CXCL1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/02 00:14 UTC 版)
CXCL1（C-X-C motif chemokine ligand 1）は、CXCケモカインファミリーに属する低分子量タンパク質である。いくつかの免疫系細胞（特に好中球[3][4]）やその他の非造血系細胞を損傷部位や感染部位へ誘引する化学誘引物質として作用し、免疫応答や炎症応答の調節に重要な役割を果たす。以前はGRO1 oncogene、GROα、NAP-3（neutrophil-activating protein 3）、MGSA-α（melanoma growth stimulating activity, alpha）といった名称で呼ばれていた。CXCL1は、BALB/c-3T3マウス胎児線維芽細胞に対するPDGF刺激によって誘導される遺伝子のcDNAライブラリから初めてクローニングされ、ニトロセルロースコロニーハイブリダイゼーションアッセイ時の位置から"KC"と命名された[5]。この記号は"keratinocytes-derived chemokine"の頭文字をとったものと誤解されていることがある。ラットのCXCL1は、NRK-52E細胞へのIL-1β、LPS刺激によって産生される、好中球を誘引するサイトカイン（cytokine-induced neutrophil chemoattractant, CINC）の特性解析よって報告された[6]。ヒトでは、このタンパク質はCXCL1遺伝子にコードされており[7]、この遺伝子は他のCXCケモカインの遺伝子と共に4番染色体に位置している[8]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163739 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ “Neutrophil-activating properties of the melanoma growth-stimulatory activity”. The Journal of Experimental Medicine 171 (5): 1797–1802. (May 1990). doi:10.1084/jem.171.5.1797. PMC 2187876. PMID 2185333.
- ^ “High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils”. Proceedings of the National Academy of Sciences of the United States of America 89 (21): 10542–10546. (November 1992). Bibcode: 1992PNAS...8910542S. doi:10.1073/pnas.89.21.10542. PMC 50375. PMID 1438244.
- ^ “Molecular cloning of gene sequences regulated by platelet-derived growth factor”. Cell 33 (3): 939–947. (July 1983). doi:10.1016/0092-8674(83)90037-5. PMID 6872001.
- ^ “Purification and characterization of cytokine-induced neutrophil chemoattractant produced by epithelioid cell line of normal rat kidney (NRK-52E cell)”. Biochemical and Biophysical Research Communications 161 (3): 1093–1099. (June 1989). doi:10.1016/0006-291X(89)91355-7. PMID 2662972.
- ^ “Identification of three related human GRO genes encoding cytokine functions”. Proceedings of the National Academy of Sciences of the United States of America 87 (19): 7732–7736. (October 1990). Bibcode: 1990PNAS...87.7732H. doi:10.1073/pnas.87.19.7732. PMC 54822. PMID 2217207.
- ^ “Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin”. The EMBO Journal 7 (7): 2025–2033. (July 1988). doi:10.1002/j.1460-2075.1988.tb03042.x. PMC 454478. PMID 2970963.
- ^ “Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor”. The Journal of Biological Chemistry 288 (17): 12244–12252. (April 2013). doi:10.1074/jbc.m112.443762. PMC 3636908. PMID 23479735.
- ^ “Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue”. Molecular and Cellular Biology 10 (10): 5596–5599. (October 1990). doi:10.1128/mcb.10.10.5596. PMC 361282. PMID 2078213.
- ^ “Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages”. The American Journal of Physiology 266 (3 Pt 1): L278–L286. (March 1994). doi:10.1152/ajplung.1994.266.3.L278. PMID 8166297.
- ^ a b “Th17 cells regulate the production of CXCL1 in breast cancer”. International Immunopharmacology 56: 320–329. (March 2018). doi:10.1016/j.intimp.2018.01.026. PMID 29438938.
- ^ a b “CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization”. Neurobiology of Disease 105: 109–116. (September 2017). doi:10.1016/j.nbd.2017.06.001. PMID 28587921.
- ^ “Delayed wound healing in CXCR2 knockout mice”. The Journal of Investigative Dermatology 115 (2): 234–244. (August 2000). doi:10.1046/j.1523-1747.2000.00034.x. PMC 2664868. PMID 10951241.
- ^ “The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma”. Journal of Leukocyte Biology 67 (1): 53–62. (January 2000). doi:10.1002/jlb.67.1.53. PMC 2669312. PMID 10647998.[リンク切れ]
- ^ “Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins”. International Journal of Cancer 73 (1): 94–103. (September 1997). doi:10.1002/(SICI)1097-0215(19970926)73:1<94::AID-IJC15>3.0.CO;2-5. PMID 9334815.
- ^ “CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space”. Angiogenesis 18 (2): 163–171. (April 2015). doi:10.1007/s10456-014-9454-1. PMID 25490937.
- ^ “Complementary action of CXCL1 and CXCL8 in pathogenesis of gastric carcinoma”. International Journal of Clinical and Experimental Pathology 11 (2): 1036–1045. (2018-02-01). PMC 6958037. PMID 31938199.
- ^ “Interaction between Tumor-Associated Dendritic Cells and Colon Cancer Cells Contributes to Tumor Progression via CXCL1”. International Journal of Molecular Sciences 19 (8): 2427. (August 2018). doi:10.3390/ijms19082427. PMC 6121631. PMID 30115896.
- ^ “Role of CXC group chemokines in lung cancer development and progression”. Journal of Thoracic Disease 9 (Suppl 3): S164–S171. (April 2017). doi:10.21037/jtd.2017.03.61. PMC 5392545. PMID 28446981.
- ^ “Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells”. Proceedings of the National Academy of Sciences of the United States of America 84 (20): 7188–7192. (October 1987). Bibcode: 1987PNAS...84.7188A. doi:10.1073/pnas.84.20.7188. PMC 299255. PMID 2890161.
- ^ “Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution”. Journal of Cellular Biochemistry 36 (2): 185–198. (February 1988). doi:10.1002/jcb.240360209. PMID 3356754.
- ^ “Role of CXCL1 in tumorigenesis of melanoma”. Journal of Leukocyte Biology 72 (1): 9–18. (July 2002). doi:10.1189/jlb.72.1.9. PMC 2668262. PMID 12101257.
- ^ “The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration”. Cell 110 (3): 373–383. (August 2002). doi:10.1016/S0092-8674(02)00838-3. PMID 12176324.
- ^ “Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1”. The American Journal of Pathology 174 (1): 164–176. (January 2009). doi:10.2353/ajpath.2009.080350. PMC 2631329. PMID 19095949.
[続きの解説]
「CXCL1」の続きの解説一覧
- 1 CXCL1とは
- 2 CXCL1の概要
- 3 構造と発現
- 4 神経系と感作における役割
- CXCL1のページへのリンク
