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ERCC1

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/01/28 05:16 UTC 版)

ERCC1(excision repair cross-complementation group 1)は、ヒトではERCC1遺伝子にコードされるタンパク質である[5]。ERCC1はERCC4英語版とともにERCC1-XPF複合体を形成し、DNA修復DNA組換えに関与する[6][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000012061 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003549 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
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  7. ^ Entrez Gene: ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4”. 2023年1月12日閲覧。
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  14. ^ “Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair”. Nucleic Acids Research 29 (4): 872–9. (February 2001). doi:10.1093/nar/29.4.872. PMC 29621. PMID 11160918. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29621/. 
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  17. ^ a b “DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy”. Nucleic Acids Research 40 (20): 9990–10004. (November 2012). doi:10.1093/nar/gks818. PMC 3488251. PMID 22941649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488251/. 
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  20. ^ “The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells”. Nucleic Acids Research 36 (1): 1–9. (January 2008). doi:10.1093/nar/gkm888. PMC 2248766. PMID 17962301. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248766/. 
  21. ^ “Recombination-dependent deletion formation in mammalian cells deficient in the nucleotide excision repair gene ERCC1”. Proceedings of the National Academy of Sciences of the United States of America 94 (24): 13122–7. (November 1997). Bibcode1997PNAS...9413122S. doi:10.1073/pnas.94.24.13122. PMC 24273. PMID 9371810. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24273/. 
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  23. ^ “Mammalian nucleotide excision repair proteins and interstrand crosslink repair”. Environmental and Molecular Mutagenesis 51 (6): 520–6. (July 2010). doi:10.1002/em.20569. PMC 3017513. PMID 20658645. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017513/. 
  24. ^ “XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4”. Molecular Cell 54 (3): 460–71. (May 2014). doi:10.1016/j.molcel.2014.03.015. PMC 5067070. PMID 24726325. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067070/. 
  25. ^ “Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease”. The Journal of Biological Chemistry 275 (34): 26632–6. (August 2000). doi:10.1074/jbc.C000337200. PMID 10882712. 
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  29. ^ a b “The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex”. The Journal of Biological Chemistry 290 (33): 20541–55. (August 2015). doi:10.1074/jbc.M114.635169. PMC 4536458. PMID 26085086. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536458/. 
  30. ^ “Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia”. American Journal of Human Genetics 92 (5): 807–19. (May 2013). doi:10.1016/j.ajhg.2013.04.007. PMC 3644632. PMID 23623389. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644632/. 
  31. ^ “Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer”. Annals of Oncology 18 (3): 504–9. (March 2007). doi:10.1093/annonc/mdl430. PMID 17322540. 
  32. ^ “Gene expression of ERCC1 as a novel prognostic marker in advanced bladder cancer patients receiving cisplatin-based chemotherapy”. Annals of Oncology 18 (3): 522–8. (March 2007). doi:10.1093/annonc/mdl435. PMID 17229776. 
  33. ^ “DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy”. The New England Journal of Medicine 355 (10): 983–91. (September 2006). doi:10.1056/NEJMoa060570. PMID 16957145. 
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  35. ^ a b “Precision treatment in colorectal cancer: Now and the future”. JGH Open 3 (5): 361–369. (October 2019). doi:10.1002/jgh3.12153. PMC 6788378. PMID 31633039. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788378/. 
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  41. ^ a b “Analysis of aberrant methylation in DNA repair genes during malignant transformation of human bronchial epithelial cells induced by cadmium”. Toxicological Sciences 125 (2): 412–7. (February 2012). doi:10.1093/toxsci/kfr320. PMID 22112500. 
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  43. ^ “Regulation of DNA repair gene expression in human cancer cell lines”. Journal of Cellular Biochemistry 97 (5): 1121–36. (April 2006). doi:10.1002/jcb.20711. PMID 16315315. 
  44. ^ “HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression”. Retrovirology 6: 18. (February 2009). doi:10.1186/1742-4690-6-18. PMC 2654423. PMID 19220914. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654423/. 
  45. ^ “miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer”. PLOS ONE 8 (1): e54398. (2013). Bibcode2013PLoSO...854398V. doi:10.1371/journal.pone.0054398. PMC 3547033. PMID 23342147. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547033/. 
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  48. ^ “High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity”. Nucleic Acids Research 31 (23): 6841–51. (December 2003). doi:10.1093/nar/gkg884. PMC 290254. PMID 14627817. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC290254/. 
  49. ^ a b c “Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice”. Nature 537 (7620): 427–431. (September 2016). Bibcode2016Natur.537..427V. doi:10.1038/nature19329. PMC 5161687. PMID 27556946. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161687/. 
  50. ^ “Understanding nucleotide excision repair and its roles in cancer and ageing”. Nature Reviews. Molecular Cell Biology 15 (7): 465–81. (July 2014). doi:10.1038/nrm3822. PMID 24954209. 
  51. ^ “DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse”. Development 130 (2): 369–78. (January 2003). doi:10.1242/dev.00221. PMID 12466203. 


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