ブイ‐イー‐ジー‐エフ【VEGF】
血管内皮細胞増殖因子
血管内皮成長因子
血管内皮細胞増殖因子
(Vascular endothelial growth factor から転送)
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/09/03 15:23 UTC 版)
血管内皮細胞増殖因子(けっかんないひさいぼうぞうしょくいんし)は、脈管形成(胚形成期に、血管がないところに新たに血管がつくられること)および血管新生(既存の血管から分枝伸長して血管を形成すること)に関与する一群の糖タンパク。英語の vascular endothelial growth factor から VEGF(ブイイージーエフ)と呼ばれることが多い。その他、血管内皮細胞成長因子、血管内皮増殖因子、血管内皮成長因子などと呼ばれることもある。VEGFは主に血管内皮細胞表面にある血管内皮細胞増殖因子受容体 (VEGFR) にリガンドとして結合し、細胞分裂や遊走、分化を刺激したり、微小血管の血管透過性を亢進させたりする働きをもつが、その他単球・マクロファージの活性化にも関与する。正常な体の血管新生に関わる他、腫瘍の血管形成や転移など、悪性化の過程にも関与している。
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- ^ Entrez Gene: VEGFA
- ^ Entrez Gene: VEGFB
- ^ Entrez Gene: VEGFC
- ^ Entrez Gene: FIGF
- ^ Entrez Gene: PGF
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- ^ 日本病院薬剤師会雑誌(2008) 44,863-70.
- 1 血管内皮細胞増殖因子とは
- 2 血管内皮細胞増殖因子の概要
- 3 VEGFを標的にした薬剤
- Vascular endothelial growth factorのページへのリンク