MSH6
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/12/11 10:00 UTC 版)
MSH6 (mutS homolog 6) は、ヒトではMSH6遺伝子にコードされる、DNAミスマッチ修復に関与するタンパク質である。GTBP（G/T binding protein）、p160とも呼ばれる。MSH6タンパク質はDNA損傷修復に関与するMutS（Mutator S）ファミリーのタンパク質である。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116062 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005370 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c d “Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair”. Genes Dev. 10 (4): 407–20. (1996). doi:10.1101/gad.10.4.407. PMID 8600025.
- ^ a b “Identification of mismatch repair genes and their role in the development of cancer”. Current Opinion in Genetics & Development 5 (3): 382–95. (1995). doi:10.1016/0959-437X(95)80055-7. PMID 7549435.
- ^ “hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6”. PNAS 93 (24): 13629–34. (1996). Bibcode: 1996PNAS...9313629A. doi:10.1073/pnas.93.24.13629. PMC 19374. PMID 8942985.
- ^ Friedberg, Errol C. (1995). DNA repair and mutagenesis. Graham C. Walker, Wolfram Siede. Washington, D.C.: ASM Press. ISBN 1-55581-088-8. OCLC 31606101
- ^ a b c d “hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA”. Molecular Cell 3 (2): 255–61. (1999). doi:10.1016/S1097-2765(00)80316-0. PMID 10078208.
- ^ “The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch”. Cell 91 (7): 995–1005. (1997). doi:10.1016/S0092-8674(00)80490-0. PMID 9428522.
- ^ a b “Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree”. J. Med. Genet. 38 (5): 318–22. (2001). doi:10.1136/jmg.38.5.318. PMC 1734864. PMID 11333868.
- ^ a b “MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)”. Proc. Natl. Acad. Sci. U.S.A. 107 (49): 21098–103. (2010). Bibcode: 2010PNAS..10721098V. doi:10.1073/pnas.1015541107. PMC 3000294. PMID 21078976.
- ^ a b c d “Modulation of mismatch repair and genomic stability by miR-155”. Proc. Natl. Acad. Sci. U.S.A. 107 (15): 6982–7. (2010). Bibcode: 2010PNAS..107.6982V. doi:10.1073/pnas.1002472107. PMC 2872463. PMID 20351277.
- ^ “Genome-wide epigenetic regulation of miRNAs in cancer”. Cancer Res. 73 (2): 473–7. (2013). doi:10.1158/0008-5472.CAN-12-3731. PMID 23316035.
- ^ “Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors”. Genome Biol. 14 (11): R126. (2013). doi:10.1186/gb-2013-14-11-r126. PMC 4053776. PMID 24257477.
- ^ “Insights into epigenetic regulation of microRNA-155 expression in multiple myeloma”. Biochim. Biophys. Acta 1849 (3): 353–66. (2015). doi:10.1016/j.bbagrm.2014.12.002. PMID 25497370.
- ^ “Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155”. Nat. Med. 17 (10): 1275–82. (2011). doi:10.1038/nm.2459. PMC 3501198. PMID 21946536.
- ^ a b “BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures”. Genes & Development 14 (8): 927–39. (Apr 2000). doi:10.1101/gad.14.8.927. PMC 316544. PMID 10783165.
- ^ “MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation”. Proceedings of the National Academy of Sciences of the United States of America 100 (26): 15387–92. (Dec 2003). Bibcode: 2003PNAS..10015387W. doi:10.1073/pnas.2536810100. PMC 307577. PMID 14657349.
- ^ “Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer”. Molecular and Cellular Biology 18 (11): 6616–23. (Nov 1998). doi:10.1128/mcb.18.11.6616. PMC 109246. PMID 9774676.
- ^ “hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis”. Cancer Research 59 (4): 816–22. (Feb 1999). PMID 10029069.
- ^ “hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6”. Proceedings of the National Academy of Sciences of the United States of America 93 (24): 13629–34. (Nov 1996). Bibcode: 1996PNAS...9313629A. doi:10.1073/pnas.93.24.13629. PMC 19374. PMID 8942985.
- ^ “hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci”. Genes & Development 15 (6): 724–36. (Mar 2001). doi:10.1101/gad.191201. PMC 312660. PMID 11274057.
- ^ “Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes”. The Journal of Biological Chemistry 275 (47): 36498–501. (Nov 2000). doi:10.1074/jbc.C000513200. PMID 11005803.
- ^ “A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. The Journal of Biological Chemistry 277 (43): 40362–7. (Oct 2002). doi:10.1074/jbc.M206194200. PMID 12171929.
- ^ “Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1”. Oncogene 20 (34): 4640–9. (Aug 2001). doi:10.1038/sj.onc.1204625. PMID 11498787.
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