VU0155041とは？わかりやすく解説

VU0155041
識別子
	IUPAC名 (1R,2S)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid ;
CAS登録番号	1263273-14-8;
PubChem; CID	888023;
IUPHAR/BPS	3323;
ChemSpider	776108;
ChEMBL	ChEMBL578988;
化学的および物理的データ
化学式	C14H15Cl2NO3
分子量	316.18 g·mol−1
3D model; (JSmol)	Interactive image;
	SMILES C1CC[C@H]([C@H](C1)C(=O)NC2=CC(=CC(=C2)Cl)Cl)C(=O)O ;
	InChI InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)/t11-,12+/m0/s1 ; Key:VSMUYYFJVFSVCA-NWDGAFQWSA-N ;
	テンプレートを表示

VU0155041は、グルタミン酸受容体mGluR4（英語版）に対する陽性アロステリック調節因子である実験薬である。動物実験では、抗パーキンソン病作用を示し、アロディニアなどの神経障害性疼痛を軽減し、オピオイド依存症の作用を打ち消す^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]。

出典

↑ “Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4”. Molecular Pharmacology 74 (5): 1345–1358. (November 2008). doi:10.1124/mol.108.049551. PMC 2574552. PMID 18664603.
↑ “Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)”. Bioorganic & Medicinal Chemistry Letters 19 (17): 4967–4970. (September 2009). doi:10.1016/j.bmcl.2009.07.072. PMC 2752865. PMID 19640716.
↑ “Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain”. NeuroReport 22 (5): 244–248. (March 2011). doi:10.1097/WNR.0b013e3283453843. PMID 21358553.
↑ “Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease”. British Journal of Pharmacology 166 (8): 2317–2330. (August 2012). doi:10.1111/j.1476-5381.2012.01943.x. PMC 3448896. PMID 22404342.
↑ “Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity”. Neuropsychopharmacology 39 (9): 2049–2060. (August 2014). doi:10.1038/npp.2014.59. PMC 4104328. PMID 24619243.
↑ “The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats”. BMC Neuroscience 22 (1): 17. (March 2021). doi:10.1186/s12868-021-00627-2 {{doi}}: 明示されていないフリーアクセスDOI (カテゴリ). PMC 7981834. PMID 33743609.
↑ “Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice”. Neuropsychopharmacology 46 (7): 1373–1385. (June 2021). doi:10.1038/s41386-020-00927-x. PMC 8136479. PMID 33349673.
↑ “VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats”. Brain Research Bulletin 197: 57–64. (June 2023). doi:10.1016/j.brainresbull.2023.03.012. PMID 36997034.
↑ “Red nucleus mGluR4 and mGluR8 inhibit nociception and the development of neuropathic pain by restraining the expressions of TNF-α and IL-1β”. Neuropharmacology 271: 110387. (June 2025). doi:10.1016/j.neuropharm.2025.110387. PMID 40010564.

[1] “Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4”. Molecular Pharmacology 74 (5): 1345–1358. (November 2008). doi:10.1124/mol.108.049551. PMC 2574552. PMID 18664603.

[2] “Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)”. Bioorganic & Medicinal Chemistry Letters 19 (17): 4967–4970. (September 2009). doi:10.1016/j.bmcl.2009.07.072. PMC 2752865. PMID 19640716.

[3] “Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain”. NeuroReport 22 (5): 244–248. (March 2011). doi:10.1097/WNR.0b013e3283453843. PMID 21358553.

[4] “Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease”. British Journal of Pharmacology 166 (8): 2317–2330. (August 2012). doi:10.1111/j.1476-5381.2012.01943.x. PMC 3448896. PMID 22404342.

[5] “Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity”. Neuropsychopharmacology 39 (9): 2049–2060. (August 2014). doi:10.1038/npp.2014.59. PMC 4104328. PMID 24619243.

[6] “The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats”. BMC Neuroscience 22 (1): 17. (March 2021). doi:10.1186/s12868-021-00627-2 {{doi}}: 明示されていないフリーアクセスDOI (カテゴリ). PMC 7981834. PMID 33743609.

[7] “Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice”. Neuropsychopharmacology 46 (7): 1373–1385. (June 2021). doi:10.1038/s41386-020-00927-x. PMC 8136479. PMID 33349673.

[8] “VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats”. Brain Research Bulletin 197: 57–64. (June 2023). doi:10.1016/j.brainresbull.2023.03.012. PMID 36997034.

[9] “Red nucleus mGluR4 and mGluR8 inhibit nociception and the development of neuropathic pain by restraining the expressions of TNF-α and IL-1β”. Neuropharmacology 271: 110387. (June 2025). doi:10.1016/j.neuropharm.2025.110387. PMID 40010564.

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識別子

IUPAC名 (1R,2S)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid
CAS登録番号	1263273-14-8
PubChem CID	888023
IUPHAR/BPS	3323
ChemSpider	776108
ChEMBL	ChEMBL578988
化学的および物理的データ
化学式	C₁₄H₁₅Cl₂NO₃
分子量	316.18 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CC[C@H]([C@H](C1)C(=O)NC2=CC(=CC(=C2)Cl)Cl)C(=O)O
InChI InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)/t11-,12+/m0/s1 Key:VSMUYYFJVFSVCA-NWDGAFQWSA-N
テンプレートを表示

VU0155041とは？ わかりやすく解説

VU0155041

出典

急上昇のことば

英和和英テキスト翻訳

VU0155041とは？わかりやすく解説