NEDD4L
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2020/04/23 15:51 UTC 版)
NEDD4L（Neural precursor cell expressed developmentally downregulated gene 4-like）またはNEDD4-2は、NEDD4ファミリーに属する酵素（ユビキチンリガーゼ）である。ヒトではNEDD4L遺伝子にコードされる[5][6][7][8]。マウスでは、NEDD4-2、Nedd4-2遺伝子として一般的に知られている。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000049759 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024589 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae”. Mol. Cell. Biol. 20 (1): 224–32. (Jan 2000). doi:10.1128/MCB.20.1.224-232.2000. PMC: 85078. PMID 10594025.
- ^ a b “The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel”. J. Biol. Chem. 276 (11): 8597–601. (May 2001). doi:10.1074/jbc.C000906200. PMID 11244092.
- ^ “Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel”. Am. J. Physiol. Renal Physiol. 294 (5): F1157-65. (May 2008). doi:10.1152/ajprenal.00339.2007. PMC: 2424110. PMID 18322022.
- ^ “Entrez Gene: NEDD4L Neural precursor cell expressed, developmentally down-regulated 4-like”. 2019年11月14日閲覧。
- ^ “Role of the UPS in Liddle syndrome”. BMC Biochem. 9 Suppl 1: S5. (2008). doi:10.1186/1471-2091-9-S1-S5. PMC: 2582799. PMID 19007435.
- ^ a b c “Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions”. Trends Cell Biol. 9 (5): 166–9. (May 1999). doi:10.1016/s0962-8924(99)01541-x. PMID 10322449.
- ^ a b c d e “Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects”. Biochim. Biophys. Acta 1843 (1): 61–74. (Jan 2014). doi:10.1016/j.bbamcr.2013.03.024. PMID 23545411.
- ^ a b c d e “Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions”. Cell Death Differ. 17 (1): 68–77. (Jan 2010). doi:10.1038/cdd.2009.84. PMC: 2818775. PMID 19557014.
- ^ a b c d e f “Physiological functions of the HECT family of ubiquitin ligases”. Nat. Rev. Mol. Cell Biol. 10 (6): 398–409. (Jun 2009). doi:10.1038/nrm2690. PMID 19436320.
- ^ “Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension”. Hypertension 51 (3): 773–7. (Mar 2008). doi:10.1161/HYPERTENSIONAHA.107.102061. PMID 18268134.
- ^ a b c “Nedd4-2 isoforms differentially associate with ENaC and regulate its activity”. Am. J. Physiol. Renal Physiol. 289 (2): F334-46. (Aug 2005). doi:10.1152/ajprenal.00394.2004. PMID 15814530.
- ^ a b “Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains”. Am. J. Physiol. Renal Physiol. 285 (5): F916-29. (Nov 2003). doi:10.1152/ajprenal.00203.2003. PMID 12876068.
- ^ a b “Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension”. J. Clin. Invest. 123 (2): 657–65. (Feb 1, 2013). doi:10.1172/JCI61110. PMC: 3561795. PMID 23348737.
- ^ “Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2”. J. Biol. Chem. 279 (28): 28930–5. (Jul 9, 2004). doi:10.1074/jbc.M402820200. PMID 15123669.
- ^ “A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel”. FASEB J. 15 (1): 204–214. (Jan 2001). doi:10.1096/fj.00-0191com. PMID 11149908.
- ^ “Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2”. J. Biol. Chem. 282 (16): 12135–42. (Apr 20, 2007). doi:10.1074/jbc.M609385200. PMID 17322297.
- ^ “Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling”. Mol. Cell 36 (3): 457–68. (Nov 13, 2009). doi:10.1016/j.molcel.2009.09.043. PMC: 2796330. PMID 19917253.
- ^ “NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling”. Dev. Biol. 392 (1): 15–25. (Aug 1, 2014). doi:10.1016/j.ydbio.2014.05.003. PMID 24833518.
- ^ “NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains”. J. Virol. 82 (10): 4884–97. (May 2008). doi:10.1128/JVI.02667-07. PMC: 2346761. PMID 18321968.
- ^ “Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins”. EMBO Rep. 10 (5): 501–7. (May 2009). doi:10.1038/embor.2009.30. PMC: 2680872. PMID 19343052.
- ^ “Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins”. BioEssays 28 (6): 617–28. (Jun 2006). doi:10.1002/bies.20422. PMID 16700065.
- ^ “cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2”. J. Biol. Chem. 279 (44): 45753–8. (Oct 29, 2004). doi:10.1074/jbc.M407858200. PMID 15328345.
- ^ “Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3”. Mol. Endocrinol. 19 (12): 3073–84. (Dec 2005). doi:10.1210/me.2005-0193. PMID 16099816.
- ^ “Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2”. J. Biol. Chem. 282 (41): 29866–73. (Oct 12, 2007). doi:10.1074/jbc.M701923200. PMID 17715136.
- ^ “14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels”. Biochemistry 45 (21): 6733–40. (May 30, 2006). doi:10.1021/bi052640q. PMID 16716084.
- ^ “Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain”. Biochem. J. 415 (1): 155–63. (Oct 1, 2008). doi:10.1042/BJ20071708. PMID 18498246.
- ^ “Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2”. Am. J. Physiol. Renal Physiol. 301 (1): F189-96. (Jul 2011). doi:10.1152/ajprenal.00487.2010. PMID 21478478.
- ^ a b “Respiratory distress and perinatal lethality in Nedd4-2-deficient mice”. Nat Commun 2 (4): 287. (2011). doi:10.1038/ncomms1284. PMC: 3104547. PMID 21505443.
- ^ “Nedd4-2 and the regulation of epithelial sodium transport”. Front Physiol 3: 212. (2012). doi:10.3389/fphys.2012.00212. PMC: 3380336. PMID 22737130.
- ^ “Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease”. Proc. Natl. Acad. Sci. U.S.A. 108 (8): 3216–21. (Feb 22, 2011). doi:10.1073/pnas.1010334108. PMC: 3044364. PMID 21300902.
- ^ “NEDD4L in essential hypertension”. J. Hypertens. 32 (2): 230–2. (Feb 2014). doi:10.1097/HJH.0000000000000105. PMID 24430119.
- ^ “Association of NEDD4L ubiquitin ligase with essential hypertension”. Hypertension 46 (3): 488–91. (Sep 2005). doi:10.1161/01.HYP.0000178594.63193.c0. PMID 16103266.
- ^ “Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth”. Proc. Natl. Acad. Sci. U.S.A. 111 (36): 13205–10. (Sep 9, 2014). doi:10.1073/pnas.1400737111. PMC: 4246980. PMID 25157163.
- ^ “Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons”. Biochem. J. 457 (1): 27–31. (Jan 1, 2014). doi:10.1042/BJ20131275. PMID 24152020.
- ^ “Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain”. J. Clin. Invest. 123 (7): 3002–13. (Jul 1, 2013). doi:10.1172/JCI68996. PMC: 3696561. PMID 23778145.
- ^ “Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain”. Neuroscience 227: 370–80. (Dec 27, 2012). doi:10.1016/j.neuroscience.2012.09.044. PMID 23022218.
- ^ “Identification of new partners of the epithelial sodium channel alpha subunit”. Comptes Rendus Biologies 326 (7): 615–24. (Jul 2003). doi:10.1016/s1631-0691(03)00154-9. PMID 14556380.
[続きの解説]
「NEDD4L」の続きの解説一覧
- 1 NEDD4Lとは
- 2 NEDD4Lの概要
- 3 タンパク質構造
- 4 臨床的意義
- 5 関連文献
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