Streptomyces cattleyaとは？わかりやすく解説

Streptomyces cattleyaはグラム陽性菌で、セファマイシン^[1]、ペニシリン、チエナマイシンを産生する^[2]^[3] 。この細菌はフルオリナーゼ酵素を発現しており^[4]、この生物はフルオロ酢酸と抗菌性4-フルオロ-L-スレオニンの生合成を理解するために使用されている^[5]^[6]。従来とは異なるアミノ酸であるβ-エチニルセリン（βes）とL-プロパルギルグリシン（Pra）の生合成に至るγ-Glu-βes経路は、この種で初めて特徴づけられた^[7]。

2011年に塩基配列が決定されたゲノムには、6,283,062塩基対の染色体1本と1,809,491bpのメガプラスミド1本が含まれ、全体のグアニン-シトシン含量は73%である^[8]。

脚注

^ Bodner, MJ; Li, R; Phelan, RM; Freeman, MF; Moshos, KA; Lloyd, EP; Townsend, CA (Sep 19, 2011). “Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis.”. ChemBioChem 12 (14): 2159–65. doi:10.1002/cbic.201100366. PMC 3281309. PMID 21913298.
^ Kahan, JS; Kahan, FM; Goegelman, R; Currie, SA; Jackson, M; Stapley, EO; Miller, TW; Miller, AK et al. (Jan 1979). “Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.”. The Journal of Antibiotics 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.
^ “Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties”. J. Antibiot. 32 (1): 1–12. (1979). doi:10.7164/antibiotics.32.1. PMID 761989.
^ O'Hagan, David; Schaffrath, Christoph; Cobb, Steven L.; Hamilton, John T. G.; Murphy, Cormac D. (March 2002). “Biochemistry: Biosynthesis of an organofluorine molecule”. Nature 416 (6878): 279. Bibcode: 2002Natur.416..279O. doi:10.1038/416279a. PMID 11907567.
^ Zhao, C; Li, P; Deng, Z; Ou, HY; McGlinchey, RP; O'Hagan, D (Oct 2012). “Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants.”. Bioorganic Chemistry 44: 1–7. doi:10.1016/j.bioorg.2012.06.002. PMID 22858315.
^ Reid, KA; Hamilton, JT; Bowden, RD; O'Hagan, D; Dasaradhi, L; Amin, MR; Harper, DB (Jun 1995). “Biosynthesis of fluorinated secondary metabolites by Streptomyces cattleya.”. Microbiology 141 (6): 1385–93. doi:10.1099/13500872-141-6-1385. PMID 7670640.
^ Kuehnel, Karin (May 2019). “A bacterial treasure trove”. Nature Methods 16 (5): 360. doi:10.1038/s41592-019-0411-1. PMID 31040424. (要購読契約)
^ Barbe, V; Bouzon, M; Mangenot, S; Badet, B; Poulain, J; Segurens, B; Vallenet, D; Marlière, P et al. (Sep 2011). “Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites.”. Journal of Bacteriology 193 (18): 5055–6. doi:10.1128/JB.05583-11. PMC 3165681. PMID 21868806.

[1] Bodner, MJ; Li, R; Phelan, RM; Freeman, MF; Moshos, KA; Lloyd, EP; Townsend, CA (Sep 19, 2011). “Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis.”. ChemBioChem 12 (14): 2159–65. doi:10.1002/cbic.201100366. PMC 3281309. PMID 21913298.

[2] Kahan, JS; Kahan, FM; Goegelman, R; Currie, SA; Jackson, M; Stapley, EO; Miller, TW; Miller, AK et al. (Jan 1979). “Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.”. The Journal of Antibiotics 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.

[3] “Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties”. J. Antibiot. 32 (1): 1–12. (1979). doi:10.7164/antibiotics.32.1. PMID 761989.

[4] O'Hagan, David; Schaffrath, Christoph; Cobb, Steven L.; Hamilton, John T. G.; Murphy, Cormac D. (March 2002). “Biochemistry: Biosynthesis of an organofluorine molecule”. Nature 416 (6878): 279. Bibcode: 2002Natur.416..279O. doi:10.1038/416279a. PMID 11907567.

[5] Zhao, C; Li, P; Deng, Z; Ou, HY; McGlinchey, RP; O'Hagan, D (Oct 2012). “Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants.”. Bioorganic Chemistry 44: 1–7. doi:10.1016/j.bioorg.2012.06.002. PMID 22858315.

[6] Reid, KA; Hamilton, JT; Bowden, RD; O'Hagan, D; Dasaradhi, L; Amin, MR; Harper, DB (Jun 1995). “Biosynthesis of fluorinated secondary metabolites by Streptomyces cattleya.”. Microbiology 141 (6): 1385–93. doi:10.1099/13500872-141-6-1385. PMID 7670640.

[7] Kuehnel, Karin (May 2019). “A bacterial treasure trove”. Nature Methods 16 (5): 360. doi:10.1038/s41592-019-0411-1. PMID 31040424. (要購読契約)

[8] Barbe, V; Bouzon, M; Mangenot, S; Badet, B; Poulain, J; Segurens, B; Vallenet, D; Marlière, P et al. (Sep 2011). “Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites.”. Journal of Bacteriology 193 (18): 5055–6. doi:10.1128/JB.05583-11. PMC 3165681. PMID 21868806.

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Streptomyces cattleyaとは？ わかりやすく解説

Streptomyces cattleya

脚注

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Streptomyces cattleyaとは？わかりやすく解説