サイクリンA2
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/11 10:18 UTC 版)
サイクリンA2（英: cyclin A2）は、ヒトではCCNA2遺伝子にコードされるタンパク質である[5]。2種類存在するサイクリンAのうちの1つであり、サイクリンA1が主に減数分裂と胚発生の過程で発現するのに対し、サイクリンA2は細胞分裂を行う体細胞で発現している[6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145386 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027715 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “A TaqI polymorphism in the human cyclin A gene”. Nucleic Acids Res. 19 (9): 2516. (July 1991). doi:10.1093/nar/19.9.2516. PMC 329485. PMID 1675006.
- ^ a b c d e “Cyclin A in cell cycle control and cancer”. Cell. Mol. Life Sci. 59 (8): 1317–1326. (Aug 2002). doi:10.1007/s00018-002-8510-y. PMID 12363035.
- ^ “Cyclin A is required at two points in the human cell cycle”. EMBO J. 11 (3): 961–971. (March 1992). doi:10.1002/j.1460-2075.1992.tb05135.x. PMC 556537. PMID 1312467.
- ^ “Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor”. Mol. Biol. Cell 18 (5): 1861–1873. (Mar 2007). doi:10.1091/mbc.E06-12-1092. PMC 1855023. PMID 17344473.
- ^ “The roles of cyclin A2, B1, and B2 in early and late mitotic events”. Mol. Biol. Cell 21 (18): 3149–3161. (Sep 2010). doi:10.1091/mbc.E10-05-0393. PMC 2938381. PMID 20660152.
- ^ a b c d “Structure and cell cycle-regulated transcription of the human cyclin A gene”. Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5490–5494. (Jun 1994). doi:10.1073/pnas.91.12.5490. PMC 44021. PMID 8202514.
- ^ a b “Cyclin-dependent kinases and S phase control in mammalian cells”. Cell Cycle 2 (4): 316–324. (Jul–Aug 2003). doi:10.4161/cc.2.4.468. PMID 12851482.
- ^ a b “Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation”. Mol. Cell. Biol. 14 (12): 8420–8431. (1994). doi:10.1128/MCB.14.12.8420. PMC 359381. PMID 7969176.
- ^ a b c d e f “Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes”. Sci Transl Med 6 (224): 224ra27. (2014). doi:10.1126/scitranslmed.3007668. PMID 24553388.
- ^ “Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2”. J. Thorac. Cardiovasc. Surg. 133 (4): 927–933. (2007). doi:10.1016/j.jtcvs.2006.07.057. PMID 17382628.
- ^ “Heart regeneration”. Nature 473 (7347): 326–335. (2011). doi:10.1038/nature10147. PMC 4091722. PMID 21593865.
- ^ “Over-expression of cyclin A is highly associated with early relapse and reduced survival in patients with primary breast carcinomas”. Int. J. Cancer 93 (2): 283–287. (Jul 2001). doi:10.1002/ijc.1311. PMID 11410878.
- ^ “Immunohistochemical detection of sex steroid receptors, cyclins, and cyclin-dependent kinases in the normal and neoplastic squamous epithelia of the uterine cervix”. Cancer 82 (9): 1709–1719. (May 1998). doi:10.1002/(sici)1097-0142(19980501)82:9<1709::aid-cncr18>3.0.co;2-8. PMID 9576293.
- ^ “Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas”. Anticancer Res. 21 (1B): 657–662. (Jan–Feb 2001). PMID 11299822.
- ^ “Cyclin A is associated with an unfavourable outcome in patients with non-small-cell lung carcinomas”. Br. J. Cancer 75 (12): 1774–1778. (1997). doi:10.1038/bjc.1997.302. PMC 2223613. PMID 9192980.
- ^ “Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase”. J. Cell Biol. 153 (1): 121–136. (Apr 2001). doi:10.1083/jcb.153.1.121. PMC 2185531. PMID 11285279.
- ^ “Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases”. Nature 376 (6535): 88–91. (Jul 1995). doi:10.1038/376088a0. PMID 7596441.
- ^ “Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization”. EMBO J. 18 (2): 396–410. (January 1999). doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.
- ^ “Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase”. Mol. Cell. Biol. 18 (5): 2758–2767. (May 1998). doi:10.1128/mcb.18.5.2758. PMC 110655. PMID 9566895.
- ^ “Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation”. Oncogene 22 (28): 4301–4313. (July 2003). doi:10.1038/sj.onc.1206606. PMID 12853968.
- ^ “beta3-endonexin as a novel inhibitor of cyclin A-associated kinase”. Biochem. Biophys. Res. Commun. 267 (3): 947–952. (January 2000). doi:10.1006/bbrc.1999.2007. PMID 10673397.
- ^ “Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1”. J. Virol. 67 (12): 7641–7647. (December 1993). doi:10.1128/JVI.67.12.7641-7647.1993. PMC 238233. PMID 8230483.
- ^ “B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107”. Oncogene 21 (52): 7923–7932. (November 2002). doi:10.1038/sj.onc.1206001. PMID 12439743.
- ^ “Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2”. J. Biol. Chem. 279 (47): 48707–48715. (November 2004). doi:10.1074/jbc.M405528200. PMID 15355997.
- ^ “Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation”. Nat. Cell Biol. 1 (1): 14–19. (May 1999). doi:10.1038/8984. PMID 10559858.
[続きの解説]
「サイクリンA2」の続きの解説一覧
- 1 サイクリンA2とは
- 2 サイクリンA2の概要
- 3 機能
- 4 相互作用
- サイクリンA2のページへのリンク
