プレクチン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/12 13:37 UTC 版)
プレクチン（英: plectin）は、ほぼすべての哺乳類の細胞に見つかる巨大なタンパク質で、細胞骨格の3つの主要な構成要素であるアクチンマイクロフィラメント、微小管、中間径フィラメントの間の連結部として機能する[5]。加えてプレクチンは、異なる細胞を構造的に連結している細胞膜のジャンクションと細胞骨格とを結合する。これらの異なるネットワークを結び付けることによって、プレクチンは組織の機械的完全性や粘弾性の維持に重要な役割を果たす[6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000178209 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022565 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton”. The Journal of Cell Biology 135 (4): 991–1007. (Nov 1996). doi:10.1083/jcb.135.4.991. PMC 2133373. PMID 8922382.
- ^ a b c d e f “Role of plectin in cytoskeleton organization and dynamics” (abstract). Journal of Cell Science 111 (17): 2477–86. (Sep 1998). PMID 9701547.
- ^ Zong, N. C.; Li, H; Li, H; Lam, M. P.; Jimenez, R. C.; Kim, C. S.; Deng, N; Kim, A. K. et al. (2013). “Integration of cardiac proteome biology and medicine by a specialized knowledgebase”. Circulation Research 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
- ^ “The many faces of plectin and plectinopathies: pathology and mechanisms”. Acta Neuropathologica 125 (1): 77–93. (Jan 2013). doi:10.1007/s00401-012-1026-0. PMID 22864774.
- ^ “Actin-binding domain of mouse plectin. Crystal structure and binding to vimentin”. European Journal of Biochemistry / FEBS 271 (10): 1873–84. (May 2004). doi:10.1111/j.1432-1033.2004.04095.x. PMID 15128297.
- ^ “Morphological integrity of single adult cardiac myocytes isolated by collagenase treatment: immunolocalization of tubulin, microtubule-associated proteins 1 and 2, plectin, vimentin, and vinculin”. European Journal of Cell Biology 38 (1): 113–22. (Jul 1985). PMID 2992982.
- ^ a b “Plectin is a linker of intermediate filaments to Z-discs in skeletal muscle fibers”. Journal of Cell Science 112 (6): 867–76. (Mar 1999). PMID 10036236.
- ^ a b c d e “Plectin: a cytolinker by design”. Biological Chemistry 380 (2): 151–8. (Feb 1999). doi:10.1515/BC.1999.023. PMID 10195422.
- ^ a b “Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin”. The Journal of Biological Chemistry 262 (3): 1320–5. (Jan 1987). PMID 3027087.
- ^ a b “Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin”. Journal of Immunology 167 (2): 641–5. (Jul 2001). doi:10.4049/jimmunol.167.2.641. PMID 11441066.
- ^ “Plectin interacts with the rod domain of type III intermediate filament proteins desmin and vimentin”. European Journal of Cell Biology 90 (5): 390–400. (May 2011). doi:10.1016/j.ejcb.2010.11.013. PMID 21296452.
- ^ “Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture”. Genes & Development 11 (23): 3143–56. (Dec 1997). doi:10.1101/gad.11.23.3143. PMC 316746. PMID 9389647.
- ^ “Association of mitochondria with plectin and desmin intermediate filaments in striated muscle”. Experimental Cell Research 252 (2): 479–91. (Nov 1999). doi:10.1006/excr.1999.4626. PMID 10527638.
- ^ “Structure and function of desmosomal proteins and their role in development and disease”. Cellular and Molecular Life Sciences 60 (9): 1872–90. (Sep 2003). doi:10.1007/s00018-003-3050-7. PMID 14523549.
- ^ “Plakins in development and disease”. Experimental Cell Research 313 (10): 2189–203. (Jun 2007). doi:10.1016/j.yexcr.2007.03.039. PMID 17499243.
- ^ Thorolfsdottir, Rosa B.; Sveinbjornsson, Gardar; Sulem, Patrick; Helgadottir, Anna; Gretarsdottir, Solveig; Benonisdottir, Stefania; Magnusdottir, Audur; Davidsson, Olafur B. et al. (2017). “A Missense Variant in PLEC Increases Risk of Atrial Fibrillation”. Journal of the American College of Cardiology 70 (17): 2157–2168. doi:10.1016/j.jacc.2017.09.005. PMC 5704994. PMID 29050564.
- ^ “Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation”. Neuromuscular Disorders 25 (2): 165–8. (Feb 2015). doi:10.1016/j.nmd.2014.09.011. PMID 25454730.
- ^ a b “Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma”. PLoS Medicine 5 (4): e85. (Apr 2008). doi:10.1371/journal.pmed.0050085. PMC 2292750. PMID 18416599.
- ^ “Plectin-1 as a novel biomarker for pancreatic cancer”. Clinical Cancer Research 17 (2): 302–9. (Jan 2011). doi:10.1158/1078-0432.CCR-10-0999. PMC 3044444. PMID 21098698.
[続きの解説]
「プレクチン」の続きの解説一覧
- 1 プレクチンとは
- 2 プレクチンの概要
- 3 構造
- 4 機能
- 5 臨床的意義
- プレクチンのページへのリンク
