medulla by aldosterone and potassium”. The American Journal of Physiology 275 (2): F239–245. doi:10.1152/ajprenal.1998.275.2.F239. ISSN 0002-9513. PMID 9691014. https://pubmed.ncbi.nlm.nih.gov/9691014. 
  28. ^ Faresse, Nourdine; Lagnaz, Dagmara; Debonneville, Anne; Ismailji, Adil; Maillard, Marc; Fejes-Toth, Geza; Náray-Fejes-Tóth, Aniko; Staub, Olivier (2012-04-15). “Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype”. American Journal of Physiology. Renal Physiology 302 (8): F977–985. doi:10.1152/ajprenal.00535.2011. ISSN 1522-1466. PMID 22301619. https://pubmed.ncbi.nlm.nih.gov/22301619. 
  29. ^ Huang, Dan Yang; Boini, Krishna M.; Friedrich, Björn; Metzger, Marco; Just, Lothar; Osswald, Hartmut; Wulff, Peer; Kuhl, Dietmar et al. (2006-04). “Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1”. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 290 (4): R935–944. doi:10.1152/ajpregu.00382.2005. ISSN 0363-6119. PMID 16284089. https://pubmed.ncbi.nlm.nih.gov/16284089. 
  30. ^ Coric, Tatjana; Hernandez, Nelmary; Alvarez de la Rosa, Diego; Shao, Deren; Wang, Tong; Canessa, Cecilia M. (2004-04). “Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium”. American Journal of Physiology. Gastrointestinal and Liver Physiology 286 (4): G663–670. doi:10.1152/ajpgi.00364.2003. ISSN 0193-1857. PMID 14630642. https://pubmed.ncbi.nlm.nih.gov/14630642. 
  31. ^ Das, Saumya; Aiba, Takeshi; Rosenberg, Michael; Hessler, Katherine; Xiao, Chunyang; Quintero, Pablo A.; Ottaviano, Filomena G.; Knight, Ashley C. et al. (2012-10-30). “Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling”. Circulation 126 (18): 2208–2219. doi:10.1161/CIRCULATIONAHA.112.115592. ISSN 1524-4539. PMC 3484211. PMID 23019294. https://pubmed.ncbi.nlm.nih.gov/23019294. 
  32. ^ Busjahn, Andreas; Seebohm, Guiscard; Maier, Gottlieb; Toliat, Mohammad Reza; Nürnberg, Peter; Aydin, Atakan; Luft, Friedrich C.; Lang, Florian (2004). “Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval”. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 14 (3): 135–142. doi:10.1159/000078105. ISSN 1015-8987. PMID 15107590. https://pubmed.ncbi.nlm.nih.gov/15107590. 
  33. ^ a b “Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels”. Circulation Research 100 (5): 686–692. (Mar 2007). doi:10.1161/01.RES.0000260250.83824.8f. PMID 17293474. 
  34. ^ “Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels”. Circulation Research 103 (12): 1451–1457. (Dec 2008). doi:10.1161/CIRCRESAHA.108.177360. PMID 19008479. 
  35. ^ Pellegrini-Giampietro, D. E.; Bennett, M. V.; Zukin, R. S. (1992-09-14). “Are Ca(2+)-permeable kainate/AMPA receptors more abundant in immature brain?”. Neuroscience Letters 144 (1-2): 65–69. doi:10.1016/0304-3940(92)90717-l. ISSN 0304-3940. PMID 1331916. https://pubmed.ncbi.nlm.nih.gov/1331916. 
  36. ^ Rangone, Hélène; Poizat, Ghislaine; Troncoso, Juan; Ross, Christopher A.; MacDonald, Marcy E.; Saudou, Frédéric; Humbert, Sandrine (2004-01). “The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin”. The European Journal of Neuroscience 19 (2): 273–279. doi:10.1111/j.0953-816x.2003.03131.x. ISSN 0953-816X. PMID 14725621. https://pubmed.ncbi.nlm.nih.gov/14725621. 
  37. ^ Roux, Jean-Christophe; Zala, Diana; Panayotis, Nicolas; Borges-Correia, Ana; Saudou, Frédéric; Villard, Laurent (2012-02). “Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway”. Neurobiology of Disease 45 (2): 786–795. doi:10.1016/j.nbd.2011.11.002. ISSN 1095-953X. PMID 22127389. https://pubmed.ncbi.nlm.nih.gov/22127389. 
  38. ^ Nuber, Ulrike A.; Kriaucionis, Skirmantas; Roloff, Tim C.; Guy, Jacky; Selfridge, Jim; Steinhoff, Christine; Schulz, Ralph; Lipkowitz, Bettina et al. (2005-08-01). “Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome”. Human Molecular Genetics 14 (15): 2247–2256. doi:10.1093/hmg/ddi229. ISSN 0964-6906. PMID 16002417. https://pubmed.ncbi.nlm.nih.gov/16002417. 
  39. ^ “Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain”. Molecular Biology of the Cell 14 (3): 1221–39. (Mar 2003). doi:10.1091/mbc.E02-03-0170. PMC 151592. PMID 12631736. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151592/. 
  40. ^ “BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase”. The Journal of Biological Chemistry 276 (12): 8631–4. (Mar 2001). doi:10.1074/jbc.C000838200. PMID 11254654. 
  41. ^ “Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance”. Biochimica et Biophysica Acta (BBA) - Biomembranes 1612 (1): 59–64. (May 2003). doi:10.1016/s0005-2736(03)00083-x. PMID 12729930. 
  42. ^ “Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel”. The Journal of Biological Chemistry 277 (1): 5–8. (Jan 2002). doi:10.1074/jbc.C100623200. PMID 11696533. 
  43. ^ a b “The Na(+)/H(+) exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1”. Biochemical and Biophysical Research Communications 298 (2): 207–15. (Oct 2002). doi:10.1016/s0006-291x(02)02428-2. PMID 12387817. 
  44. ^ “Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway”. The EMBO Journal 18 (11): 3024–33. (Jun 1999). doi:10.1093/emboj/18.11.3024. PMC 1171384. PMID 10357815. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171384/. 
  45. ^ “Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2”. The Journal of Biological Chemistry 277 (10): 7676–83. (Mar 2002). doi:10.1074/jbc.M107768200. PMID 11751930. 

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SGK1のお隣キーワード

SGB

SGD

SGF

SGG

SGI

SGI Onyx

SGK1

SGL

SGLT2阻害薬

SGLカーボン

SGM

SGML実体

SGN

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