CIP/KIP
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/10/31 03:52 UTC 版)
CIP/KIP（CDK interacting protein/Kinase inhibitory protein）ファミリーは、哺乳類の細胞周期の調節に関与するサイクリン依存性キナーゼ阻害因子（CKI）の2つのファミリーのうちの1つである（もう1つはINK4）[1][2]。CIP/KIPファミリーは、p21CIP1/WAF1[3][4]、 p27KIP1[5]、p57KIP2[6][7]の3つのタンパク質から構成される。これらのタンパク質はN末端ドメインの配列に相同性が存在し、サイクリンとサイクリン依存性キナーゼ（CDK）の双方に結合する。その活性は主にG1/S期CDKとS期CDKへの結合と阻害であるが、G1期CDKであるCDK4とCDK6の活性化にも重要な役割を果たすことが示されている[8][9]。さらに、CIP/KIPファミリーのメンバーは、転写の調節、アポトーシス、細胞骨格などCDK非依存的な多くの役割も持つことが示されている[10][11][12][13]。
- ^ a b Morgan, David O. (2007). The Cell Cycle: Principles of Control (1st ed.). London: New Science Press. ISBN 978-0-87893-508-6
- ^ a b c “CDK inhibitors: positive and negative regulators of G1-phase progression”. Genes & Development 13 (12): 1501–1512. (1999). doi:10.1101/gad.13.12.1501. PMID 10385618.
- ^ “Inhibition of CDK 2 activity in vivo by an associated 20K regulatory subunit”. Nature 366 (6456): 707–710. (1993). Bibcode: 1993Natur.366..707G. doi:10.1038/366707a0. PMID 8259216.
- ^ “p21 is a universal inhibitor of cyclin kinases”. Nature 366 (6456): 701–704. (1993). Bibcode: 1993Natur.366..701X. doi:10.1038/366701a0. PMID 8259214.
- ^ “p27, a novel inhibitor of G1 cyclin/cdk protein kinase activity, is related to p21”. Cell 78 (1): 67–74. (1994). doi:10.1016/0092-8674(94)90573-8. PMID 8033213.
- ^ “p57kip2, a structureally distinct member of the p21 cip1 cdk inhibitor family, is a candidate tumor suppressor gene”. Genes & Development 9 (6): 650–662. (1995). doi:10.1101/gad.9.6.650. PMID 7729684.
- ^ “Cloning of p57kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution”. Genes & Development 9 (6): 639–649. (1995). doi:10.1101/gad.9.6.639. PMID 7729683.
- ^ a b Soos, T. J.; Kiyokawa, H.; Yan, J. S.; Rubin, M. S.; Giordano, A.; DeBlasio, A.; Bottega, S.; Wong, B. et al. (1996-02). “Formation of p27-CDK complexes during the human mitotic cell cycle”. Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research 7 (2): 135–146. ISSN 1044-9523. PMID 8822197.
- ^ a b c “New functional activities for the p21 family of CDK inhibitors”. Genes & Development 11 (7): 847–862. (1997). doi:10.1101/gad.11.7.847. PMID 9106657.
- ^ “New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment?”. Trends in Cell Biology 13 (2): 65–70. (2003). doi:10.1016/S0962-8924(02)00043-0. PMID 12559756.
- ^ “Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration”. Nature Methods 4 (12): 1449–1452. (1998). doi:10.1038/4042. PMID 9846587.
- ^ a b c “p27Kip1 modulates cell migration through the regulation of RhoA activation”. Genes & Development 18 (8): 851–855. (2004). doi:10.1101/gad.1185504. PMC 395846. PMID 15078817.
- ^ “Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice.”. PNAS 94 (26): 14590–14595. (1997). Bibcode: 1997PNAS...9414590W. doi:10.1073/pnas.94.26.14590. PMC 25064. PMID 9405657.
- ^ “Crystal structure of the p27Kip1 cyclin-dependent kinase inhibitor bound to the cyclin A-cdk2 complex.”. Nature 382 (6589): 325–331. (1996). Bibcode: 1996Natur.382..325R. doi:10.1038/382325a0. PMID 8684460.
- ^ “The p21Cip1 and p27Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts”. EMBO Journal 18 (6): 1571–1583. (1999). doi:10.1093/emboj/18.6.1571. PMC 1171245. PMID 10075928.
- ^ “Requirement of cyclin E-cdk2 inhibition in p16INK4a-mediated growth suppression”. Molecular and Cellular Biology 18 (9): 5284–5290. (1998). doi:10.1128/MCB.18.9.5284. PMC 109114. PMID 9710613.
- ^ “Cleavage of p21Cip?Waf1 and P27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade”. Molecular Cell 1 (4): 553–563. (1998). doi:10.1016/S1097-2765(00)80055-6. PMID 9660939.
- ^ “Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.”. Genes & Development 11 (8): 973–983. (1997). doi:10.1101/gad.11.8.973. PMID 9136926.
- ^ “p57Kip2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein kinase.”. Journal of Biological Chemistry 278 (48): 1158–1164. (2003). doi:10.1074/jbc.M309421200. PMID 12963725.
- ^ “P27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex”. Genes & Development 20 (11): 1511–1524. (2006). doi:10.1101/gad.377106. PMC 1475763. PMID 16705040.
- ^ “Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions.”. Molecular and Cellular Biology 23 (1): 216–228. (2003). doi:10.1128/MCB.23.1.216-228.2003. PMC 140659. PMID 12482975.
- ^ “Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer”. Nature Medicine 3 (2): 227–230. (1997). doi:10.1038/nm0297-227. PMID 9018244.
- ^ “Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas”. Nature Medicine 3 (2): 231–234. (1997). doi:10.1038/nm0297-231. PMID 9018245.
- ^ “Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia and pituitary tumors”. Cell 85 (5): 701–720. (1996). doi:10.1016/S0092-8674(00)81237-4. PMID 8646779.
- ^ “A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice”. Cell 85 (5): 733–744. (1996). doi:10.1016/S0092-8674(00)81239-8. PMID 8646781.
- ^ “The murine gene p27Kip1 is haplo-insufficient for tumour suppression.”. Nature 396 (6707): 177–180. (1998). Bibcode: 1998Natur.396..177F. doi:10.1038/24179. PMC 5395202. PMID 9823898.
- ^ a b “Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?”. Nature Reviews Cancer 4 (12): 948–955. (2004). doi:10.1038/nrc1501. PMID 15573116.
- ^ “p27 as a target for cancer therapeutics”. Cancer Cell 3 (2): 111–115. (2003). doi:10.1016/S1535-6108(03)00026-6. PMID 12620406.
- ^ “Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma”. Cancer Research 67 (19): 9238–9243. (2007). doi:10.1158/0008-5472.CAN-07-1375. PMID 17909030.
- ^ “Regulation of the CDK inhibitor p27 and its deregulation in cancer”. Journal of Cell Physiology 183 (1): 10–17. (2000). doi:10.1002/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I. PMID 10699961.
[続きの解説]
「CIP/KIP」の続きの解説一覧
- 1 CIP/KIPとは
- 2 CIP/KIPの概要
- 3 がんや他の疾患における役割
- CIP/KIPのページへのリンク
