Eph受容体
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/10/04 05:14 UTC 版)
Eph受容体(Ephじゅようたい、英: Eph receptors、エリスロポエチン産生肝細胞受容体[erythropoietin-producing hepatocellular receptor]より)は、エフリンの結合に応答して活性化される受容体の一群である。Ephは受容体型チロシンキナーゼの最大のサブファミリーを構成する。Eph受容体と対応するエフリンリガンドはともに膜結合タンパク質であり、Eph受容体の活性化には直接的な細胞間相互作用が必要である。Eph/エフリンシグナル伝達は、軸索誘導[1]や組織境界の形成[2]、細胞遊走、分節化を含む、胚発生に重要な多くの過程を調節していることが示唆されている[3]。さらに近年、Eph/エフリンシグナル伝達は成体でも長期増強[4]や血管新生[5]、幹細胞の分化とがん化[6]を含むいくつかの過程の維持に重要な役割を果たしていることが同定された。
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- ^ a b “Mechanisms and functions of Eph and ephrin signalling”. Nat. Rev. Mol. Cell Biol. 3 (7): 475–86. (July 2002). doi:10.1038/nrm856. PMID 12094214.
- ^ “Regulation of angiogenesis by Eph-ephrin interactions”. Trends Cardiovasc. Med. 17 (5): 145–51. (July 2007). doi:10.1016/j.tcm.2007.03.003. PMID 17574121.
- ^ “Ephrins and Eph receptors in stem cells and cancer”. Curr. Opin. Cell Biol. 22 (5): 611–6. (October 2010). doi:10.1016/j.ceb.2010.08.005. PMID 20810264.
- ^ Eph Nomenclature Committee (August 1997). “Unified nomenclature for Eph family receptors and their ligands, the ephrins”. Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
- ^ “Eph/ephrin molecules--a hub for signaling and endocytosis”. Genes Dev. 24 (22): 2480–92. (November 2010). doi:10.1101/gad.1973910. PMC 2975924. PMID 21078817 .
- ^ Pasquale EB (October 1997). “The Eph family of receptors”. Curr. Opin. Cell Biol. 9 (5): 608–15. doi:10.1016/S0955-0674(97)80113-5. PMID 9330863.
- ^ “Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling”. Nat. Neurosci. 7 (5): 501–9. (May 2004). doi:10.1038/nn1237. PMID 15107857.
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- ^ “Multiple in vivo tyrosine phosphorylation sites in EphB receptors”. Biochemistry 38 (43): 14396–408. (October 1999). doi:10.1021/bi991628t. PMID 10572014.
- ^ “Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling”. Proc. Natl. Acad. Sci. U.S.A. 107 (19): 8830–5. (May 2010). doi:10.1073/pnas.0910644107. PMC 2889310. PMID 20410461 .
- ^ Xu, Q.; Malecka, K. L.; Fink, L.; Jordan, E. J.; Duffy, E.; Kolander, S.; Peterson, J. R.; Dunbrack, R. L. (1 December 2015). “Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases”. Science Signaling 8 (405): rs13. doi:10.1126/scisignal.aaa6711. PMC 4766099. PMID 26628682 .
- ^ Daar IO (February 2012). “Non-SH2/PDZ reverse signaling by ephrins”. Semin. Cell Dev. Biol. 23 (1): 65–74. doi:10.1016/j.semcdb.2011.10.012. PMC 3288889. PMID 22040914 .
- ^ a b c d “Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains”. Cell 121 (1): 127–39. (April 2005). doi:10.1016/j.cell.2005.01.020. PMID 15820684.
- ^ “Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells”. Science 326 (5959): 1502–9. (December 2009). doi:10.1126/science.1176615. PMID 20007894.
- ^ a b c d “Eph receptors and ephrins: effectors of morphogenesis”. Development 126 (10): 2033–44. (May 1999). PMID 10207129.
- ^ “Eph signaling is required for segmentation and differentiation of the somites”. Genes Dev. 12 (19): 3096–109. (October 1998). doi:10.1101/gad.12.19.3096. PMC 317186. PMID 9765210 .
- ^ a b “The ephrins and Eph receptors in neural development”. Annu. Rev. Neurosci. 21: 309–45. (1998). doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- ^ “Eph and ephrin signaling in the formation of topographic maps”. Semin. Cell Dev. Biol. 23 (1): 7–15. (February 2012). doi:10.1016/j.semcdb.2011.10.026. PMC 3288406. PMID 22044886 .
- ^ “Ephrin-B2 elicits differential growth cone collapse and axon retraction in retinal ganglion cells from distinct retinal regions”. Dev Neurobiol 70 (11): 781–94. (September 2010). doi:10.1002/dneu.20821. PMC 2930402. PMID 20629048 .
- ^ “Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map”. Cell 82 (3): 371–81. (August 1995). doi:10.1016/0092-8674(95)90426-3. hdl:2164/10927. PMID 7634327.
- ^ “Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system”. Proc. Natl. Acad. Sci. U.S.A. 93 (20): 11161–6. (October 1996). doi:10.1073/pnas.93.20.11161. PMC 38301. PMID 8855326 .
- ^ “Eph and ephrin signaling: lessons learned from spinal motor neurons”. Semin. Cell Dev. Biol. 23 (1): 83–91. (February 2012). doi:10.1016/j.semcdb.2011.10.016. PMID 22040916.
- ^ “Roles of Eph receptors and ephrins in neural crest pathfinding”. Cell Tissue Res. 290 (2): 265–74. (November 1997). doi:10.1007/s004410050931. PMID 9321688.
- ^ “The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans”. Cell 92 (5): 633–43. (Mar 1998). doi:10.1016/s0092-8674(00)81131-9. PMID 9506518.
- ^ “The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans”. Cell 99 (7): 781–90. (Dec 1999). doi:10.1016/s0092-8674(00)81675-x. PMID 10619431.
- ^ a b c d e “The ephrins and Eph receptors in angiogenesis”. Cytokine Growth Factor Rev. 13 (1): 75–85. (February 2002). doi:10.1016/S1359-6101(01)00031-4. PMID 11750881.
- ^ “Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4”. Cell 93 (5): 741–53. (May 1998). doi:10.1016/S0092-8674(00)81436-1. PMID 9630219.
- ^ “Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis”. Genes Dev. 13 (3): 295–306. (February 1999). doi:10.1101/gad.13.3.295. PMC 316426. PMID 9990854 .
- ^ “Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds”. Development 122 (4): 1147–55. (April 1996). PMID 8620841.
- ^ “Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines”. Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1611–5. (March 1992). doi:10.1073/pnas.89.5.1611. PMC 48502. PMID 1311845 .
- ^ “Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors”. Cancer Res. 54 (14): 3645–50. (July 1994). PMID 8033077.
- ^ “Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis”. Int. J. Cancer 60 (1): 129–36. (January 1995). doi:10.1002/ijc.2910600119. PMID 7814145.
- ^ a b c “The role of ephrins and Eph receptors in cancer”. Cytokine Growth Factor Rev. 15 (6): 419–33. (December 2004). doi:10.1016/j.cytogfr.2004.09.002. PMID 15561600.
- ^ “'Eph'ective signaling: forward, reverse and crosstalk”. J. Cell Sci. 116 (Pt 14): 2823–32. (July 2003). doi:10.1242/jcs.00625. PMID 12808016.
- ^ “Signals from Eph and ephrin proteins: a developmental tool kit”. Sci. STKE 2001 (112): re20. (December 2001). doi:10.1126/stke.2001.112.re20. PMID 11741094.
- 1 Eph受容体とは
- 2 Eph受容体の概要
- 3 機能
- 4 発見と歴史
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