Sp1転写因子
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/10/09 02:22 UTC 版)
Sp1転写因子（specificity protein 1）は、ヒトではSP1遺伝子によってコードされるタンパク質である[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185591 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001280 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b “Entrez Gene: Sp1 transcription factor”. 2021年10月3日閲覧。
- ^ Guaraldo, Michela; Santambrogio, Paolo; Rovelli, Elisabetta; Di Savino, Augusta; Saglio, Giuseppe; Cittaro, Davide; Roetto, Antonella; Levi, Sonia (2016-09-14). “Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control”. Scientific Reports 6: 33432. doi:10.1038/srep33432. ISSN 2045-2322. PMC 5022048. PMID 27625068.
- ^ “Iron loss triggers mitophagy through induction of mitochondrial ferritin”. EMBO Reports 21 (11): e50202. (November 2020). doi:10.15252/embr.202050202. PMID 32975364.
- ^ Zhang, Bosen; Song, Liwei; Cai, Jiali; Li, Lei; Xu, Hong; Li, Mengying; Wang, Jiamin; Shi, Minmin et al. (2019). “The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation” (英語). Journal of Experimental & Clinical Cancer Research 38 (1): 205. doi:10.1186/s13046-019-1203-2. ISSN 1756-9966. PMC 6525466. PMID 31101117.
- ^ “The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes”. Molecular and Cellular Biology 23 (6): 1843–55. (March 2003). doi:10.1128/MCB.23.6.1843-1855.2003. PMC 149455. PMID 12612060.
- ^ “Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer”. Scientific Reports 4: 7162. (November 2014). Bibcode: 2014NatSR...4E7162C. doi:10.1038/srep07162. PMC 4241519. PMID 25418289.
- ^ “Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription”. Current Trends in Biotechnology and Pharmacy 3 (2): 138–148. (2009).[リンク切れ]
- ^ “miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells”. Aging 11 (18): 7357–7385. (September 2019). doi:10.18632/aging.102214. PMC 6781994. PMID 31543507.
- ^ a b “Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter”. The Journal of Biological Chemistry 278 (38): 36496–504. (September 2003). doi:10.1074/jbc.M306694200. PMID 12847090.
- ^ “Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages”. Journal of Immunology 171 (2): 821–8. (July 2003). doi:10.4049/jimmunol.171.2.821. PMID 12847250.
- ^ a b “A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription”. Molecular and Cellular Biology 23 (8): 2720–32. (April 2003). doi:10.1128/MCB.23.8.2720-2732.2003. PMC 152545. PMID 12665574.
- ^ “Positive regulation of human alpha 1 (I) collagen promoter activity by transcription factor Sp1”. Gene 164 (2): 229–34. (October 1995). doi:10.1016/0378-1119(95)00508-4. PMID 7590335.
- ^ “Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction”. Molecular and Cellular Biology 16 (4): 1668–75. (April 1996). doi:10.1128/mcb.16.4.1668. PMC 231153. PMID 8657142.
- ^ “Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter”. Journal of Molecular Biology 293 (5): 1005–15. (November 1999). doi:10.1006/jmbi.1999.3213. PMID 10547281.
- ^ “Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F”. Molecular and Cellular Biology 16 (4): 1659–67. (April 1996). doi:10.1128/mcb.16.4.1659. PMC 231152. PMID 8657141.
- ^ “FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription”. Molecular and Cellular Biology 33 (6): 1198–209. (March 2013). doi:10.1128/MCB.01054-12. PMC 3592019. PMID 23319049.
- ^ “Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter”. Journal of Molecular Biology 306 (5): 985–96. (March 2001). doi:10.1006/jmbi.2000.4335. PMID 11237613.
- ^ “Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex”. Oncogene 21 (12): 1812–22. (March 2002). doi:10.1038/sj.onc.1205252. PMID 11896613.
- ^ a b “Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex”. The Journal of Biological Chemistry 277 (36): 33431–8. (September 2002). doi:10.1074/jbc.M204417200. PMID 12091390.
- ^ a b “The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2”. The Journal of Biological Chemistry 277 (39): 35783–6. (September 2002). doi:10.1074/jbc.C200378200. PMID 12176973.
- ^ “Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells”. The Journal of Biological Chemistry 277 (41): 38230–8. (October 2002). doi:10.1074/jbc.M206064200. PMID 12151407.
- ^ a b “A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening”. Molecular and Cellular Biochemistry 210 (1–2): 131–42. (July 2000). doi:10.1023/A:1007177623283. PMID 10976766.
- ^ “Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1”. Genes & Development 17 (7): 896–911. (April 2003). doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
- ^ “Interaction of Huntington disease protein with transcriptional activator Sp1”. Molecular and Cellular Biology 22 (5): 1277–87. (March 2002). doi:10.1128/MCB.22.5.1277-1287.2002. PMC 134707. PMID 11839795.
- ^ “Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury”. Blood 100 (12): 4001–10. (December 2002). doi:10.1182/blood.V100.12.4001. PMID 12433697.
- ^ “Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1”. The Journal of Biological Chemistry 273 (40): 26218–24. (October 1998). doi:10.1074/jbc.273.40.26218. PMID 9748305.
- ^ “Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter”. Molecular Immunology 39 (1–2): 25–30. (September 2002). doi:10.1016/S0161-5890(02)00055-X. PMID 12213324.
- ^ “Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)”. The Biochemical Journal 339 ( Pt 3) (3): 751–8. (May 1999). doi:10.1042/0264-6021:3390751. PMC 1220213. PMID 10215616.
- ^ “Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter”. Molecular and Cellular Biology 19 (4): 2577–84. (April 1999). doi:10.1128/mcb.19.4.2577. PMC 84050. PMID 10082523.
- ^ “The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression”. Nucleic Acids Research 24 (11): 1981–6. (June 1996). doi:10.1093/nar/24.11.1981. PMC 145891. PMID 8668525.
- ^ “RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions”. Journal of Virology 76 (16): 8019–30. (August 2002). doi:10.1128/JVI.76.16.8019-8030.2002. PMC 155123. PMID 12134007.
- ^ a b c “Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process”. Journal of Molecular Biology 380 (5): 869–85. (July 2008). doi:10.1016/j.jmb.2008.05.043. PMID 18572193.
- ^ “Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1”. The Biochemical Journal 348 Pt 2 (2): 281–9. (June 2000). doi:10.1042/0264-6021:3480281. PMC 1221064. PMID 10816420.
- ^ “The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter”. Molecular and Cellular Biology 18 (12): 7147–56. (December 1998). doi:10.1128/mcb.18.12.7147. PMC 109296. PMID 9819401.
- ^ “NF-kappaB induced by IL-1beta inhibits elastin transcription and myofibroblast phenotype”. American Journal of Physiology. Cell Physiology 283 (1): C58-65. (July 2002). doi:10.1152/ajpcell.00314.2001. PMID 12055073.
- ^ “Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1”. Journal of Virology 68 (11): 7131–8. (November 1994). doi:10.1128/JVI.68.11.7131-7138.1994. PMC 237152. PMID 7933095.
- ^ “Identification of a critical Sp1 site within the endoglin promoter and its involvement in the transforming growth factor-beta stimulation”. The Journal of Biological Chemistry 276 (37): 34486–94. (September 2001). doi:10.1074/jbc.M011611200. PMID 11432852.
- ^ “Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells”. The Journal of Biological Chemistry 276 (10): 6983–92. (March 2001). doi:10.1074/jbc.M006442200. PMID 11114293.
- ^ “Sp1 and SF-1 interact and cooperate in the regulation of human steroidogenic acute regulatory protein gene expression”. Endocrinology 141 (8): 2895–903. (August 2000). doi:10.1210/en.141.8.2895. PMID 10919277.
- ^ “The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1”. Blood 100 (7): 2430–40. (October 2002). doi:10.1182/blood-2002-02-0568. PMID 12239153.
- ^ “Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53”. Molecular and Cellular Biology 18 (11): 6191–200. (November 1998). doi:10.1128/mcb.18.11.6191. PMC 109206. PMID 9774636.
[続きの解説]
「Sp1転写因子」の続きの解説一覧
- 1 Sp1転写因子とは
- 2 Sp1転写因子の概要
- 3 機能
- 4 阻害剤
- 5 関連文献
- 6 外部リンク
- Sp1転写因子のページへのリンク
