上皮性ナトリウムチャネル
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/12 13:41 UTC 版)
上皮性ナトリウムチャネル（じょうひせいナトリウムチャネル、英: epithelial sodium channel、略称: ENaC）またはアミロライド感受性ナトリウムチャネル（amiloride-sensitive sodium channel）は膜に結合したイオンチャネルで、ナトリウムイオン（Na+）を選択的に透過させる。ENaCは3つの相同なサブユニット、α（またはδ）、β、γから構成されるヘテロ三量体である[2]。これらのサブユニットは4つの遺伝子、SCNN1A、SCNN1B、SCNN1G、SCNN1Dにコードされている。ENaCは、主に腎臓のネフロンの集合管でのナトリウムイオンの再吸収に関与している。
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- ^ “Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition response”. The FEBS Journal 281 (8): 2097–111. (Apr 2014). doi:10.1111/febs.12765. PMID 24571549.
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- ^ “ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family”. Functional and Phylogenetic Classification of Membrane Transport Proteins. Saier Lab. Group, UCSD and SDSC. 2019年11月19日閲覧。
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- ^ “Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice”. Nature Medicine 10 (5): 487–93. (May 2004). doi:10.1038/nm1028. PMID 15077107.
- ^ “Transgenic hCFTR expression fails to correct β-ENaC mouse lung disease”. American Journal of Physiology. Lung Cellular and Molecular Physiology 302 (2): L238-47. (January 2012). doi:10.1152/ajplung.00083.2011. PMC 3349361. PMID 22003093.
- ^ “Ion transporting proteins of human bronchial epithelium”. Journal of Cellular Biochemistry 113 (2): 426–32. (Feb 2012). doi:10.1002/jcb.23393. PMID 21975871.
- ^ Ion Channel Diseases
[続きの解説]
「上皮性ナトリウムチャネル」の続きの解説一覧
- 1 上皮性ナトリウムチャネルとは
- 2 上皮性ナトリウムチャネルの概要
- 3 ファミリー
- 4 外部リンク
- 上皮性ナトリウムチャネルのページへのリンク
