CTCF
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/07/03 09:36 UTC 版)
転写抑制因子CTCF（別名: CCCTC結合因子（CCCTC-binding factor）、11-zinc finger protein）は、ヒトではCTCF遺伝子にコードされる転写因子である[5][6]。CTCFは、転写の調節、インスレーター活性、V(D)J組換え、クロマチン構造の調節など、多くの細胞過程に関与する[7]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102974 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005698 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b “An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes”. Mol. Cell. Biol. 16 (6): 2802–13. (June 1996). PMC 231272. PMID 8649389.
- ^ “CTCF physically links cohesin to chromatin”. Proc. Natl. Acad. Sci. U.S.A. 105 (24): 8309–14. (June 2008). doi:10.1073/pnas.0801273105. PMC 2448833. PMID 18550811.
- ^ a b c “CTCF: master weaver of the genome”. Cell 137 (7): 1194–211. (June 2009). doi:10.1016/j.cell.2009.06.001. PMC 3040116. PMID 19563753.
- ^ “A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene”. Oncogene 5 (12): 1743–53. (December 1990). PMID 2284094.
- ^ a b “Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions”. Nature 453 (7197): 948–51. (June 2008). doi:10.1038/nature06947. PMID 18463634.
- ^ “CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease”. Trends Genet. 17 (9): 520–7. (2001). doi:10.1016/S0168-9525(01)02366-6. PMID 11525835.
- ^ “The many roles of the transcriptional regulator CTCF”. Biochem. Cell Biol. 81 (3): 161–7. (2003). doi:10.1139/o03-052. PMID 12897849.
- ^ a b c “Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains”. Genome Res. 19 (1): 24–32. (2009). doi:10.1101/gr.082800.108. PMC 2612964. PMID 19056695.
- ^ a b “CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species”. Mol. Cell 13 (2): 291–8. (January 2004). doi:10.1016/S1097-2765(04)00029-2. PMID 14759373.
- ^ “CTCF-dependent enhancer-blocking by alternative chromatin loop formation”. Proc. Natl. Acad. Sci. U.S.A. 105 (51): 20398–403. (December 2008). doi:10.1073/pnas.0808506106. PMC 2629272. PMID 19074263.
- ^ “Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation”. J. Biol. Chem. 287 (37): 30906–13. (September 2012). doi:10.1074/jbc.R111.324962. PMC 3438923. PMID 22952237.
- ^ “CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing”. Nature 479 (7371): 74–9. (November 2011). doi:10.1038/nature10442. PMID 21964334.
- ^ a b “Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome”. Cell 128 (6): 1231–45. (March 2007). doi:10.1016/j.cell.2006.12.048. PMC 2572726. PMID 17382889.
- ^ a b “Methylation loss at H19 imprinted gene correlates with methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples from infertile males”. Epigenetics 9 (9): 990–7. (September 2013). doi:10.4161/epi.25798. PMC 3883776. PMID 23975186.
- ^ “Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene”. Nature 405 (6785): 482–5. (May 2000). doi:10.1038/35013100. PMID 10839546.
- ^ “Widespread plasticity in CTCF occupancy linked to DNA methylation”. Genome Res. 22 (9): 1680–8. (September 2012). doi:10.1101/gr.136101.111. PMC 3431485. PMID 22955980.
- ^ “CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators”. Nucleic Acids Res. 36 (Database issue): D83–7. (January 2008). doi:10.1093/nar/gkm875. PMC 2238977. PMID 17981843.
- ^ “Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites”. Proc. Natl. Acad. Sci. U.S.A. 104 (17): 7145–50. (2007). doi:10.1073/pnas.0701811104. PMC 1852749. PMID 17442748.
- ^ “The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome”. PLOS Genetics 4 (7): e1000138. (2008). doi:10.1371/journal.pgen.1000138. PMC 2453330. PMID 18654629.
- ^ “Genome-wide nucleosome positioning during embryonic stem cell development”. Nat Struct Mol Biol 19 (11): 1185–92. (2012). doi:10.1038/nsmb.2419. PMID 23085715.
- ^ “Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF”. J. Biol. Chem. 275 (38): 29915–21. (September 2000). doi:10.1074/jbc.M001538200. PMID 10906122.
- ^ “Mediator and cohesin connect gene expression and chromatin architecture”. Nature 467 (7314): 430–5. (September 2010). doi:10.1038/nature09380. PMC 2953795. PMID 20720539.
[続きの解説]
「CTCF」の続きの解説一覧
- 1 CTCFとは
- 2 CTCFの概要
- 3 発見
- 4 タンパク質間相互作用
- CTCFのページへのリンク
