遮断抗体
(阻害抗体 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/04/30 21:24 UTC 版)
遮断抗体（しゃだんこうたい、英: blocking antibody）は、抗原と結合しても反応を起こさず、他の抗体がその抗原と結合するのを防ぐ抗体のことである[1]。遮断抗体のこの機能は、臨床や実験でさまざまな用途がある。
- ^ Blocking Antibodies - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）
- ^ “Blocking antibody access to neutralizing domains on glycoproteins involved in entry as a novel mechanism of immune evasion by herpes simplex virus type 1 glycoproteins C and E”. J. Virol. 82 (14): 6935–41. (July 2008). doi:10.1128/JVI.02599-07. PMC 2446985. PMID 18480440.
- ^ Callahan, Margaret (March 26, 2013). “At the Bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy”. Journal of Leukocyte Biology 94: 41–53. doi:10.1189/jlb.1212631. PMC 4051187. PMID 23667165.
- ^ a b c Kyi, Chrisann (October 23, 2013). “Checkpoint blocking antibodies in cancer immunotherapy”. Federation of European Biochemical Societies Letters.
- ^ Valente, William (July 19, 1982). “Monoclonal antibodies to the thyrotropin receptor: Stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease”. Proceedings of the National Academy of Sciences 79: 6680–6684. doi:10.1073/pnas.79.21.6680. PMC 347192. PMID 6292912.
- ^ Uthaipibull, Chairat (April 13, 2001). “Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum”. Journal of Molecular Biology 307: 1381–1394. doi:10.1006/jmbi.2001.4574.
- ^ Blackman, MJ (July 1996). “Plasmodium knowlesi: secondary processing of the malaria merozoite surface protein-1.”. Experimental Parasitology 83: 229–39. doi:10.1006/expr.1996.0069. PMID 8682191.
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