BUB1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/08/13 15:06 UTC 版)
BUB1（budding uninhibited by benzimidazoles 1）は、ヒトではBUB1遺伝子にコードされる酵素（プロテインキナーゼ）である[5][6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169679 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027379 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Entrez Gene: BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)”. 2023年6月10日閲覧。
- ^ “Mutations of mitotic checkpoint genes in human cancers”. Nature 392 (6673): 300–3. (Mar 1998). Bibcode: 1998Natur.392..300C. doi:10.1038/32688. PMID 9521327.
- ^ “The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase”. Molecular and Cellular Biology 14 (12): 8282–91. (Dec 1994). doi:10.1128/mcb.14.12.8282. PMC 359367. PMID 7969164.
- ^ “The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores”. Structure 17 (1): 105–16. (Jan 2009). doi:10.1016/j.str.2008.10.015. PMC 2683949. PMID 19141287.
- ^ “Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1”. Developmental Cell 13 (5): 663–76. (Nov 2007). doi:10.1016/j.devcel.2007.09.005. PMID 17981135.
- ^ PDB: 3E7E; “Structure and substrate recruitment of the human spindle checkpoint kinase Bub1”. Mol. Cell 32 (3): 394–405. (November 2008). doi:10.1016/j.molcel.2008.09.017. PMC 2644263. PMID 18995837.
- ^ “UniProt”. www.uniprot.org. 2023年6月11日閲覧。
- ^ a b “BUB1 protein (Homo sapiens) - STRING interaction network”. STRING (Search Tool for the Retrieval of Interacting Genes/Proteins). European Molecular Biology Laboratory. 2011年7月18日時点のオリジナルよりアーカイブ。2010年6月29日閲覧。
- ^ “Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint”. Molecular Cell 16 (3): 387–97. (Nov 2004). doi:10.1016/j.molcel.2004.09.031. PMID 15525512.
- ^ “KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome”. The Journal of Biological Chemistry 282 (6): 3672–9. (Feb 2007). doi:10.1074/jbc.M609376200. PMID 17158872.
- ^ “Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity”. The Journal of Cell Biology 153 (6): 1239–50. (Jun 2001). doi:10.1083/jcb.153.6.1239. PMC 2192030. PMID 11402067.
- ^ “Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression”. Journal of Cell Science 117 (Pt 8): 1577–89. (Mar 2004). doi:10.1242/jcs.01006. PMID 15020684.
- ^ “Timing and checkpoints in the regulation of mitotic progression”. Developmental Cell 7 (1): 45–60. (Jul 2004). doi:10.1016/j.devcel.2004.06.006. PMID 15239953.
- ^ a b c “Bub1 regulates chromosome segregation in a kinetochore-independent manner”. The Journal of Cell Biology 185 (5): 841–58. (Jun 2009). doi:10.1083/jcb.200902128. PMC 2711590. PMID 19487456.
- ^ “Regulation of APC-Cdc20 by the spindle checkpoint”. Current Opinion in Cell Biology 14 (6): 706–14. (Dec 2002). doi:10.1016/S0955-0674(02)00382-4. PMID 12473343.
- ^ “Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation”. Molecular and Cellular Biology 21 (15): 5190–9. (Aug 2001). doi:10.1128/MCB.21.15.5190-5199.2001. PMC 87243. PMID 11438673.
- ^ “Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis”. Proceedings of the National Academy of Sciences of the United States of America 101 (52): 18012–7. (Dec 2004). Bibcode: 2004PNAS..10118012T. doi:10.1073/pnas.0408600102. PMC 539817. PMID 15604152.
- ^ “PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation”. Developmental Cell 10 (5): 575–85. (May 2006). doi:10.1016/j.devcel.2006.03.010. PMID 16580887.
- ^ “Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A”. The Journal of Biological Chemistry 282 (4): 2473–82. (Jan 2007). doi:10.1074/jbc.M605480200. PMID 17121863.
- ^ “Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1”. Cell Cycle 6 (13): 1579–85. (Jul 2007). doi:10.4161/cc.6.13.4442. PMID 17617734.
- ^ “Bub1 is essential for assembly of the functional inner centromere”. The Journal of Cell Biology 176 (7): 919–28. (Mar 2007). doi:10.1083/jcb.200609044. PMC 2064078. PMID 17389228.
- ^ “Aneuploidy: cancer's fatal flaw?”. Cancer Research 69 (13): 5289–91. (Jul 2009). doi:10.1158/0008-5472.CAN-09-0944. PMC 2917070. PMID 19549887.
- ^ “When 2+2=5: the origins and fates of aneuploid and tetraploid cells”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1786 (1): 4–14. (Sep 2008). doi:10.1016/j.bbcan.2008.07.007. PMC 2581926. PMID 18703117.
- ^ “Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding”. Journal of Virology 83 (1): 117–27. (Jan 2009). doi:10.1128/JVI.01515-08. PMC 2612341. PMID 18922873.
- ^ “Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis”. The Journal of Cell Biology 179 (2): 255–67. (Oct 2007). doi:10.1083/jcb.200706015. PMC 2064762. PMID 17938250.
- ^ “Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis”. Cancer Research 69 (1): 45–54. (Jan 2009). doi:10.1158/0008-5472.CAN-07-6330. PMC 4770788. PMID 19117986.
- ^ “Bub1: escapades in a cellular world”. Cell Cycle 6 (14): 1699–704. (Jul 2007). doi:10.4161/cc.6.14.4493. PMID 17643075.
- ^ “Caspase-independent mitotic death (CIMD)”. Cell Cycle 7 (8): 1001–5. (Apr 2008). doi:10.4161/cc.7.8.5720. PMID 18414023.
- ^ “p53-dependent apoptosis in response to spindle damage is linked to loss of Bub1”. Cancer Biology & Therapy 8 (7): 645–7. (Apr 2009). doi:10.4161/cbt.8.7.8140. PMID 19270499.
[続きの解説]
「BUB1」の続きの解説一覧
- 1 BUB1とは
- 2 BUB1の概要
- 3 構造
- 4 CIMDとの関係
- Bub1のページへのリンク
