TFIIH
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/04/02 14:38 UTC 版)
TFIIH（transcription factor II H）は、さまざまな遺伝子の転写やヌクレオチド除去修復（NER）経路に関与するタンパク質複合体である。1989年にin vitro転写に不可欠な転写因子として特性解析がなされたことで、TFIIHの存在は明らかとなった。この因子は酵母からも単離され、最終的に1992年にTFIIHと命名された[1][2]。
- ^ “Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH”. The Journal of Biological Chemistry 267 (4): 2786–93. (February 1992). doi:10.1016/S0021-9258(18)45947-9. PMID 1733973.
- ^ “Mechanism of ATP-dependent promoter melting by transcription factor IIH”. Science 288 (5470): 1418–22. (May 2000). Bibcode: 2000Sci...288.1418K. doi:10.1126/science.288.5470.1418. PMID 10827951.
- ^ Kolesnikova, Olga; Radu, Laura; Poterszman, Arnaud (2019). “TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair”. Advances in Protein Chemistry and Structural Biology 115: 21–67. doi:10.1016/bs.apcsb.2019.01.003. ISSN 1876-1631. PMID 30798933.
- ^ “The essential and multifunctional TFIIH complex”. Protein Science 27 (6): 1018–1037. (June 2018). doi:10.1002/pro.3424. PMC 5980561. PMID 29664212.
- ^ “Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II”. Nature 368 (6473): 769–72. (April 1994). Bibcode: 1994Natur.368..769D. doi:10.1038/368769a0. PMID 8152490.
- ^ “Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II”. Nature 368 (6473): 769–72. (April 1994). Bibcode: 1994Natur.368..769D. doi:10.1038/368769a0. PMID 8152490.
- ^ “Transcription of eukaryotic protein-coding genes”. Annual Review of Genetics 34: 77–137. (2000). doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
- ^ “TFIIH: when transcription met DNA repair”. Nature Reviews. Molecular Cell Biology 13 (6): 343–54. (May 2012). doi:10.1038/nrm3350. PMID 22572993.
- ^ “Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo”. Molecular Cell 10 (5): 1163–74. (November 2002). doi:10.1016/s1097-2765(02)00709-8. PMID 12453423.
- ^ “TFIIH is an elongation factor of RNA polymerase I”. Nucleic Acids Research 40 (2): 650–9. (January 2012). doi:10.1093/nar/gkr746. PMC 3258137. PMID 21965540.
- ^ a b “TTDA: big impact of a small protein”. Experimental Cell Research 329 (1): 61–8. (November 2014). doi:10.1016/j.yexcr.2014.07.008. PMID 25016283.
- ^ “Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms”. Biomolecules 5 (3): 1855–69. (August 2015). doi:10.3390/biom5031855. PMC 4598778. PMID 26287260.
- ^ “Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome”. Human Mutation 27 (11): 1092–103. (November 2006). doi:10.1002/humu.20392. PMID 16947863.
- ^ “TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus”. Cell 116 (4): 541–50. (February 2004). doi:10.1016/s0092-8674(04)00132-1. PMID 14980221.
- ^ “A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia”. iScience 23 (9): 101536. (2020). Bibcode: 2020iSci...23j1536D. doi:10.1016/j.isci.2020.101536. PMC 7509213. PMID 33083765.
[続きの解説]
「TFIIH」の続きの解説一覧
- 1 TFIIHとは
- 2 TFIIHの概要
- 3 疾患
- TFIIHのページへのリンク
