レチノイン酸受容体α
(ra-ra から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/08/10 09:33 UTC 版)
レチノイン酸受容体α（英: retinoic acid receptor alpha、略称: RARα）またはNR1B1（nuclear receptor subfamily 1, group B, member 1）は、ヒトではRARA遺伝子にコードされる核内受容体である[5][6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131759 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037992 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ “Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia”. Blood 91 (8): 2634–42. (April 1998). doi:10.1182/blood.V91.8.2634.2634_2634_2642. PMID 9531570.
- ^ “Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways”. Blood 99 (8): 2637–46. (April 2002). doi:10.1182/blood.V99.8.2637. PMID 11929748.
- ^ “SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia”. Proceedings of the National Academy of Sciences of the United States of America 94 (17): 9028–33. (August 1997). Bibcode: 1997PNAS...94.9028H. doi:10.1073/pnas.94.17.9028. PMC 23013. PMID 9256429.
- ^ “Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation”. The Journal of Biological Chemistry 279 (1): 319–25. (January 2004). doi:10.1074/jbc.M307621200. PMID 14581481.
- ^ “Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity”. Biochemistry 42 (4): 971–9. (February 2003). doi:10.1021/bi020497k. PMID 12549917.
- ^ “RIP-140 interacts with multiple nuclear receptors by means of two distinct sites”. Molecular and Cellular Biology 16 (11): 6029–36. (November 1996). doi:10.1128/MCB.16.11.6029. PMC 231605. PMID 8887632.
- ^ “An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors”. Science 272 (5266): 1336–9. (May 1996). Bibcode: 1996Sci...272.1336S. doi:10.1126/science.272.5266.1336. PMID 8650544.
- ^ “Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)”. Molecular Endocrinology 12 (10): 1551–7. (October 1998). doi:10.1210/mend.12.10.0184. PMID 9773978.
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- ^ “A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins”. Nature Genetics 23 (3): 287–95. (November 1999). doi:10.1038/15463. PMID 10610177.
- ^ “Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter”. Molecular and Cellular Biology 22 (13): 4522–34. (July 2002). doi:10.1128/MCB.22.13.4522-4534.2002. PMC 133906. PMID 12052862.
- ^ “RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors”. The EMBO Journal 11 (4): 1409–18. (April 1992). doi:10.1002/j.1460-2075.1992.tb05186.x. PMC 556590. PMID 1314167.
- ^ “Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation”. Molecular and Cellular Biology 19 (9): 6323–32. (September 1999). doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.
- ^ “Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Molecular and Cellular Biology 23 (6): 2135–50. (March 2003). doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
- ^ “Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator”. The Journal of Biological Chemistry 277 (47): 45611–8. (November 2002). doi:10.1074/jbc.M208447200. PMID 12235159.
- ^ “PLZF is a negative regulator of retinoic acid receptor transcriptional activity”. Nuclear Receptor 1 (1): 6. (September 2003). doi:10.1186/1478-1336-1-6. PMC 212040. PMID 14521715.
[続きの解説]
「レチノイン酸受容体α」の続きの解説一覧
- 1 レチノイン酸受容体αとは
- 2 レチノイン酸受容体αの概要
- 3 機能
- 4 関連文献
- 5 関連項目
- レチノイン酸受容体αのページへのリンク
