アロマターゼとは - わかりやすく解説 Weblio辞書

アロマターゼ

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/06/05 04:59 UTC 版)

アロマターゼ（Aromatase, EC 1.14.14.14）は、エストロゲンシンテターゼ（estrogen synthetase）またはエストロゲンシンターゼと（estrogen synthase）も呼ばれ、エストロゲンの生合成に関与する酵素である。シトクロムP450スーパーファミリーの一つCYP19A1は、ステロイドの産生に関する様々な反応を触媒するモノオキシゲナーゼである。特に、アロマターゼはアンドロゲンを芳香化（英語版）してエストロゲンに変換する反応に関与している。アロマターゼは、性腺（顆粒膜細胞）、脳、脂肪組織、胎盤、血管、皮膚、骨などの多くの体組織のほか、子宮内膜症や子宮筋腫、乳癌、および子宮体癌の病巣部に見られる^[要出典]。

出典

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