RAD50
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/08/19 04:22 UTC 版)
RAD50は、ヒトではRAD50遺伝子にコードされるタンパク質である[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000113522 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020380 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b “Entrez Gene: RAD50 RAD50 homolog (S. cerevisiae)”. 2022年7月5日閲覧。
- ^ “RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?”. Chromosome Res. 17 (2): 277–88. (2009). doi:10.1007/s10577-008-9018-6. PMC 4494100. PMID 19308707.
- ^ “The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair”. Nature 418 (6897): 562–6. (August 2002). Bibcode: 2002Natur.418..562H. doi:10.1038/nature00922. PMID 12152085.
- ^ “Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA”. Nature 437 (7057): 440–3. (September 2005). Bibcode: 2005Natur.437..440M. doi:10.1038/nature03927. PMID 16163361.
- ^ a b c “BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures”. Genes Dev. 14 (8): 927–39. (2000). doi:10.1101/gad.14.8.927. PMC 316544. PMID 10783165.
- ^ a b “Redistribution of BRCA1 among four different protein complexes following replication blockage”. J. Biol. Chem. 276 (42): 38549–54. (2001). doi:10.1074/jbc.M105227200. PMID 11504724.
- ^ “Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response”. Science 285 (5428): 747–50. (1999). doi:10.1126/science.285.5428.747. PMID 10426999.
- ^ “Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair”. Mol. Cell. Biol. 16 (9): 4832–41. (1996). doi:10.1128/MCB.16.9.4832. PMC 231485. PMID 8756642.
- ^ a b “Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95”. J. Biol. Chem. 273 (34): 21447–50. (1998). doi:10.1074/jbc.273.34.21447. PMID 9705271.
- ^ “Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis”. Nat. Genet. 23 (2): 194–8. (1999). doi:10.1038/13821. PMID 10508516.
- ^ “Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation”. J. Biol. Chem. 278 (24): 21944–51. (2003). doi:10.1074/jbc.M211689200. PMID 12679336.
- ^ “Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization”. Mol. Cell. Biol. 21 (6): 2184–91. (2001). doi:10.1128/MCB.21.6.2184-2191.2001. PMC 86852. PMID 11238951.
- ^ “RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control”. J. Biol. Chem. 276 (9): 6105–11. (2001). doi:10.1074/jbc.M008893200. PMID 11096100.
- ^ a b “The human Rap1 protein complex and modulation of telomere length”. J. Biol. Chem. 279 (27): 28585–91. (2004). doi:10.1074/jbc.M312913200. PMID 15100233.
- ^ “Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres”. Nat. Genet. 25 (3): 347–52. (2000). doi:10.1038/77139. PMID 10888888.
- ^ White MF (January 2011). “Homologous recombination in the archaea: the means justify the ends”. Biochem. Soc. Trans. 39 (1): 15–9. doi:10.1042/BST0390015. PMID 21265740.
- ^ “The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius”. BMC Mol. Biol. 9: 25. (2008). doi:10.1186/1471-2199-9-25. PMC 2288612. PMID 18294364.
- ^ “Human RAD50 deficiency in a Nijmegen Breakage Syndrome-like disorder”. Am. J. Hum. Genet. 84 (5): 605–16. (2009). doi:10.1016/j.ajhg.2009.04.010. PMC 2681000. PMID 19409520.
- ^ “Human RAD50 deficiency: Confirmation of a distinctive phenotype”. Am. J. Med. Genet. 182 (6): 1378–86. (2020). doi:10.1002/ajmg.a.61570. PMC 7318339. PMID 32212377.
- ^ “A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans”. Cell Rep. 33 (13): 108559. (2020). doi:10.1016/j.celrep.2020.108559. PMC 7788285. PMID 33378670.
[続きの解説]
「RAD50」の続きの解説一覧
- 1 RAD50とは
- 2 RAD50の概要
- 3 機能
- 4 疾患
- RAD50のページへのリンク
