Src (遺伝子)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/07/29 14:59 UTC 版)
がん原遺伝子チロシンプロテインキナーゼSrc（Proto-oncogene tyrosine-protein kinase Src）は、ヒトにおいてSRC遺伝子にコードされる非受容体型チロシンキナーゼタンパク質である。がん原遺伝子c-Srcあるいは単にc-Srcとしても知られている。このタンパク質は他のタンパク質の特定のチロシン残基をリン酸化する。c-Srcチロシンキナーゼの活性の上昇は、他のシグナルを促進することによってがんの進行と関連していることが示唆されている[5]。c-SrcはSH2ドメイン、SH3ドメイン、チロシンキナーゼドメインを含んでいる。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000197122 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027646 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ Chang YM, Bai L, Yang I (2002). “Survey of Src activity and Src-related growth and migration in prostate cancer lines”. Proc Am Assoc Cancer Res 62: 2505a.
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[続きの解説]
「Src (遺伝子)」の続きの解説一覧
- 1 Src (遺伝子)とは
- 2 Src (遺伝子)の概要
- 3 発見
- 4 薬剤標的として
- Src (遺伝子)のページへのリンク
