プロテインジスルフィドイソメラーゼ
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/03/21 15:17 UTC 版)
プロテインジスルフィドイソメラーゼまたはタンパク質ジスルフィドイソメラーゼ（英: protein disulfide isomerase、略称: PDI）は、真核生物の小胞体や細菌のペリプラズムに存在する酵素で、タンパク質がフォールディングする際にタンパク質内のシステイン残基の間のジスルフィド結合の形成と切断を触媒する[1][2][3]。PDIは、タンパク質が完全にフォールディングした状態で形成される適切なジスルフィド結合パターンの迅速な発見を可能にし、そのためフォールディングを触媒する酵素として作用する。
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- ^ “Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins”. Nature Chemical Biology 6 (12): 900–6. (December 2010). doi:10.1038/nchembio.467. PMC 3018711. PMID 21079601.
- ^ “Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective”. Proceedings of the National Academy of Sciences of the United States of America 112 (17): E2245-52. (April 2015). Bibcode: 2015PNAS..112E2245K. doi:10.1073/pnas.1500439112. PMC 4418888. PMID 25848045.
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[続きの解説]
「プロテインジスルフィドイソメラーゼ」の続きの解説一覧
- 1 プロテインジスルフィドイソメラーゼとは
- 2 プロテインジスルフィドイソメラーゼの概要
- 3 構造
- 4 ストレスと阻害
- 5 外部リンク
- プロテインジスルフィドイソメラーゼのページへのリンク
