シグナル伝達兼転写活性化因子3
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/12/22 12:58 UTC 版)
シグナル伝達兼転写活性化因子3（signal transducer and activator of transcription 3、STAT3）は、ヒトではSTAT3遺伝子にコードされる転写因子である[5]。STATタンパク質ファミリーのメンバーである。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000168610 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004040 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ “Structure, function, and regulation of STAT proteins”. Molecular BioSystems 2 (11): 536–50. (November 2006). doi:10.1039/B606246F. PMID 17216035..
- ^ “Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells”. Molecular and Cellular Biology 24 (21): 9390–400. (November 2004). doi:10.1128/MCB.24.21.9390-9400.2004. PMC 522220. PMID 15485908. 15485908.
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- ^ “STAT3 regulates cytokine-mediated generation of inflammatory helper T cells”. The Journal of Biological Chemistry 282 (13): 9358–63. (March 2007). doi:10.1074/jbc.C600321200. PMID 17277312.
- ^ “T-cell STAT3 is required for the maintenance of humoral immunity to LCMV”. European Journal of Immunology 45 (2): 418–27. (February 2015). doi:10.1002/eji.201445060. PMC 4383653. PMID 25393615.
- ^ Coppo, Roberto; Orso, Francesca; Virga, Federico; Dalmasso, Alberto; Baruffaldi, Desirée; Nie, Lei; Clapero, Fabiana; Dettori, Daniela et al. (2021-07-10). “ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3”. Cancer Letters 510: 13–23. doi:10.1016/j.canlet.2021.04.005. ISSN 1872-7980. PMID 33862151.
- ^ “STAT3 signaling and the hyper-IgE syndrome”. The New England Journal of Medicine 357 (16): 1655–8. (October 2007). doi:10.1056/NEJMe078197. PMID 17881746.
- ^ “Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations”. Blood 125 (4): 591–9. (January 2015). doi:10.1182/blood-2014-09-602763. PMC 4304103. PMID 25359994.
- ^ a b “Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs”. Current Cancer Drug Targets 6 (2): 107–21. (March 2006). doi:10.2174/156800906776056491. PMID 16529541.
- ^ “Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor”. Cancer Research 66 (6): 3162–8. (March 2006). doi:10.1158/0008-5472.CAN-05-3757. PMID 16540667.
- ^ “Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions”. Molecular Cancer 5 (1): 15. (April 2006). doi:10.1186/1476-4598-5-15. PMC 1502137. PMID 16603078.
- ^ “Activation of STAT3 is a marker of poor prognosis in human colorectal cancer”. Oncology Reports 15 (6): 1445–51. (June 2006). doi:10.3892/or.15.6.1445. PMID 16685378.
- ^ “Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway”. Genes & Development 22 (4): 449–62. (February 2008). doi:10.1101/gad.1606508. PMC 2238667. PMID 18258752.
- ^ “Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability”. The Journal of Biological Chemistry. 22 287 (22): 18182–9. (May 2012). doi:10.1074/jbc.M111.328831. PMC 3365759. PMID 22496368.
- ^ “Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice”. Gastroenterology 138 (3): 1003–11.e1–5. (March 2010). doi:10.1053/j.gastro.2009.11.049. PMID 19962983.
- ^ Vlahopoulos, SA (August 2017). “Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode.”. Cancer Biology & Medicine 14 (3): 254–270. doi:10.20892/j.issn.2095-3941.2017.0029. PMC 5570602. PMID 28884042.
- ^ a b “Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways”. The Journal of Biological Chemistry 277 (9): 7076–85. (March 2002). doi:10.1074/jbc.M108255200. PMID 11751884.
- ^ “Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells”. Biochemical and Biophysical Research Communications 283 (1): 179–87. (April 2001). doi:10.1006/bbrc.2001.4758. PMID 11322786.
- ^ “A Stat3-interacting protein (StIP1) regulates cytokine signal transduction”. Proceedings of the National Academy of Sciences of the United States of America 97 (18): 10120–5. (August 2000). Bibcode: 2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
- ^ “Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300”. Science 284 (5413): 479–82. (April 1999). doi:10.1126/science.284.5413.479. PMID 10205054.
- ^ a b “Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells”. Molecular and Cellular Biology 24 (21): 9390–400. (November 2004). doi:10.1128/MCB.24.21.9390-9400.2004. PMC 522220. PMID 15485908.
- ^ “ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases”. The Journal of Biological Chemistry 274 (24): 17209–18. (June 1999). doi:10.1074/jbc.274.24.17209. PMID 10358079.
- ^ “STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination”. Experimental & Molecular Medicine 40 (5): 479–85. (October 2008). doi:10.3858/emm.2008.40.5.479. PMC 2679355. PMID 18985005.
- ^ a b “Constitutive activation of STAT transcription factors in acute myelogenous leukemia”. European Journal of Haematology 67 (2): 63–71. (August 2001). doi:10.1034/j.1600-0609.2001.t01-1-00385.x. PMID 11722592.
- ^ “Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation”. Molecular and Cellular Biology 19 (10): 7138–46. (October 1999). doi:10.1128/MCB.19.10.7138. PMC 84707. PMID 10490649.
- ^ “Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway”. Cellular Immunology 211 (1): 30–6. (July 2001). doi:10.1006/cimm.2001.1815. PMID 11585385.
- ^ “Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR”. Current Biology 10 (1): 47–50. (January 2000). doi:10.1016/S0960-9822(99)00268-7. PMID 10660304.
- ^ “Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)”. The Journal of Biological Chemistry 280 (2): 1037–43. (January 2005). doi:10.1074/jbc.M405204200. PMID 15522880.
- ^ “Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts”. The Journal of Biological Chemistry 278 (45): 44178–87. (November 2003). doi:10.1074/jbc.M304884200. PMID 12947115.
- ^ “The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3”. Proceedings of the National Academy of Sciences of the United States of America 100 (16): 9342–7. (August 2003). Bibcode: 2003PNAS..100.9342Z. doi:10.1073/pnas.1633516100. PMC 170920. PMID 12867595.
- ^ a b “Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB”. The Biochemical Journal 367 (Pt 1): 97–105. (October 2002). doi:10.1042/BJ20020588. PMC 1222853. PMID 12057007.
- ^ “STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene”. Genes & Development 17 (20): 2564–77. (October 2003). doi:10.1101/gad.1135003. PMC 218150. PMID 14522952.
- ^ “STAT3 acts as a co-activator of glucocorticoid receptor signaling”. The Journal of Biological Chemistry 272 (49): 30607–10. (December 1997). doi:10.1074/jbc.272.49.30607. PMID 9388192.
- ^ “Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a”. The Journal of Biological Chemistry 277 (10): 8004–11. (March 2002). doi:10.1074/jbc.M111486200. PMID 11773079.
- ^ “Opposing effects of PML and PML/RAR alpha on STAT3 activity”. Blood 101 (9): 3668–73. (May 2003). doi:10.1182/blood-2002-08-2474. PMID 12506013.
- ^ “Regulation of STAT3 by direct binding to the Rac1 GTPase”. Science 290 (5489): 144–7. (October 2000). Bibcode: 2000Sci...290..144S. doi:10.1126/science.290.5489.144. PMID 11021801.
- ^ “Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation”. Molecular Endocrinology 17 (6): 1155–66. (June 2003). doi:10.1210/me.2002-0401. PMID 12637586.
- ^ “MEN2A-RET-induced cellular transformation by activation of STAT3”. Oncogene 20 (38): 5350–8. (August 2001). doi:10.1038/sj.onc.1204715. PMID 11536047.
- ^ “Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its transcriptional activity”. Cell Biology International 24 (7): 467–73. (2000). doi:10.1006/cbir.2000.0525. PMID 10875894.
- ^ “Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin”. Biochemical and Biophysical Research Communications 288 (1): 252–7. (October 2001). doi:10.1006/bbrc.2001.5759. PMID 11594781.
- ^ “Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation”. The Journal of Biological Chemistry 277 (34): 30716–23. (August 2002). doi:10.1074/jbc.M202823200. PMID 12070153.
- ^ “Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1”. Nature Communications 8: 15289. (May 2017). Bibcode: 2017NatCo...815289M. doi:10.1038/ncomms15289. PMC 5424153. PMID 28474672.
- ^ “Activation and association of Stat3 with Src in v-Src-transformed cell lines”. Molecular and Cellular Biology 16 (4): 1595–603. (April 1996). doi:10.1128/MCB.16.4.1595. PMC 231145. PMID 8657134.
- ^ “Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein”. Journal of Virology 78 (12): 6489–97. (June 2004). doi:10.1128/JVI.78.12.6489-6497.2004. PMC 416526. PMID 15163742.
- ^ “STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3”. Proceedings of the National Academy of Sciences of the United States of America 102 (23): 8150–5. (June 2005). Bibcode: 2005PNAS..102.8150L. doi:10.1073/pnas.0501643102. PMC 1149424. PMID 15919823.
- ^ “Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway”. ACS Medicinal Chemistry Letters 1 (9): 454–9. (2010). doi:10.1021/ml100146z. PMC 4007964. PMID 24900231.
[続きの解説]
「シグナル伝達兼転写活性化因子3」の続きの解説一覧
- 1 シグナル伝達兼転写活性化因子3とは
- 2 シグナル伝達兼転写活性化因子3の概要
- 3 機能
- 4 臨床的意義
- 5 関連文献
- 6 外部リンク
- シグナル伝達兼転写活性化因子3のページへのリンク
