流加培養とは? わかりやすく解説

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流加培養

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/04/15 05:47 UTC 版)

流加培養(りゅうかばいよう、フェッドバッチ、fed-batch culture)は、微生物や動物細胞の工業的な液体培養法のひとつである。半回分培養(はんかいぶんばいよう、semi-batch culture)ともいう。


  1. ^ 山根恒夫「半回分発酵の速度論」発酵工学会誌、第56巻第4号、1978年、310-322頁。
  2. ^ 山根恒夫、中野秀雄、加藤雅士、岩崎雄吾、河原崎泰昌、志水元亨、『新版生物反応工学』 第2章 微生物・動物細胞の培養工学、2.4 微生物の培養法とその操作法、産業図書(株)、東京、2016年、51頁。
  3. ^ Tsuneo Yamanè, Shoichi Shimizu (1984) “Fed-batch Techniques in Microbial Processes” Advances in Biochem Eng/Biotechnol, 30:147-194.
  4. ^ S. John Pirt (1975) "Principles of Microbe and Cell Cultivation" Blackwell Scientific Publications, p. 211.
  5. ^ Henry C. Lim and Hwa Sung Shin (2013) "Fed-Batch Cultures: Principles and Applications of Semi-Batch Bioreactors", Cambridge University Press, 32 Avenue of the Americas, New York, NY 10013-2473, USA.
  6. ^ V. H. Edwards, M. J. Gottschalk, A. Y. Noojin, 111, L. B. Tuthill, and A. L. Tannahill (1970) "Extended Culture: The Growth of Candida Utilis at Controlled Acetate Concentrations" Biotechnol. Bioeng., 975-999.
  7. ^ Henry Y. Wang, Dr. Charles L. Cooney, Daniel I. C. Wang (1979) "Computer control of bakers' yeast production" Biotechnol. Bioeng., 21(6), 975-995.
  8. ^ O Mendoza-Vega, J. Sabatie, S. W. Brown (1994) "Industrial-Production of Heterologous Proteins by Fed-Batch Cultures of the Yeast Saccharomyces-cerevisiae" FEMS Microbiology Reviews, 15:369-410.
  9. ^ Zhou Jiang, Kurt Droms, Zhaohui Geng, Susan Casnocha, Zhihua Xiao, Steve Gorfien and Scott J. Jacobia (2012) "Fed-Batch Cell Culture, Process Optimization--A Rationally Integrated Approach--" BioProcess International,10(3), 40-45.
  10. ^ Dieter Riesenberg (1991) ”High-cell-density cultivation of Escherichia coliCurr Opin Biotechnol, 2, 380-384.
  11. ^ L. Yee, Harvey W. Blanch (1992) “Recombinant protein expression in high cell density fed-batch cultures of Escherichia coli”. Bio/Technology (N Y), 10,1550-1556.
  12. ^ Sang Yup Lee (1996) "High cell-density culture of Escherichia coli" Trends Biotechnol., 14:98-105.
  13. ^ Joseph Shiloach, Rephael Fass (2005) "Growing E. coli to high cell density--a historical perspective on method development" Biotechnol Adv 2005, 23:345-357.
  14. ^ a b Michimasa Kishimoto and Hideyuki Suzuki (1995) "Application of an Expert System to High Cell Density Cultivation of Escherichia coli", J. Ferment. Bioeng., 80, 58-62.
  15. ^ Neubauer P and Winter J (2003) "Expression and fermentation strategies for recombinant protein production in Escherichia coli". In: Merten OW et al. (Eds). Recombinant Protein Production with prokaryotic and eukaryotic cells. A comparative view on host physiology. 2001, Kluwer Academic Publisher, Dordrecht, The Netherlands. Therapeutic proteins from the inclusion bodies of Escherichia coli. Adv Biochem Eng/Biotechnol 2003, 85:43-93.
  16. ^ Yamané, Hirano; Shigeki (1977). “Semi-batch Culture of Microorganisms with Constant Feed of Substrate - A Mathematical Simulation -”. J Fermet Technol 55: 156-165. 
  17. ^ Tsuneo Yamane and Shigeki Hirano (1977) "Semi-batch Culture of Microorganisms with Constant Feed of Substrate-An Experimental Study" J Ferment Technol,55:380-387.
  18. ^ Tsuneo Yamane, Michimasa Kishimoto, Fumitake Yoshida (1974) "Semi-batch Culture of Methanol-assimilating Bacteria with Exponentially Increased Methanol Feed" J Ferment Technol, 54:229-240.
  19. ^ Fishman, V. M. and Biryukov, V. V. (1974) “Kinetic model of secondary metabolite production and its use in computation of optimal conditions” Biotechnol. Bioeng. Symp. No. 4, 647-662.
  20. ^ Hiromu Ohno, Eiji Nakanishi and Takeichiro Takamatsu (1976) “Optimal Control of a Semibatch Fermentation”, Biotechnol. Bioeng., 18, 847-864.
  21. ^ Tsuneo Yamane, Tatsuo Kume, Eizo Sada and Takeichiro Takamatsu (1977) “A simple optimization technique for fed-batch culture”, J. Ferment. Technol., 55, 587-598.
  22. ^ Oberle, H.J. and Sothmann, B. (1999) “Numerical Computation of Optimal Feed Rates for a Fed-Batch Fermentation Model” Journal of Optimization Theory and Applications 100, 1–13.
  23. ^ 塩谷捨明、清水 浩、Patoomporn Chim-anage, 管 健一 (1991) "比増殖速度をもとにした流加培養系の最適化とその実現", 化学工学論文集、17, 572-578.
  24. ^ 塩谷捨明 (1995) "培養操作の最適化とその実現", 計測と制御, 34, 11-17.
  25. ^ Nguyen Hieu Nghia, Yoichi Kumada, Michimasa Kishimoto, and Jun-ichi Horiuchi (2021) "Effective production of single-chain variable fragment (scFv) antibody using recombinant Escherichia coli by DO-stat fed-batch culture", J. Biosci. Bioeng., 132,56-63.
  26. ^ Takahiro Suzuki, Tsuneo Yamane and Shoichi Shimizu (1986) “Control of carbon source supply and dissolved oxygen by use of carbon dioxide concentration of exhaust gas in fed-batch culture” J. Ferment. Technol., 64, 317-326.
  27. ^ Takahiro Suzuki, Yoshinao Mushiga, Tsuneo Yamane and Shoichi Shimizu (1988) “Mass production of lipase by fed-batch culture of Pseudomonas fluorescensAppl. Microbiol. Biotechnol., 27, 417-422.
  28. ^ Shuichi Aiba, Siro Nagai and Yoshihiro Nishizawa (1976) “Fed Batch Culture of Saccharomyces cerevisiae:A Perspective of Computer Control to Enhance the Productivity in Baker’s Yeast Cultivation”, Biotechnol. Bioeng., 18,1001-1016.
  29. ^ Takahiro Suzuki, Tsuneo Yamane and Shoichi Shimizu (1987) “Mass production of thiostrepton by fed-batch culture of Streptomyces laurenti with pH-stat modal feeding of multi-substrate” Appl. Microbiol. Biotechnol., 25, 526-531.
  30. ^ Takahiro Suzuki, Tsuneo Yamane and Shoichi Shimizu (1988) “Effect and control of glucose feeding on bacitracin production by fed-batch culture of Bacillus licheniformis” J. Ferment. Technol., 66, 85-91.
  31. ^ Edgardo E. Tulin, Shunsaku Ueda, Hideo Yamagata, Shigezo Udaka and Tsuneo Yamane (1992) “Effective Extracellular Production of Bacillus stearothermophilus Esterase by pH-Stat Modal Fed-Batch Culture of Recombinant Bacillus brevis”, Biotechnol. Bioeng., 40, 844-850.
  32. ^ [15] Takahiro Suzuki, Tsuneo Yamane and Shoichi Shimizu (1990) "Phenomenological background and some preliminary trials of automated substrate supply in pH-stat modal fed-batch culture utilizing setpoint of high limit" J. Ferment. Bioeng., 69: 292-297.
  33. ^ Kazuto Ishihara, Takahiro Suzuki, Tsuneo Yamane and Shoichi Shimizu (1989),“Effective production of Pseudomonas fluorescens lipase by semi-batch culture with turbidity-dependent automatic feeding of both olive oil and iron ion”, Applied Microbiology and Biotechnology, 31, 45-48.
  34. ^ Tsuneo Yamane, Wataru Hibino, Kazuto Ishihara, Yasuyuki Kadotani and Minoru Kominami (1992) “Fed-batch culture automated by uses of continuously measured cell concentration and culture volume”, Biotechnol. Bioeng., 39, 550-555.
  35. ^ Wataru Hibino, Yasuyuki Kadotani, Minoru Kominami and Tsuneo Yamane (1993) “Three automated feeding strategies of natural complex nutrients utilizing on-line turbidity values in fed-batch culture: A case study on the cultivation of a marine microorganism” J. Ferment. Bioeng, 75, 443-450.
  36. ^ Yasuyuki Kadotani, Kohji Miyamoto, Naoto Mishima, Minoru Kominami and Tsuneo Yamane (1995) “Acquisition of data from on-line laser turbidimeter and calculation of some kinetic variables in computer-coupled automated fed-batch culture”, J. Ferment. Bioeng., 80, 63-70.
  37. ^ Tsuneo Yamane, Morio Matsuda and Eizo Sada (1981) "Application of porous Teflon tubing method to automatic fed-batch culture of microorganisms. II. Automatic constant-value control of fed substrate (ethanol) concentration in semi-batch culture of yeast" Biotechnol. and Bioeng., 23(11), 2509-2524.
  38. ^ 山根恒夫、塩谷捨明 編 『バイオプロセスの知的制御』 共立出版(株)、1997年。
  39. ^ Jeong Seok Lee, Sang Yup Lee, Suwon Park, Anton P. J. Middelberg (1999) "Control of fed-batch fermentations" Biotechnol Adv 1999, 17:29-48.
  40. ^ Katie F. Wlaschin, Wei-Shou Hu(2006) "Fed-batch culture and dynamic nutrient feeding" Adv Biochem Engin/Biotechnol 2006, 101:43-74.
  41. ^ 岸本通雅、堀内淳一、藤原伸介、熊田陽一 (2018)『新生物化学工学(第3版)』3-4-5 統計的方法を利用したモデル、三共出版(株)、56-58頁.
  42. ^ 岸本通雅、堀内淳一、藤原伸介、熊田陽一 (2018)『新生物化学工学(第3版)』4-2-1 ファジィ制御、三共出版(株)、90-94頁.
  43. ^ Jun-ichi Horiuchi, Kohki Hiraga(1999) “Industrial application of fuzzy control to large-scale recombinant vitamine B2 production” J. Biosci. Bioeng., 87:365-371.
  44. ^ Christopher J, Hewitt, Alvin W, Nienow (2007) "The scale-up of microbial batch and fed-batch fermentation processes" Adv Appl Microbiol 2007, 62:105-135.
  45. ^ Gunnar Liden (2002) "Understanding the bioreactor" Bioprocess and Biosystems Engineering 2002, 24:273-279.





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