CCL2
(MCP-1 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/03 09:34 UTC 版)
CCL2（C-C motif chemokine ligand 2）は、CCケモカインファミリーに属するサイトカインである。MCP-1（monocyte chemoattractant protein 1）、SCYA2（small inducible cytokine A2）といった名称でも知られる。CCL2は細胞の力学的性質を緊密に調節し[5]、組織損傷や感染による炎症部位へ単球、メモリーT細胞、樹状細胞をリクルートする[6][7]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000108691 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035352 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Single-cell analysis reveals chemokine-mediated differential regulation of monocyte mechanics”. iScience 25 (1): 103555. (January 2022). Bibcode: 2022iSci...25j3555E. doi:10.1016/j.isci.2021.103555. PMC 8693412. PMID 34988399.
- ^ “Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant”. Proceedings of the National Academy of Sciences of the United States of America 91 (9): 3652–6. (April 1994). Bibcode: 1994PNAS...91.3652C. doi:10.1073/pnas.91.9.3652. PMC 43639. PMID 8170963.
- ^ “Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro”. Journal of Leukocyte Biology 60 (3): 365–71. (September 1996). doi:10.1002/jlb.60.3.365. PMID 8830793.
- ^ “Localization of monocyte chemotactic protein-1 gene (SCYA2) to human chromosome 17q11.2-q21.1”. Genomics 9 (1): 200–3. (January 1991). doi:10.1016/0888-7543(91)90239-B. PMID 2004761.
- ^ “Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE”. FEBS Letters 244 (2): 487–93. (February 1989). doi:10.1016/0014-5793(89)80590-3. PMID 2465924.
- ^ “Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)”. Biochemical and Biophysical Research Communications 159 (1): 249–55. (February 1989). doi:10.1016/0006-291X(89)92430-3. PMID 2923622.
- ^ “CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study”. Circulation 112 (8): 1113–20. (August 2005). doi:10.1161/CIRCULATIONAHA.105.543579. PMID 16116069.
- ^ “Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination”. Genes and Immunity 8 (8): 684–90. (December 2007). doi:10.1038/sj.gene.6364434. PMID 17917677.
- ^ Yoshimura, T (April 2018). “The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?”. Cellular & Molecular Immunology 15 (4): 335–345. doi:10.1038/cmi.2017.135. PMC 6052833. PMID 29375123.
- ^ “CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases”. Cancer and Metastasis Reviews 25 (4): 611–9. (December 2006). doi:10.1007/s10555-006-9027-x. PMID 17160712.
- ^ “Monocyte chemotactic protein-1 provokes mast cell aggregation and [3H5HT release”]. Immunology 86 (3): 434–40. (November 1995). PMC 1383948. PMID 8550082.
- ^ “Monocyte chemotactic protein 1 is a potent activator of human basophils”. The Journal of Experimental Medicine 175 (5): 1271–5. (May 1992). doi:10.1084/jem.175.5.1271. PMC 2119199. PMID 1569397.
- ^ “Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx”. Blood 112 (8): 3455–64. (October 2008). doi:10.1182/blood-2007-12-129080. PMID 18660381.
- ^ “MCP-1 is induced by receptor activator of nuclear factor-κB ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation”. The Journal of Biological Chemistry 280 (16): 16163–9. (April 2005). doi:10.1074/jbc.M412713200. PMID 15722361.
- ^ “Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides”. The Journal of Comparative Neurology 489 (3): 275–92. (August 2005). doi:10.1002/cne.20598. PMID 16025454.
- ^ “Recent developments in CCR2 antagonists”. Expert Opinion on Therapeutic Patents 19 (3): 295–303. (March 2009). doi:10.1517/13543770902755129. PMID 19441905.
- ^ “RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis”. The Journal of Experimental Medicine 185 (7): 1371–80. (April 1997). doi:10.1084/jem.185.7.1371. PMC 2196251. PMID 9104823.
- ^ “Chemokines and disease”. Nature Immunology 2 (2): 108–15. (February 2001). doi:10.1038/84209. PMID 11175802.
- ^ “Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus”. Journal of Neuroinflammation 6: 40. (December 2009). doi:10.1186/1742-2094-6-40. PMC 2804573. PMID 20034406.
- ^ “The emerging role for chemokines in epilepsy”. Journal of Neuroimmunology 224 (1–2): 22–7. (July 2010). doi:10.1016/j.jneuroim.2010.05.016. PMID 20542576.
- ^ “Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat”. Journal of Neuroimmunology 56 (2): 127–34. (February 1995). doi:10.1016/0165-5728(94)00138-e. PMID 7860708.
- ^ “Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease”. CNS & Neurological Disorders Drug Targets 9 (2): 168–73. (April 2010). doi:10.2174/187152710791011982. PMC 3684802. PMID 20205643.
- ^ “Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis”. FASEB Journal 7 (6): 592–600. (April 1993). doi:10.1096/fasebj.7.6.8472896. PMID 8472896.
- ^ “Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice”. Journal of Cerebral Blood Flow and Metabolism 30 (4): 769–82. (April 2010). doi:10.1038/jcbfm.2009.262. PMC 2949175. PMID 20029451.
- ^ “Methylation status of CpG sites in the MCP-1 promoter is correlated to serum MCP-1 in Type 2 diabetes”. Journal of Endocrinological Investigation 35 (6): 585–9. (June 2012). doi:10.3275/7981. PMID 21975431.
- ^ Fadini, Gian Paolo, ed (May 2011). “MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2”. PLOS ONE 6 (5): e19559. Bibcode: 2011PLoSO...619559C. doi:10.1371/journal.pone.0019559. PMC 3092759. PMID 21589925.
- ^ “Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle”. Endocrinology 147 (5): 2458–67. (May 2006). doi:10.1210/en.2005-0969. PMID 16439461.
- ^ “Induction of brain natriuretic peptide and monocyte chemotactic protein-1 gene expression by oxidized low-density lipoprotein: relevance to ischemic heart failure”. American Journal of Physiology. Cell Physiology 302 (1): C165-77. (January 2012). doi:10.1152/ajpcell.00116.2011. PMID 21900689.
- ^ “Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)”. Experimental Gerontology 45 (12): 950–6. (December 2010). doi:10.1016/j.exger.2010.08.016. PMID 20817086.
[続きの解説]
- MCP-1のページへのリンク
