RNAポリメラーゼI
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/04/02 14:41 UTC 版)
RNAポリメラーゼI(英: RNA polymerase I、略称: Pol I)は、高等真核生物ではリボソームRNA(ただしRNAポリメラーゼIIIによって合成される5S rRNAを除く)のみを転写するポリメラーゼである。このタイプのRNAは、細胞内で合成されるRNAの総量の50%以上を占める[1]。
- ^ Russell, Jackie; Zomerdijk, Joost C B M (2006). “The RNA polymerase I transcription machinery”. Biochemical Society Symposium (73): 203–16. PMC 3858827. PMID 16626300 .
- ^ Engel, Christoph; Sainsbury, Sarah; Cheung, Alan C.; Kostrewa, Dirk; Cramer, Patrick (23 October 2013). “RNA polymerase I structure and transcription regulation”. Nature 502 (7473): 650–655. doi:10.1038/nature12712. hdl:11858/00-001M-0000-0015-3B48-5. PMID 24153182 2014年12月16日閲覧。.
- ^ Zentner, Gabriel E; Saiakhova, Alina; Manaenkov, Pavel; Adams, Mark D; Scacheri, Peter C (25 February 2011). “Integrative genomic analysis of human ribosomal DNA”. Nucleic Acids Research 39 (12): 4949–4960. doi:10.1093/nar/gkq1326. PMC 3130253. PMID 21355038 2014年12月16日閲覧。.
- ^ Edger, Patrick P; Tang, Michelle; Bird, Kevin A; Mayfield, Dustin R; Conant, Gavin; Mummenhoff, Klaus; Koch, Marcus A; Pires, J Chris (1 July 2014). “Secondary structure analyses of the nuclear rRNA internal transcribed spacers and assessment of its phylogenetic utility across the Brassicaceae (mustards)”. PLoS ONE 9 (7): e101341. doi:10.1371/journal.pone.0101341. PMC 4077792. PMID 24984034 .
- ^ Appling, Dean; Anthony-Cahill, Spencer; Mathews, Christopher (2016). Biochemistry: Concepts and Connections. Hoboken, New Jersey: Pearson. pp. 742. ISBN 978-0-321-83992-3
- ^ Watkins, Nicholas J.; Bohnsack, Markus T. (May 2012). “The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA”. Wiley Interdisciplinary Reviews: RNA 3 (3): 397–414. doi:10.1002/wrna.117. PMID 22065625.
- ^ a b Venema, Jaap; Tollervey, David (December 1999). “Ribosome Synthesis in Saccharomyces cerevisiae”. Annual Review of Genetics 33 (1): 261–311. doi:10.1146/annurev.genet.33.1.261. PMID 10690410.
- ^ Grandori, Carla; Gomez-Roman, Natividad; Felton-Edkins, Zoe A.; Ngouenet, Celine; Galloway, Denise A.; Eisenman, Robert N.; White, Robert J. (20 February 2005). “c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I”. Nature Cell Biology 7 (3): 311–318. doi:10.1038/ncb1224. PMID 15723054 2014年12月16日閲覧。.
- ^ 村山明子 (2009). “代謝ストレス応答とrRNA転写制御機構”. 生化学 81: 456-464. NAID 10025187853 .
- ^ Russell, Jackie; Zomerdijk, Joost C. B. M. (2005-2). “RNA-polymerase-I-directed rDNA transcription, life and works”. Trends in Biochemical Sciences 30 (2): 87–96. doi:10.1016/j.tibs.2004.12.008. ISSN 0968-0004. PMC PMCPMC3858833. PMID 15691654 .
- ^ Conconi, A.; Widmer, R. M.; Koller, T.; Sogo, J. M. (1989-06-02). “Two different chromatin structures coexist in ribosomal RNA genes throughout the cell cycle”. Cell 57 (5): 753–761. ISSN 0092-8674. PMID 2720786 .
- ^ Jantzen, Hans-Michael; Admon, Arie; Bell, Stephen P.; Tjian, Robert (26 April 1990). “Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins”. Nature 344 (6269): 830–836. doi:10.1038/344830a0. PMID 2330041 2014年12月16日閲覧。.
- ^ a b Grummt, Ingrid (15 July 2003). “Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus”. Genes & Development 17 (14): 1691–1702. doi:10.1101/gad.1098503R. PMID 12865296 2014年12月16日閲覧。.
- ^ Learned, R Marc; Cordes, Sabine; Tjian, Robert (June 1985). “Purification and characterization of a transcription factor that confers promoter specificity to human RNA polymerase I”. Molecular and Cellular Biology 5 (6): 1358–69. doi:10.1128/MCB.5.6.1358. PMC 366865. PMID 3929071 2014年12月16日閲覧。.
- ^ Clos, Joachim; Buttgereit, Detlev; Grummt, Ingrid (February 1986). “A purified transcription factor (TIF-IB) binds to essential sequences of the mouse rDNA promoter”. Proceedings of the National Academy of Sciences of the United States of America 83 (3): 604–8. doi:10.1073/pnas.83.3.604. PMC 322912. PMID 3456157 2014年12月16日閲覧。.
- ^ a b c Russell, Jackie; Zomerdijk, Joost C. B. M. (2005-2). “RNA-polymerase-I-directed rDNA transcription, life and works”. Trends in Biochemical Sciences 30 (2): 87–96. doi:10.1016/j.tibs.2004.12.008. ISSN 0968-0004. PMC PMCPMC3858833. PMID 15691654 .
- ^ “Transcription-mediated hyper-recombination in HOT1”. Genes Cells 9 (4): 305–15. (2004). doi:10.1111/j.1356-9597.2004.00729.x. PMID 15066122.
- 1 RNAポリメラーゼIとは
- 2 RNAポリメラーゼIの概要
- 3 組換えホットスポット
- RNAポリメラーゼIのページへのリンク