N-Myc
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/08/13 14:42 UTC 版)
N-Mycは、ヒトではMYCN遺伝子にコードされるタンパク質である。bHLHe37（class E basic helix-loop-helix protein 37）としても知られる。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134323 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037169 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)”. 2022年12月2日閲覧。
- ^ “N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.”. Genes Dev. 16 (20): 2699–712. (2002). doi:10.1101/gad.1021202. PMC 187459. PMID 12381668.
- ^ “Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.”. Cell Growth Differ. 3 (6): 385–90. (1992). PMID 1419902.
- ^ “MYCN opposite strand/antisense RNA [Homo sapiens]”. Entrez Gene Database. National Center for Biotechnology Information, U.S. National Library of Medicine. 2022年12月2日閲覧。
- ^ “NCYM, a Cis-Antisense Gene of MYCN, Encodes a De Novo Evolved Protein That Inhibits GSK3β Resulting in the Stabilization of MYCN in Human Neuroblastomas”. PLOS Genetics 10 (1): e1003996. (2014). doi:10.1371/journal.pgen.1003996. PMC 3879166. PMID 24391509.
- ^ “Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas”. Nat. Genet. 4 (2): 191–4. (June 1993). doi:10.1038/ng0693-191. PMID 8102299.
- ^ “N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas.”. Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. (1985). Bibcode: 1985PNAS...82.3736E. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423.
- ^ “Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.”. Science 224 (4653): 1121–4. (1984). Bibcode: 1984Sci...224.1121B. doi:10.1126/science.6719137. PMID 6719137.
- ^ “Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc”. Science 251 (4998): 1211–7. (March 1991). Bibcode: 1991Sci...251.1211B. doi:10.1126/science.2006410. PMID 2006410.
- ^ “Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc”. Oncogene 18 (15): 2489–98. (April 1999). doi:10.1038/sj.onc.1202611. PMID 10229200.
- ^ “Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma”. Cancer Cell 15 (1): 67–78. (January 2009). doi:10.1016/j.ccr.2008.12.005. PMID 19111882.
- ^ “Drugging MYCN through an Allosteric Transition in Aurora Kinase A.”. Cancer Cell 26 (3): 414–27. (27 August 2014). doi:10.1016/j.ccr.2014.07.015. PMC 4160413. PMID 25175806.
- ^ “Surf the post-translational modification network of p53 regulation”. International Journal of Biological Sciences 8 (5): 672–84. (2012). doi:10.7150/ijbs.4283. PMC 3354625. PMID 22606048.
[続きの解説]
「N-Myc」の続きの解説一覧
- 1 N-Mycとは
- 2 N-Mycの概要
- 3 機能
- 4 関連文献
- 5 関連項目
- NMYCのページへのリンク
