染色体凝縮
英訳・(英)同義/類義語：chromosome condensation, Mitotic chromosomes
細胞分裂の中期に、核内に分散していた染色体が集合し、染色体ごとにまとまった形態をとる過程。染色体上で不活性な領域（ヘテロクロマチン）が形成される過程。
細胞分裂の中期に、核内に分散していた染色体が集合し、染色体ごとにまとまった形態をとる過程。染色体上で不活性な領域（ヘテロクロマチン）が形成される過程。
「生物学用語辞典」の他の用語
| 細胞名や細胞内の構造オルガネラに関連する用語： | 有精卵 未受精卵 条件的ヘテロクロマチン 染色体凝縮 栄養胞子 核 核小体 |
染色体凝縮
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/04/23 08:28 UTC 版)
染色体凝縮（せんしょくたいぎょうしゅく：chromosome condensation）とは、間期の細胞核内に分散していたクロマチンが、細胞分裂期においてコンパクトな棒状の構造に変換する過程のことをいう（図１）[1][2][3][4][5]。染色体構築あるいは染色体形成とも呼ばれる。
- ^ Swedlow JR, Hirano T (2003). “The making of the mitotic chromosome: modern insights into classical questions”. Mol. Cell 11: 557-569. PMID 12667441.
- ^ Belmont AS (2006). “Mitotic chromosome structure and condensation”. Curr Opin Cell Biol. 18: 632-638. PMID 17046228.
- ^ Marko JF (2008). “Micromechanical studies of mitotic chromosomes”. Chromosome Res. 16: 469-497. PMID 18461485.
- ^ Batty P, Gerlich DW (2019). “Mitotic chromosome mechanics: How cells segregate their genome”. Trends Cell Biol.: 717-726. PMID 31230958.
- ^ Paulson JR, Hudson DF, Cisneros-Soberanis F, Earnshaw WC (2021). “Mitotic chromosomes”. Semin. Cell Dev. Biol.: S1084-9521(21)00061-6. PMID 33836947.
- ^ Hirano T (2004). “Chromosome shaping by two condensins”. Cell Cycle 3: 26-28. PMID 14657659.
- ^ Hirano T (2005). “Condensins: organizing and segregating the genome”. Curr. Biol. 15: R265-275. PMID 15823530.
- ^ Shintomi K, Hirano T (2010). “Sister chromatid resolution: a cohesin releasing network and beyond”. Chromosoma 119: 459-467. PMID 20352243.
- ^ Shintomi K, Takahashi TS, Hirano T (2015). “Reconstitution of mitotic chromatids with a minimum set of purified factors”. Nat Cell Biol 17 (8): 1014-1023. PMID 26075356.
- ^ Shintomi K, Hirano T (2021). “Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly”. Nat Commun 12 (1): 2917. PMID 34006877.
- ^ Shintomi K, Inoue F, Watanabe H, Ohsumi K, Ohsugi M, Hirano T. (2017). "Mitotic chromosome assembly despite nucleosome depletion in Xenopus egg extracts". Science, 356 (6344):1284-1287. PMID 28522692
- ^ Sedat J, Manuelidis L (1978). “A direct approach to the structure of eukaryotic chromosomes”. Cold Spring Harb. Symp. Quant. Biol. 42: 331-350. PMID 98280.
- ^ Paulson JR, Laemmli UK (1977). “The structure of histone-depleted metaphase chromosomes”. Cell 12: 817-828. PMID 922894.
- ^ Marko JF, Siggia ED (1997). “Polymer models of meiotic and mitotic chromosomes”. Mol. Biol. Cell 8: 2217-2231. PMID 9362064.
- ^ Kireeva N, Lakonishok M, Kireev I, Hirano T, Belmont AS (2004). “Visualization of early chromosome condensation: a hierarchical folding, axial glue model of chromosome structure”. J. Cell Biol. 166: 775-785. PMID 15353545.
- ^ Naumova N, Imakaev M, Fudenberg G, Zhan Y, Lajoie BR, Mirny LA, Dekker J (2013). “Organization of the mitotic chromosome”. Science 342: 948-953. PMID 24200812.
- ^ Eagen KP, Hartl A, Kornberg RD (2015). “Stable chromosome condensation revealed by chromosome conformation capture”. Cell 163: 934-946. PMID 26544940.
- ^ Kakui Y, Rabinowitz A, Barry DJ, Uhlmann F (2017). “Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast”. Nat Genet. PMID 28825727.
- ^ Schalbetter SA, Goloborodko A, Fudenberg G, Belton JM, Miles C, Yu M, Dekker J, Mirny L, Baxter J (2017). “SMC complexes differentially compact mitotic chromosomes according to genomic context”. Nat Cell Biol 19: 1071-1080. PMID 28825700.
- ^ Gibcus JH, Samejima K, Goloborodko A, Samejima I, Naumova N, Nuebler J, Kanemaki MT, Xie L, Paulson JR, Earnshaw WC, Mirny LA, Dekker J F (2018). “A pathway for mitotic chromosome formation”. Science: pii: eaao6135. doi: 10.1126/science.aao6135. PMID 29348367.
- ^ Goloborodko A, Imakaev MV, Marko JF, Mirny L (2016). “Compaction and segregation of sister chromatids via active loop extrusion”. eLife 5: doi: 10.7554/eLife.14864. PMID 27192037.
- ^ Cheng TM, Heeger S, Chaleil RA, Matthews N, Stewart A, Wright J, Lim C, Bates PA, Uhlmann F (2015). “A simple biophysical model emulates budding yeast chromosome condensation”. eLife 4: doi: 10.7554/eLife.05565. PMID 25922992.
- ^ Sakai Y, Mochizuki A, Kinoshita K, Hirano T, Tachikawa M. (2018). “Modeling the functions of condensin in chromosome shaping and segregation”. PLoS Comput Biol 14 (6): e1006152. doi: 10.1371/journal.pcbi.1006152. PMID 29912867.
- ^ Pereira SL, Grayling RA, Lurz R, Reeve JN (2006). “Archaeal nucleosomes”. Proc. Natl. Acad. Sci. USA. 94: 12633-12637. PMID 9356501.
- ^ Graumann PL, Knust T (2009). “Dynamics of the bacterial SMC complex and SMC-like proteins involved in DNA repair”. Chromosome Res. 17: 265-275. PMID 19308706.
- ^ Reyes-Lamothe R, Nicolas E, Sherratt DJ (2012). “Chromosome replication and segregation in bacteria”. Annu. Rev. Genet. 46: 121-143. PMID 22934648.
- ^ Wang X, Montero Llopis P, Rudner DZ (2013). “Organization and segregation of bacterial chromosomes”. Nat Rev. Genet. 14: 191-203. PMID 23400100.
- ^ Le TB, Imakaev MV, Mirny LA, Laub MT (2013). “High-resolution mapping of the spatial organization of a bacterial chromosome”. Science 342 (6159): 731-734. PMID 24158908.
- ^ Wang X, Le TB, Lajoie BR, Dekker J, Laub MT, Rudner DZ (2015). “Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis”. Genes Dev. 29 (15): 1661-1675. PMID 26253537.
- ^ Lioy VS, Cournac A, Marbouty M, Duigou S, Mozziconacci J, Espéli O, Boccard F, Koszul R (2018). “Multiscale Structuring of the E. coli Chromosome by Nucleoid-Associated and Condensin Proteins”. Cell 172 (4): 771-783.e18. PMID 29358050.
- ^ Hirano T (2014). “Condensins and the evolution of torsion-mediated genome organization”. Trends Cell Biol. 24 (12): 727-733. PMID 25092191.
[続きの解説]
「染色体凝縮」の続きの解説一覧
- 1 染色体凝縮とは
- 2 染色体凝縮の概要
- 3 分裂期染色体のモデル
- 4 参考図書
- 染色体凝縮のページへのリンク
