マトリックスメタロプロテイナーゼ-2 マトリックスメタロプロテイナーゼ-2の概要

MMP2
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1CK7, 1CXW, 1EAK, 1GEN, 1GXD, 1HOV, 1J7M, 1KS0, 1QIB, 1RTG, 3AYU
識別子
記号	MMP2, CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, matrix metallopeptidase 2
外部ID	OMIM: 120360 MGI: 97009 HomoloGene: 3329 GeneCards: MMP2
遺伝子の位置 (ヒト)
染色体	16番染色体 (ヒト)
終点	55,506,691 bp
遺伝子の位置 (マウス)
染色体	8番染色体 (マウス)
終点	93,580,048 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• zinc ion binding; • 金属イオン結合; • ペプチダーゼ活性; • 血漿タンパク結合; • metalloendopeptidase activity; • 加水分解酵素活性; • メタロペプチダーゼ活性; • serine-type endopeptidase activity;
細胞の構成要素	• 細胞質; • 膜; • 細胞膜; • サルコメア; • 細胞外領域; • ミトコンドリア; • 細胞核; • 細胞外マトリックス; • 細胞外空間; • collagen-containing extracellular matrix;
生物学的プロセス	• 膜内骨化; • 低酸素症への反応; • endodermal cell differentiation; • ephrin receptor signaling pathway; • skeletal system morphogenesis; • extracellular matrix disassembly; • bone trabecula formation; • タンパク質分解; • 血管新生; • positive regulation of innate immune response; • collagen catabolic process; • cellular response to amino acid stimulus; • face morphogenesis; • embryo implantation; • blood vessel maturation; • positive regulation of vascular associated smooth muscle cell proliferation; • サイトカイン媒介シグナル伝達経路; • extracellular matrix organization; • cellular response to reactive oxygen species; • positive regulation of smooth muscle cell proliferation; • tissue remodeling; • response to amyloid-beta;
	出典:Amigo / QuickGO
オルソログ
	4313
	17390
	ENSG00000087245
	ENSMUSG00000031740
	P08253,H3BR66
	P33434
	NM_004530; NM_001127891; NM_001302508; NM_001302509; NM_001302510
	NM_008610
	NP_001121363; NP_001289437; NP_001289438; NP_001289439; NP_004521
	NP_032636
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087245 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031740 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Structure and expression of neutrophil gelatinase cDNA. Identity with type IV collagenase from HT1080 cells”. J. Biol. Chem. 267 (35): 25228–32. (December 1992). doi:10.1016/S0021-9258(19)74029-0. PMID 1460022.
^ “MMP2 gene”. Genetics Home Reference. 2015年5月19日閲覧。
^ “MMP2 matrix metallopeptidase 2 [Homo sapiens (human) - Gene - NCBI]” (英語). www.ncbi.nlm.nih.gov. 2024年3月25日閲覧。
^ Itoh, Yoshifumi; Seiki, Motoharu (2004-06). “MT1-MMP: an enzyme with multidimensional regulation”. Trends in Biochemical Sciences 29 (6): 285–289. doi:10.1016/j.tibs.2004.04.001. ISSN 0968-0004. PMID 15276180.
^ “Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome”. Nature Genetics 28 (3): 261–5. (July 2001). doi:10.1038/90100. PMID 11431697.
^ ^a ^b “Multicentric Osteolysis, Nodulosis, and Arthropathy in two unrelated children with matrix metalloproteinase 2 variants: Genetic-skeletal correlations”. Bone Reports 15: 101106. (December 2021). doi:10.1016/j.bonr.2021.101106. PMC 8283316. PMID 34307793.
^ “Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias”. American Journal of Respiratory and Critical Care Medicine 162 (5): 1949–56. (November 2000). doi:10.1164/ajrccm.162.5.9906096. PMID 11069839.
^ “Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis”. Annals of the American Thoracic Society 12 (5): 701–7. (May 2015). doi:10.1513/AnnalsATS.201411-513OC. PMID 25679336.
^ “A novel microbiota stratification system predicts future exacerbations in bronchiectasis”. Annals of the American Thoracic Society 11 (4): 496–503. (May 2014). doi:10.1513/AnnalsATS.201310-335OC. PMID 24592925.
^ “Clinical and mutation profile of multicentric osteolysis nodulosis and arthropathy”. American Journal of Medical Genetics. Part A 170A (2): 410–417. (February 2016). doi:10.1002/ajmg.a.37447. PMID 26601801.
^ ^a ^b ^c “Gelatinase-mediated migration and invasion of cancer cells”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1755 (1): 37–69. (May 2005). doi:10.1016/j.bbcan.2005.03.001. hdl:10138/22049. PMID 15907591.
^ ^a ^b ^c ^d “The role of gelatinases in colorectal cancer progression and metastasis”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1705 (2): 69–89. (December 2004). doi:10.1016/j.bbcan.2004.09.006. PMID 15588763.
^ “The regulation of MMP targeting to invadopodia during cancer metastasis”. Frontiers in Cell and Developmental Biology 3: 4. (2015). doi:10.3389/fcell.2015.00004. PMC 4313772. PMID 25699257.
^ “Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia”. Cancer Research 67 (9): 4227–35. (May 2007). doi:10.1158/0008-5472.CAN-06-3928. PMID 17483334.
^ “Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting”. The FEBS Journal 278 (1): 16–27. (Jan 2011). doi:10.1111/j.1742-4658.2010.07919.x. PMID 21087457.
^ ^a ^b “Matrix metalloproteinases: multifunctional contributors to tumor progression”. Molecular Medicine Today 6 (4): 149–56. (April 2000). doi:10.1016/s1357-4310(00)01686-5. PMID 10740253.
^ “Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen”. Proceedings of the National Academy of Sciences of the United States of America 91 (19): 8856–60. (September 1994). Bibcode: 1994PNAS...91.8856M. doi:10.1073/pnas.91.19.8856. PMC 44705. PMID 7522323.
^ “Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5”. Science 277 (5323): 225–28. (July 1997). doi:10.1126/science.277.5323.225. PMID 9211848.
^ “Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase”. Blood 119 (21): 5048–56. (May 2012). doi:10.1182/blood-2011-12-400267. PMID 22490679.
^ “TGFbeta in Cancer”. Cell 134 (2): 215–30. (July 2008). doi:10.1016/j.cell.2008.07.001. PMC 3512574. PMID 18662538.
^ “Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis”. Nature Cell Biology 2 (10): 737–44. (October 2000). doi:10.1038/35036374. PMC 2852586. PMID 11025665.
^ “Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma”. International Journal of Clinical and Experimental Pathology 3 (8): 775–81. (2010). PMC 2993228. PMID 21151391.
^ “Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3”. Science 289 (5482): 1202–6. (August 2000). Bibcode: 2000Sci...289.1202M. doi:10.1126/science.289.5482.1202. PMID 10947989.
^ ^a ^b “Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity”. J. Biol. Chem. 275 (41): 32167–73. (October 2000). doi:10.1074/jbc.M003834200. PMID 10900205.
^ “Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2”. Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7414–9. (May 2002). Bibcode: 2002PNAS...99.7414M. doi:10.1073/pnas.102185399. PMC 124245. PMID 12032297.
^ “Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation”. J. Biol. Chem. 275 (50): 39497–506. (December 2000). doi:10.1074/jbc.M005932200. PMID 10991943.
^ ^a ^b “Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2”. J. Biol. Chem. 272 (24): 15496–500. (June 1997). doi:10.1074/jbc.272.24.15496. PMID 9182583.
^ ^a ^b “Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain”. J. Biol. Chem. 277 (50): 48696–707. (December 2002). doi:10.1074/jbc.M209177200. PMID 12374789.

[前の解説]

[続きの解説]

「マトリックスメタロプロテイナーゼ-2」の続きの解説一覧

1 マトリックスメタロプロテイナーゼ-2とは
2 マトリックスメタロプロテイナーゼ-2の概要
3 機能
4 関連文献
5 外部リンク

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087245 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031740 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid1460022-5] “Structure and expression of neutrophil gelatinase cDNA. Identity with type IV collagenase from HT1080 cells”. J. Biol. Chem. 267 (35): 25228–32. (December 1992). doi:10.1016/S0021-9258(19)74029-0. PMID 1460022.

[:1-6] “MMP2 gene”. Genetics Home Reference. 2015年5月19日閲覧。

[7] “MMP2 matrix metallopeptidase 2 [Homo sapiens (human) - Gene - NCBI]” (英語). www.ncbi.nlm.nih.gov. 2024年3月25日閲覧。

[8] Itoh, Yoshifumi; Seiki, Motoharu (2004-06). “MT1-MMP: an enzyme with multidimensional regulation”. Trends in Biochemical Sciences 29 (6): 285–289. doi:10.1016/j.tibs.2004.04.001. ISSN 0968-0004. PMID 15276180.

[pmid11431697-9] “Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome”. Nature Genetics 28 (3): 261–5. (July 2001). doi:10.1038/90100. PMID 11431697.

[Elsebaie-10] “Multicentric Osteolysis, Nodulosis, and Arthropathy in two unrelated children with matrix metalloproteinase 2 variants: Genetic-skeletal correlations”. Bone Reports 15: 101106. (December 2021). doi:10.1016/j.bonr.2021.101106. PMC 8283316. PMID 34307793.

[pmid11069839-11] “Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias”. American Journal of Respiratory and Critical Care Medicine 162 (5): 1949–56. (November 2000). doi:10.1164/ajrccm.162.5.9906096. PMID 11069839.

[pmid25679336-12] “Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis”. Annals of the American Thoracic Society 12 (5): 701–7. (May 2015). doi:10.1513/AnnalsATS.201411-513OC. PMID 25679336.

[pmid24592925-13] “A novel microbiota stratification system predicts future exacerbations in bronchiectasis”. Annals of the American Thoracic Society 11 (4): 496–503. (May 2014). doi:10.1513/AnnalsATS.201310-335OC. PMID 24592925.

[:2-14] “Clinical and mutation profile of multicentric osteolysis nodulosis and arthropathy”. American Journal of Medical Genetics. Part A 170A (2): 410–417. (February 2016). doi:10.1002/ajmg.a.37447. PMID 26601801.

[:0-15] “Gelatinase-mediated migration and invasion of cancer cells”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1755 (1): 37–69. (May 2005). doi:10.1016/j.bbcan.2005.03.001. hdl:10138/22049. PMID 15907591.

[Mook_2004-16] “The role of gelatinases in colorectal cancer progression and metastasis”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1705 (2): 69–89. (December 2004). doi:10.1016/j.bbcan.2004.09.006. PMID 15588763.

[:3-17] “The regulation of MMP targeting to invadopodia during cancer metastasis”. Frontiers in Cell and Developmental Biology 3: 4. (2015). doi:10.3389/fcell.2015.00004. PMC 4313772. PMID 25699257.

[:4-18] “Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia”. Cancer Research 67 (9): 4227–35. (May 2007). doi:10.1158/0008-5472.CAN-06-3928. PMID 17483334.

[:5-19] “Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting”. The FEBS Journal 278 (1): 16–27. (Jan 2011). doi:10.1111/j.1742-4658.2010.07919.x. PMID 21087457.

[McCawley_2000-20] “Matrix metalloproteinases: multifunctional contributors to tumor progression”. Molecular Medicine Today 6 (4): 149–56. (April 2000). doi:10.1016/s1357-4310(00)01686-5. PMID 10740253.

[:6-21] “Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen”. Proceedings of the National Academy of Sciences of the United States of America 91 (19): 8856–60. (September 1994). Bibcode: 1994PNAS...91.8856M. doi:10.1073/pnas.91.19.8856. PMC 44705. PMID 7522323.

[:7-22] “Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5”. Science 277 (5323): 225–28. (July 1997). doi:10.1126/science.277.5323.225. PMID 9211848.

[:8-23] “Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase”. Blood 119 (21): 5048–56. (May 2012). doi:10.1182/blood-2011-12-400267. PMID 22490679.

[:9-24] “TGFbeta in Cancer”. Cell 134 (2): 215–30. (July 2008). doi:10.1016/j.cell.2008.07.001. PMC 3512574. PMID 18662538.

[:10-25] “Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis”. Nature Cell Biology 2 (10): 737–44. (October 2000). doi:10.1038/35036374. PMC 2852586. PMID 11025665.

[:11-26] “Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma”. International Journal of Clinical and Experimental Pathology 3 (8): 775–81. (2010). PMC 2993228. PMID 21151391.

[pmid10947989-27] “Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3”. Science 289 (5482): 1202–6. (August 2000). Bibcode: 2000Sci...289.1202M. doi:10.1126/science.289.5482.1202. PMID 10947989.

[pmid10900205-28] “Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity”. J. Biol. Chem. 275 (41): 32167–73. (October 2000). doi:10.1074/jbc.M003834200. PMID 10900205.

[pmid12032297-29] “Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2”. Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7414–9. (May 2002). Bibcode: 2002PNAS...99.7414M. doi:10.1073/pnas.102185399. PMC 124245. PMID 12032297.

[pmid10991943-30] “Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation”. J. Biol. Chem. 275 (50): 39497–506. (December 2000). doi:10.1074/jbc.M005932200. PMID 10991943.

[pmid9182583-31] “Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2”. J. Biol. Chem. 272 (24): 15496–500. (June 1997). doi:10.1074/jbc.272.24.15496. PMID 9182583.

[pmid12374789-32] “Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain”. J. Biol. Chem. 277 (50): 48696–707. (December 2002). doi:10.1074/jbc.M209177200. PMID 12374789.

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マトリックスメタロプロテイナーゼ-2 マトリックスメタロプロテイナーゼ-2の概要

マトリックスメタロプロテイナーゼ-2

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