U-48800とは？わかりやすく解説

U-48800
識別子
	IUPAC名 2-(2,4-dichlorophenyl)-N-[(1S,2S)-2-(dimethylamino)cyclohexyl]-N-methylacetamide ;
CAS登録番号	2370977-17-4;
PubChem; CID	137700072;
UNII	C1X8MF00M5;
化学的および物理的データ
化学式	C17H24Cl2N2O
分子量	343.29 g·mol−1
3D model; (JSmol)	Interactive image;
	SMILES CN(C)[C@H]1CCCC[C@@H]1N(C)C(=O)CC2=C(C=C(C=C2)Cl)Cl ;
	InChI InChI=1S/C17H24Cl2N2O/c1-20(2)15-6-4-5-7-16(15)21(3)17(22)10-12-8-9-13(18)11-14(12)19/h8-9,11,15-16H,4-7,10H2,1-3H3/t15-,16-/m0/s1 ; Key:FKUWIGXXBMULOI-HOTGVXAUSA-N ;
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U-48800は、デザイナードラッグとして販売されているオピオイド鎮痛薬である。U-47700とは異なり、主にκオピオイド受容体アゴニストとして作用し、μオピオイド受容体に対する親和性は中程度である。しかし、依然として娯楽用薬物市場に出回っており、よく他の薬物との混合成分であり、数多くの薬物過剰摂取事例に関連している^[1]^[2]^[3]^[4]^[5]。

脚注

^ “Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding”. Drug Testing and Analysis 11 (10): 1572–1580. (October 2019). doi:10.1002/dta.2683. PMID 31424163.
^ “U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market”. Brain Sciences 10 (11): 895. (November 2020). doi:10.3390/brainsci10110895. PMC 7700279. PMID 33238449.
^ “Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS-MS and Case Series of Fatalities Involving U-48800”. Journal of Analytical Toxicology 46 (1): 17–24. (February 2022). doi:10.1093/jat/bkaa180. PMID 33237987.
^ “Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [³⁵ S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800”. Drug Testing and Analysis 14 (7): 1187–1199. (July 2022). doi:10.1002/dta.3238. PMID 35142070.
^ “A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists”. Toxicology Letters 382: 41–46. (June 2023). doi:10.1016/j.toxlet.2023.05.010. PMID 37245850.

[pmid31424163-1] “Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding”. Drug Testing and Analysis 11 (10): 1572–1580. (October 2019). doi:10.1002/dta.2683. PMID 31424163.

[pmid33238449-2] “U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market”. Brain Sciences 10 (11): 895. (November 2020). doi:10.3390/brainsci10110895. PMC 7700279. PMID 33238449.

[3] “Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS-MS and Case Series of Fatalities Involving U-48800”. Journal of Analytical Toxicology 46 (1): 17–24. (February 2022). doi:10.1093/jat/bkaa180. PMID 33237987.

[4] “Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [³⁵ S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800”. Drug Testing and Analysis 14 (7): 1187–1199. (July 2022). doi:10.1002/dta.3238. PMID 35142070.

[5] “A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists”. Toxicology Letters 382: 41–46. (June 2023). doi:10.1016/j.toxlet.2023.05.010. PMID 37245850.

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U-48800とは？わかりやすく解説

U-48800

関連項目

脚注

英和和英テキスト翻訳

「U-48800」の関連用語

識別子

IUPAC名 2-(2,4-dichlorophenyl)-N-[(1S,2S)-2-(dimethylamino)cyclohexyl]-N-methylacetamide
CAS登録番号	2370977-17-4
PubChem CID	137700072
UNII	C1X8MF00M5
化学的および物理的データ
化学式	C₁₇H₂₄Cl₂N₂O
分子量	343.29 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)[C@H]1CCCC[C@@H]1N(C)C(=O)CC2=C(C=C(C=C2)Cl)Cl
InChI InChI=1S/C17H24Cl2N2O/c1-20(2)15-6-4-5-7-16(15)21(3)17(22)10-12-8-9-13(18)11-14(12)19/h8-9,11,15-16H,4-7,10H2,1-3H3/t15-,16-/m0/s1 Key:FKUWIGXXBMULOI-HOTGVXAUSA-N
テンプレートを表示

U-48800とは？ わかりやすく解説

U-48800

関連項目

脚注

急上昇のことば

英和和英テキスト翻訳

「U-48800」の関連用語

U-48800とは？わかりやすく解説