シュードウリジン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/03/16 09:11 UTC 版)
シュードウリジン (英: pseudouridine、ギリシャ文字のΨや英文字のQで略記される)[1] は、ヌクレオシドであるウリジンの異性体。リボース環とウラシルの間のグリコシド結合のN-C結合がC-C結合に置き換わっている。RNAに知られている100を超える修飾塩基としては最も一般的で[2]、Ψはすべての生物種、ほとんどのRNAに見出されている[3][4]。
- ^ IUPAC-IUB Commission on Biochemical Nomenclature (1970). “Abbreviations and symbols for nucleic acids, polynucleotides, and their constituents”. Biochemistry 9 (20): 4022–4027. doi:10.1021/bi00822a023. PMC 1179624. PMID 5499957.
- ^ a b c Hamma, Tomoko; Ferré-D'Amaré, Adrian R. (November 2006). “Pseudouridine Synthases”. Chemistry & Biology 13 (11): 1125–1135. doi:10.1016/j.chembiol.2006.09.009. ISSN 1074-5521. PMID 17113994.
- ^ a b c d e f g Gray, Michael Charette, Michael W. (2000-05-01). “Pseudouridine in RNA: What, Where, How, and Why”. IUBMB Life 49 (5): 341–351. doi:10.1080/152165400410182. ISSN 1521-6543. PMID 10902565.
- ^ “The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA”. RNA 8 (2): 237–246. (2002). doi:10.1017/S1355838202018290. PMC 1370245. PMID 11911368.
- ^ Ge, Junhui; Yu, Yi-Tao (April 2013). “RNA pseudouridylation: new insights into an old modification”. Trends in Biochemical Sciences 38 (4): 210–218. doi:10.1016/j.tibs.2013.01.002. ISSN 0968-0004. PMC 3608706. PMID 23391857.
- ^ a b c d e f g h i j k l Rintala-Dempsey, Anne C.; Kothe, Ute (2017-01-03). “Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression?”. RNA Biology 14 (9): 1185–1196. doi:10.1080/15476286.2016.1276150. ISSN 1547-6286. PMC 5699540. PMID 28045575.
- ^ Wu, Guowei; Radwan, Mohamed K.; Xiao, Mu; Adachi, Hironori; Fan, Jason; Yu, Yi-Tao (2016-06-07). “TheTORsignaling pathway regulates starvation-induced pseudouridylation of yeast U2 snRNA”. RNA 22 (8): 1146–1152. doi:10.1261/rna.056796.116. ISSN 1355-8382. PMC 4931107. PMID 27268497.
- ^ Adachi, Hironori; De Zoysa, Meemanage D.; Yu, Yi-Tao (March 2019). “Post-transcriptional pseudouridylation in mRNA as well as in some major types of noncoding RNAs”. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862 (3): 230–239. doi:10.1016/j.bbagrm.2018.11.002. ISSN 1874-9399. PMC 6401265. PMID 30414851.
- ^ a b Penzo, M.; Guerrieri, A. N.; Zacchini, F.; Treré, D.; Montanaro, L. (2017-11-01). “RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse”. Genes 8 (11): 301. doi:10.3390/genes8110301. ISSN 2073-4425. PMC 5704214. PMID 29104216.
- ^ Keffer-Wilkes, Laura Carole; Veerareddygari, Govardhan Reddy; Kothe, Ute (2016-11-14). “RNA modification enzyme TruB is a tRNA chaperone”. Proceedings of the National Academy of Sciences 113 (50): 14306–14311. doi:10.1073/pnas.1607512113. ISSN 0027-8424. PMC 5167154. PMID 27849601.
- ^ Xu, J.; Gu, A. Y.; Thumati, N. R.; Wong JMY (2017-09-05). “Quantification of Pseudouridine Levels in Cellular RNA Pools with a Modified HPLC-UV Assay”. Genes 8 (9): 219. doi:10.3390/genes8090219. ISSN 2073-4425. PMC 5615352. PMID 28872587.
- ^ Durairaj, Anita; Limbach, Patrick A. (2008-04-07). “Improving CMC-derivatization of pseudouridine in RNA for mass spectrometric detection”. Analytica Chimica Acta 612 (2): 173–181. doi:10.1016/j.aca.2008.02.026. ISSN 1873-4324. PMC 2424252. PMID 18358863.
- ^ Kalsotra, Auinash (2016-11-02). Faculty of 1000 evaluation for Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA.. doi:10.3410/f.718875945.793524920.
- ^ a b Zhao, Yang; Karijolich, John; Glaunsinger, Britt; Zhou, Qiang (October 2016). “Pseudouridylation of 7 SK sn RNA promotes 7 SK sn RNP formation to suppress HIV ‐1 transcription and escape from latency”. EMBO Reports 17 (10): 1441–1451. doi:10.15252/embr.201642682. ISSN 1469-221X. PMC 5048380. PMID 27558685.
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