モノアミン酸化酵素
(モノアミンオキシダーゼ から転送)
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2020/09/30 14:56 UTC 版)
モノアミン酸化酵素(モノアミンさんかこうそ)またはモノアミンオキシダーゼ(英: monoamine oxidase、略称: MAO、EC 1.4.3.4)は、モノアミンの酸化を触媒する酵素ファミリーであり、酸素を用いてモノアミンからアミンを除去する[1][2]。体中の大部分の細胞種でミトコンドリア外膜に結合して存在している。1928年にMary Bernheimによって肝臓に発見され、チラミンオキシダーゼ(tyramine oxidase)と名付けられた[3][4]。MAOはフラビン含有アミンオキシドレダクターゼファミリーに属する。
- ^ “Monoamine oxidases: certainties and uncertainties”. Current Medicinal Chemistry 11 (15): 1965–82. (August 2004). doi:10.2174/0929867043364810. PMID 15279561.
- ^ “Structure and mechanism of monoamine oxidase”. Current Medicinal Chemistry 11 (15): 1983–93. (August 2004). doi:10.2174/0929867043364784. PMID 15279562.
- ^ “Tyramine oxidase: A new enzyme system in liver”. The Biochemical Journal 22 (4): 968–79. (1928). doi:10.1042/bj0220968. PMC: 1252213. PMID 16744124 .
- ^ “Mary Bernheim and the discovery of monoamine oxidase”. Brain Research Bulletin 50 (5–6): 373. (1999). doi:10.1016/S0361-9230(99)00110-0. PMID 10643441.
- ^ Yeung AWK, Georgieva MG, Atanasov AG, Tzvetkov NT. Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature Analysis. Front Mol Neurosci. 2019 May 29;12:143. doi: 10.3389/fnmol.2019.00143.
- ^ “Regulation of MAO-A and MAO-B gene expression”. Current Medicinal Chemistry 11 (15): 1995–2005. (August 2004). doi:10.2174/0929867043364757. PMID 15279563.
- ^ “Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies”. Journal of Cerebral Blood Flow and Metabolism 33 (6): 863–71. (June 2013). doi:10.1038/jcbfm.2013.19. PMC: 3677103. PMID 23403377 .
- ^ Figure 11-4 in: Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. (2007). ISBN 978-0-443-06911-6
- ^ “Structures and Mechanism of the Monoamine Oxidase Family”. Biomolecular Concepts 2 (5): 365–377. (October 2011). doi:10.1515/BMC.2011.030. PMC: 3197729. PMID 22022344 .
- ^ “Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors”. Chemical Research in Toxicology 14 (9): 1139–62. (September 2001). doi:10.1021/tx010073b. PMID 11559028.
- ^ “Decreased blood platelet MAO activity in unmedicated chronic schizophrenic patients”. The American Journal of Psychiatry 133 (3): 323–6. (March 1976). doi:10.1176/ajp.133.3.323. PMID 943955.
- ^ “Reduced platelet monoamine oxidase activity in a subgroup of schizophrenic patients”. The American Journal of Psychiatry 133 (4): 438–40. (April 1976). doi:10.1176/ajp.133.4.438. PMID 1267046.
- ^ “Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression”. Archives of General Psychiatry 63 (11): 1209–16. (November 2006). doi:10.1001/archpsyc.63.11.1209. PMID 17088501.
- ^ “Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children”. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 134B (1): 110–4. (April 2005). doi:10.1002/ajmg.b.30158. PMID 15717295.
- ^ “Platelet monoamine oxidase, personality and alcoholism: the rise, fall and resurrection”. Neurotoxicology 25 (1–2): 79–89. (January 2004). doi:10.1016/S0161-813X(03)00115-3. PMID 14697883.
- ^ “Monoamine oxidase activities in patients with migraine or with cluster headache during the acute phases and after treatment with L-5-hydroxytryptophan”. Rivista di Patologia Nervosa e Mentale 100 (5): 269–74. (1 October 2016). PMID 318025.
- ^ “Monoamine oxidases A and B gene polymorphisms in migraine patients”. Journal of the Neurological Sciences 228 (2): 149–53. (February 2005). doi:10.1016/j.jns.2004.11.045. PMID 15694196.
- ^ “Clinical applications of MAO-inhibitors”. Current Medicinal Chemistry 11 (15): 2033–43. (August 2004). doi:10.2174/0929867043364775. PMID 15279566.
- ^ “The role of monoamine oxidase inhibitors in current psychiatric practice”. Journal of Psychiatric Practice 10 (4): 239–48. (July 2004). doi:10.1097/00131746-200407000-00005. PMC: 2075358. PMID 15552546 .
- ^ “Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition”. Journal of Addictive Diseases 17 (1): 23–34. (1998). doi:10.1300/J069v17n01_03. PMID 9549600.
- ^ “Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain”. Psychopharmacology 72 (1): 27–33. (1980). doi:10.1007/bf00433804. PMID 6781004.
- ^ “Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B”. Neurotoxicology 25 (1–2): 21–30. (January 2004). doi:10.1016/s0161-813x(03)00112-8. PMID 14697877.
- ^ Brunner, H. G.; Nelen, M.; Breakefield, X. O.; Ropers, H. H.; van Oost, B. A. (1993-10-22). “Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A”. Science (New York, N.Y.) 262 (5133): 578–580. doi:10.1126/science.8211186. ISSN 0036-8075. PMID 8211186 .
- ^ “Monoamine oxidase A gene promoter polymorphism affects novelty seeking and reward dependence in healthy study participants”. Psychiatric Genetics 16 (2): 55–8. (April 2006). doi:10.1097/01.ypg.0000199447.62044.ef. PMID 16538181.
- ^ “Role of genotype in the cycle of violence in maltreated children”. Science 297 (5582): 851–4. (August 2002). doi:10.1126/science.1072290. PMID 12161658.
- ^ Sesardic, Neven (2005). Making sense of heritability. Cambridge, UK: Cambridge University Press. ISBN 978-0-521-82818-5
- ^ a b Merriman, Tony; Cameron, Vicky (2007-03-02). “Risk-taking: behind the warrior gene story”. The New Zealand Medical Journal 120 (1250): U2440. ISSN 1175-8716. PMID 17339896 .
- ^ “A functional polymorphism in the monoamine oxidase A gene promoter”. Human Genetics 103 (3): 273–9. (September 1998). doi:10.1007/s004390050816. PMID 9799080 .
- ^ Lea, Rod; Chambers, Geoffrey (2007-03-02). “Monoamine oxidase, addiction, and the "warrior" gene hypothesis”. The New Zealand Medical Journal 120 (1250): U2441. ISSN 1175-8716. PMID 17339897 .
- ^ G. Raumati Hook (2009). ““Warrior genes” and the disease of being Māori”. MAI Review (2): Target Article.
- ^ “Monoamine oxidase expression during development and aging”. Neurotoxicology 25 (1–2): 155–65. (January 2004). doi:10.1016/S0161-813X(03)00095-0. PMID 14697890.
- ^ a b “Monoamine oxidase activity in the rat pineal gland: Comparison with brain areas and alteration during aging”. Advances in Gerontology 6 (2): 111–116. (2016-07-14). doi:10.1134/S2079057016020120. ISSN 2079-0570.
- 1 モノアミン酸化酵素とは
- 2 モノアミン酸化酵素の概要
- 3 基質特異性
- 4 老化
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