HNF4A
(HNF4α から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/06/30 10:11 UTC 版)
HNF4AまたはHNF4α（hepatocyte nuclear factor 4 alpha）、NR2A1（nuclear receptor subfamily 2, group A, member 1）は、ヒトではHNF4A遺伝子にコードされる核内受容体である[5][6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000101076 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017950 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver”. Gene 147 (2): 269–72. (Sep 1994). doi:10.1016/0378-1119(94)90079-5. PMID 7926813.
- ^ “Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17”. Human Genetics 99 (2): 233–6. (Feb 1997). doi:10.1007/s004390050345. PMID 9048927.
- ^ “Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha”. 2023年6月7日閲覧。
- ^ “The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4”. Nature Medicine 9 (2): 220–4. (Feb 2003). doi:10.1038/nm815. PMID 12514743.
- ^ “Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity”. Hepatology 48 (2): 635–45. (2008). doi:10.1002/hep.22396. PMID 18666237.
- ^ “Effect of HNF4α genetic polymorphism G60D on the pharmacokinetics of CYP2D6 substrate tolterodine in healthy Korean individuals”. Pharmacogenetics and Genomics 23 (3): 175–9. (2013). doi:10.1097/FPC.0b013e32835de25e. PMID 23292115.
- ^ “Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY)”. Vitamins and Hormones 95: 407–23. (2014). doi:10.1016/B978-0-12-800174-5.00016-8. PMID 24559927.
- ^ “Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases”. Scientific Reports 9 (1): 18577. (December 2019). Bibcode: 2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.
- ^ “Proteogenomic characterization of human colon and rectal cancer”. Nature 513 (7518): 382–7. (2014). Bibcode: 2014Natur.513..382.. doi:10.1038/nature13438. PMC 4249766. PMID 25043054.
- ^ “Proximal renal tubular acidosis with and without Fanconi syndrome”. Kidney Research and Clinical Practice 38 (3): 267–281. (September 2019). doi:10.23876/j.krcp.19.056. PMC 6727890. PMID 31474092.
- ^ “Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis”. Oncogene 22 (36): 5602–13. (Aug 2003). doi:10.1038/sj.onc.1206802. PMID 12944908.
- ^ “Functional association between CBP and HNF4 in trans-activation”. Biochemical and Biophysical Research Communications 241 (3): 664–9. (Dec 1997). doi:10.1006/bbrc.1997.7871. PMID 9434765.
- ^ “CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression”. The Journal of Biological Chemistry 274 (13): 9013–21. (Mar 1999). doi:10.1074/jbc.274.13.9013. PMID 10085149.
- ^ a b “Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205”. Molecular Endocrinology 16 (7): 1502–10. (Jul 2002). doi:10.1210/mend.16.7.0883. PMID 12089346.
- ^ a b “TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4”. Molecular and Cellular Biology 22 (15): 5626–37. (Aug 2002). doi:10.1128/MCB.22.15.5626-5637.2002. PMC 133960. PMID 12101254.
- ^ “The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression”. Molecular and Cellular Biology 20 (1): 187–95. (Jan 2000). doi:10.1128/MCB.20.1.187-195.2000. PMC 85074. PMID 10594021.
- ^ “Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4”. The Journal of Biological Chemistry 278 (11): 9353–60. (Mar 2003). doi:10.1074/jbc.M205944200. PMID 12522137.
[続きの解説]
「HNF4A」の続きの解説一覧
- 1 HNF4Aとは
- 2 HNF4Aの概要
- 3 機能
- 4 関連文献
- 5 関連項目
- HNF4Aのページへのリンク
