コネクシン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2020/04/08 05:58 UTC 版)
コネクシン (Connexin) は脊椎動物に見られる一群の膜貫通タンパク質で、ギャップ結合を形成する。無脊椎動物のギャップ結合を形成するイネキシンとは構造的に関連がない[1]。ギャップ結合は半チャネル（コネクソン）の対から構成され、半チャネルは6分子のコネクシンから構成される。心筋の協調した分極や胚の適切な発達、微小血管系での伝導反応等、多くの生理過程に必須であり、コネクシンをコードする遺伝子の突然変異は、機能や発達の異常に繋がる。
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- ^ Beyer, Eric C.; Berthound, Viviana M. (16 January 2009). Connexins: A Guide (1st ed.). Springer-Verlag Gmbh. pp. 387–417. ISBN 1-934115-46-0.
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- ^ del Castillo I et al. (January 24, 2002). “A deletion involving the connexin 30 gene in nonsyndromic hearing impairment”. N Engl J Med 346 (4): 343–9. doi:10.1056/NEJMoa012052. PMID 11807148.
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- ^ Li X, Lynn BD, Olson C, et al. (September 2002). “Connexin29 expression, immunocytochemistry and freeze-fracture replica immunogold labelling (FRIL) in sciatic nerve”. Eur. J. Neurosci. 16 (5): 795–806. doi:10.1046/j.1460-9568.2002.02149.x. PMC: 1803218. PMID 12372015.
[続きの解説]
「コネクシン」の続きの解説一覧
- 1 コネクシンとは
- 2 コネクシンの概要
- 3 ヒトのコネクシンの一覧
- 4 外部リンク
- コネクシンのページへのリンク
