CXCL12
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/02/04 08:03 UTC 版)
CXCL12（C-X-C motif chemokine ligand 12）もしくはSDF-1（stromal cell-derived factor 1）は、ヒトでは10番染色体に位置するCXCL12遺伝子にコードされるケモカインである[5]。CXCL12は多くの組織や細胞種において普遍的に発現している[6]。SDF-1にはSDF-1α、βと呼ばれる種類が存在し、ケモカインファミリーに属する。ケモカインは白血球を活性化し、多くの場合リポ多糖、TNF、IL-1などの炎症性刺激によって誘導される。ケモカインは2つのジスルフィド結合を形成する4つの保存されたシステイン残基によって特徴づけられ、CXCL12はシステイン残基のペアが1アミノ酸によって隔てられているCXCサブファミリーに属する[5]。CXCL12シグナルはいくつかのがんでも観察される[7][8]。CXCL12遺伝子には27種類のSNPが含まれており、冠動脈疾患のリスクの増加と関係している[9]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000107562 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061353 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c “CXCL12 C-X-C motif chemokine ligand 12 [Homo sapiens (human) - Gene - NCBI]” (英語). www.ncbi.nlm.nih.gov. 2023年1月28日閲覧。
- ^ “BioGPS - your Gene Portal System”. biogps.org. 2016年10月11日閲覧。
- ^ a b Guo, Jun-Chao; Li, Jian; Zhou, Li; Yang, Jian-Yu; Zhang, Zhi-Gang; Liang, Zhi-Yong; Zhou, Wei-Xun; You, Lei et al. (2016-09-20). “CXCL12-CXCR7 axis contributes to the invasive phenotype of pancreatic cancer”. Oncotarget 7 (38): 62006–62018. doi:10.18632/oncotarget.11330. ISSN 1949-2553. PMC 5308707. PMID 27542220.
- ^ a b Sorrentino, Claudia; Miele, Lucio; Porta, Amalia; Pinto, Aldo; Morello, Silvana (2016-09-27). “Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression”. Oncotarget 7 (39): 64274–64288. doi:10.18632/oncotarget.11729. ISSN 1949-2553. PMC 5325441. PMID 27590504.
- ^ a b Mega, J. L.; Stitziel, N. O.; Smith, J. G.; Chasman, D. I.; Caulfield, M.; Devlin, J. J.; Nordio, F.; Hyde, C. et al. (2015-06-06). “Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials”. Lancet (London, England) 385 (9984): 2264–2271. doi:10.1016/S0140-6736(14)61730-X. ISSN 1474-547X. PMC 4608367. PMID 25748612.
- ^ a b “CXCL12 - Stromal cell-derived factor 1 precursor - Homo sapiens (Human) - CXCL12 gene & protein”. UniProt. 2023年1月28日閲覧。
- ^ De La Luz Sierra, Maria; Yang, Fuquan; Narazaki, Masashi; Salvucci, Ombretta; Davis, David; Yarchoan, Robert; Zhang, Hongwei H.; Fales, Henry et al. (2004-04-01). “Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity”. Blood 103 (7): 2452–2459. doi:10.1182/blood-2003-08-2857. ISSN 0006-4971. PMID 14525775.
- ^ Crump, M. P.; Gong, J. H.; Loetscher, P.; Rajarathnam, K.; Amara, A.; Arenzana-Seisdedos, F.; Virelizier, J. L.; Baggiolini, M. et al. (1997-12-01). “Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1”. The EMBO journal 16 (23): 6996–7007. doi:10.1093/emboj/16.23.6996. ISSN 0261-4189. PMC 1170303. PMID 9384579.
- ^ Schrader, A. J.; Lechner, O.; Templin, M.; Dittmar, K. E. J.; Machtens, S.; Mengel, M.; Probst-Kepper, M.; Franzke, A. et al. (2002-04-22). “CXCR4/CXCL12 expression and signalling in kidney cancer”. British Journal of Cancer 86 (8): 1250–1256. doi:10.1038/sj.bjc.6600221. ISSN 0007-0920. PMC 2375348. PMID 11953881.
- ^ Custo, Scott; Baron, Byron; Felice, Alex; Seria, Elisa (2022). “A comparative profile of total protein and six angiogenically-active growth factors in three platelet products”. GMS Interdisciplinary plastic and reconstructive surgery DGPW 11: Doc06. doi:10.3205/iprs000167. ISSN 2193-8091. PMC 9284722. PMID 35909816.
- ^ a b Bleul, C. C.; Fuhlbrigge, R. C.; Casasnovas, J. M.; Aiuti, A.; Springer, T. A. (1996-09-01). “A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)”. The Journal of Experimental Medicine 184 (3): 1101–1109. doi:10.1084/jem.184.3.1101. ISSN 0022-1007. PMC 2192798. PMID 9064327.
- ^ Ara, Toshiaki; Nakamura, Yuri; Egawa, Takeshi; Sugiyama, Tatsuki; Abe, Kuniya; Kishimoto, Tadamitsu; Matsui, Yasuhisa; Nagasawa, Takashi (2003-04-29). “Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)”. Proceedings of the National Academy of Sciences of the United States of America 100 (9): 5319–5323. doi:10.1073/pnas.0730719100. ISSN 0027-8424. PMC PMC154343. PMID 12684531.
- ^ Askari, Arman T.; Unzek, Samuel; Popovic, Zoran B.; Goldman, Corey K.; Forudi, Farhad; Kiedrowski, Matthew; Rovner, Aleksandr; Ellis, Stephen G. et al. (2003-08-30). “Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy”. Lancet (London, England) 362 (9385): 697–703. doi:10.1016/S0140-6736(03)14232-8. ISSN 1474-547X. PMID 12957092.
- ^ Ma, Q.; Jones, D.; Borghesani, P. R.; Segal, R. A.; Nagasawa, T.; Kishimoto, T.; Bronson, R. T.; Springer, T. A. (1998-08-04). “Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice”. Proceedings of the National Academy of Sciences of the United States of America 95 (16): 9448–9453. doi:10.1073/pnas.95.16.9448. ISSN 0027-8424. PMC PMC21358. PMID 9689100.
- ^ Takano, Toshio; Li, Yin-Ji; Kukita, Akiko; Yamaza, Takayoshi; Ayukawa, Yasunori; Moriyama, Kanako; Uehara, Norihisa; Nomiyama, Hisayuki et al. (2014-03). “Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis”. Laboratory Investigation; a Journal of Technical Methods and Pathology 94 (3): 286–296. doi:10.1038/labinvest.2013.152. ISSN 1530-0307. PMID 24395111.
- ^ Zheng, Hao; Fu, Guosheng; Dai, Tao; Huang, He (2007-09). “Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway”. Journal of Cardiovascular Pharmacology 50 (3): 274–280. doi:10.1097/FJC.0b013e318093ec8f. ISSN 0160-2446. PMID 17878755.
- ^ Balabanian, Karl; Lagane, Bernard; Infantino, Simona; Chow, Ken Y. C.; Harriague, Julie; Moepps, Barbara; Arenzana-Seisdedos, Fernando; Thelen, Marcus et al. (2005-10-21). “The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes”. The Journal of Biological Chemistry 280 (42): 35760–35766. doi:10.1074/jbc.M508234200. ISSN 0021-9258. PMID 16107333.
- ^ Burns, Jennifer M.; Summers, Bretton C.; Wang, Yu; Melikian, Anita; Berahovich, Rob; Miao, Zhenhua; Penfold, Mark E. T.; Sunshine, Mary Jean et al. (2006-09-04). “A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development”. The Journal of Experimental Medicine 203 (9): 2201–2213. doi:10.1084/jem.20052144. ISSN 0022-1007. PMC 2118398. PMID 16940167.
- ^ Cruz-Orengo, Lillian; Holman, David W.; Dorsey, Denise; Zhou, Liang; Zhang, Penglie; Wright, Melissa; McCandless, Erin E.; Patel, Jigisha R. et al. (2011-02-14). “CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity”. The Journal of Experimental Medicine 208 (2): 327–339. doi:10.1084/jem.20102010. ISSN 1540-9538. PMC 3039853. PMID 21300915.
- ^ Oberlin, E.; Amara, A.; Bachelerie, F.; Bessia, C.; Virelizier, J. L.; Arenzana-Seisdedos, F.; Schwartz, O.; Heard, J. M. et al. (1996-08-29). “The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1”. Nature 382 (6594): 833–835. doi:10.1038/382833a0. ISSN 0028-0836. PMID 8752281.
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- ^ a b “Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair”. Trends in Neurosciences 35 (10): 619–28. (October 2012). doi:10.1016/j.tins.2012.06.003. PMC 3461091. PMID 22784557.
- ^ “CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems”. Frontiers in Cellular Neuroscience 8: 65. (March 2014). doi:10.3389/fncel.2014.00065. PMC 3944789. PMID 24639628.
- ^ “CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems”. Frontiers in Cellular Neuroscience 8: 65. (2014). doi:10.3389/fncel.2014.00065. PMC 3944789. PMID 24639628.
- ^ Pozzobon, Tommaso; Goldoni, Giacomo; Viola, Antonella; Molon, Barbara (2016-09). “CXCR4 signaling in health and disease”. Immunology Letters 177: 6–15. doi:10.1016/j.imlet.2016.06.006. ISSN 1879-0542. PMID 27363619.
- ^ “CXCL12 promoter methylation and PD-L1 expression as prognostic biomarkers in prostate cancer patients”. Oncotarget 7 (33): 53309–53320. (July 2016). doi:10.18632/oncotarget.10786. PMC 5288188. PMID 27462860.
- ^ “Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment”. Brain: A Journal of Neurology 129 (Pt 1): 200–11. (January 2006). doi:10.1093/brain/awh680. PMID 16280350.
- ^ a b “Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity”. Toxicology and Applied Pharmacology 256 (3): 300–13. (November 2011). doi:10.1016/j.taap.2011.06.006. PMC 3236026. PMID 21704645.
- ^ “The autocrine CXCR4/CXCL12 axis contributes to lung fibrosis through modulation of lung fibroblast activity”. Experimental and Therapeutic Medicine 19 (3): 1844–1854. (March 2020). doi:10.3892/etm.2020.8433. PMC 7027131. PMID 32104240.
- ^ Neesse, Albrecht; Ellenrieder, Volker (2017-02). “NEMO-CXCL12/CXCR4 axis: a novel vantage point for antifibrotic therapies in chronic pancreatitis?”. Gut 66 (2): 211–212. doi:10.1136/gutjnl-2016-312874. ISSN 1468-3288. PMID 27590996.
- ^ Welford, Abigail F.; Biziato, Daniela; Coffelt, Seth B.; Nucera, Silvia; Fisher, Matthew; Pucci, Ferdinando; Di Serio, Clelia; Naldini, Luigi et al. (2011-05). “TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice”. The Journal of Clinical Investigation 121 (5): 1969–1973. doi:10.1172/JCI44562. ISSN 1558-8238. PMC 3083764. PMID 21490397.
- ^ De Clercq, Erik (2019). “Mozobil® (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration”. Antiviral Chemistry & Chemotherapy 27: 2040206619829382. doi:10.1177/2040206619829382. ISSN 2040-2066. PMC 6379795. PMID 30776910.
[続きの解説]
「CXCL12」の続きの解説一覧
- 1 CXCL12とは
- 2 CXCL12の概要
- 3 構造
- 4 関連文献
- CXCL12のページへのリンク
