ドルパノールとは - わかりやすく解説 Weblio辞書

ドルパノール

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2019/08/31 10:14 UTC 版)

ドルパノール(Drupanol)は、Psoralea drupaceaeの種子から単離されるフェノールである^[1]^[2]。バクチオールと同一の化合物であると言われることがあるが、同じ分子式であるだけで化学構造は異なり、構造異性体の関係にある^[1]。ドルパノールは、アンドロゲンと同化の活性を持ち、フィトアンドロゲンである^[3]。対照的に、バクチオールは、抗アンドロゲン剤として働くことが知られている^[4]。

アンドロゲン（未訳）

Receptor

AR (A, B)

Agonists: 1-Androstenediol
1-Testosterone
1,4-Androstenedione
4-Androstenediol
4-Chlordehydromethyltestosterone
4-Hydroxytestosterone
5-Androstenediol
5α-Androst-1-ene-3,17-dione
11-Ketotestosterone
17-((1-Oxoheptyl)oxy)androstan-3-one
17-((1-Oxopentyl)oxy)androstan-3-one
17-(1-Oxopropoxy)androstan-3-one
17β-Hydroxyandrost-2-ene-2-carbonitrile
19-Norandrostenediol
19-Norandrostenedione
19-Norandrosterone
19-Nordehydrotestosterone
Adrenosterone
Androisoxazole
Androstanolone
Bolandiol
Bolasterone
Bolazine
Boldenone
Boldione
Bolenol
Bolmantalate
Calusterone
Clostebol
Cloxotestosterone
Danazol
Desogestrel
Desoxymethyltestosterone
DHT
Drostanolone
Enestebol
Epitiostanol
Ethisterone
Ethyldienolone
Ethylestrenol
Fluoxymesterone
Formebolone
Furazabol
Hexabolan
Hydroxystenozole
Levonorgestrel
Mebolazine
Medroxyprogesterone acetate
Mepitiostane
Mesabolone
Mestanolone
Mesterolone
Metandienone/Methandrostenolone
Metenolone
Metenolone acetate
Metenolone enanthate
Methandriol
Methandriol propionate
Methasterone
Methylestrenolone
Methyltestosterone
Metribolone
Mibolerone
Nandrolone
Nandrolone caproate
Nandrolone cypionate
Nandrolone cyclohexane carboxylate
Nandrolone cyclohexylpropionate
Nandrolone cyclotate
Nandrolone decanoate
Nandrolone furylpropionate
Nandrolone hexyloxyphenylpropionate
Nandrolone hydrogen succinate
Nandrolone laurate
Nandrolone phenylpropionate
Nandrolone propionate
Nandrolone undecyclate
Norboletone
Norclostebol
Norethandrolone
Norethisterone
Norgestrel
Oxabolone
Oxabolone cypionate
Oxandrolone
Oxendolone
Oxymesterone
Oxymetholone
Penmesterol
Propetandrol
Quinbolone
Quingestanol acetate
Roxibolone
Silandrone
Stanozolol
Stenbolone
Stenbolone acetate
Testolactone
Testosterone
Testosterone enanthate
Testosterone ketolaurate
Testosterone nicotinate
Testosterone propionate
Testosterone undecanoate
THG
Thiomesterone
Tibolone
Tiomesterone
Trenbolone
Trenbolone acetate
Trestolone

Mixed (SARMs): AC-262,356
Andarine
BMS-564,929
Enobosarm
LGD-2226
LGD-3303
S-23
S-40503

Antagonists: ARN-509
Benorterone
Bicalutamide
BMS-641,988
BOMT
Canrenoic acid
Canrenone
Chlormadinone acetate
Cimetidine
Cioteronel
Cyproterone
Cyproterone acetate
Delanterone
Dienogest
Drospirenone
Enzalutamide
Epitestosterone
Flutamide
Galeterone
Hydroxyflutamide
Inocoterone
Ketoconazole
Megestrol acetate
Metogest
Mifepristone
Nilutamide
Nomegestrol
Nordinone
Norgestimate
Osaterone
Oxendolone
Potassium canrenoate
R2956
Rosterolone
RU-58642
RU-58841
Spironolactone
Topterone
Zanoterone

Enzyme
(inhibitors)

20,22-Desmolase	22-ABC 3,3′-Dimethoxybenzidine 3-Methoxybenzidine Aminoglutethimide Cyanoketone Danazol Etomidate Mitotane Trilostane
17α-Hydroxylase, 17,20-Lyase	22-ABC 22-Oxime Abiraterone Bifonazole Clotrimazole Cyanoketone Cyproterone acetate Danazol Econazole Galeterone Gestrinone Isoconazole Ketoconazole L-39 Levonorgestrel Liarozole LY-207,320 MDL-27,302 Miconazole Mifepristone Orteronel Pioglitazone Rosiglitazone Spironolactone Stanozolol SU-10,603 TGF-β Tioconazole Troglitazone VN/87-1 YM116
3β-HSD (I, II)	4-MA Azastene Cyanoketone Danazol Epostane Genistein Gestrinone Levonorgestrel Metyrapone Oxymetholone Pioglitazone Rosiglitazone Trilostane Troglitazone
17β-HSD (I-XIV)	Danazol Simvastatin
5α-Reductase (I, II)	22-Oxime Alfatradiol Azelaic acid β-Sitosterol Bexlosteride Dutasteride Epitestosterone Epristeride Finasteride gamma-Linolenic acid Ganoderic acid Izonsteride L-39 Lapisteride Polyunsaturated fatty acids (α-linolenic acid, linoleic acid, γ-linolenic acid, oleic acid) Saw palmetto Turosteride Vitamin B6 Zinc
Aromatase	1,4,6-Androstatriene-3,17-dione 4-Androstene-3,6,17-trione 4-Cyclohexylaniline 4-Hydroxytestosterone 5α-DHNET Abyssinone II Aminoglutethimide Anastrozole Ascorbic acid (Vitamin C) Atamestane Bifonazole CGP-45,688 CGS-47,645 Clotrimazole DHT Difeconazole Econazole Exemestane Fadrozole Fenarimol Finrozole Formestane Imazalil Isoconazole Ketoconazole Letrozole Liarozole MEN-11066 Miconazole Minamestane Nimorazole NKS01 ORG-33,201 Penconazole Plomestane Prochloraz Propioconazole Pyridoglutethimide Rogletimide Rotenone Talarozole Testolactone Tioconazole Triadimefon Triadimenol Troglitazone Vorozole YM511 Zinc Note: 21-Hydroxylase inhibitors may also affect androgen levels as they prevent metabolism of androgen precursors.

Other

Endogenous	Androgens: Dihydrotestosterone Testosterone Antiandrogens: Epitestosterone Precursors: Cholesterol 22R-Hydroxycholesterol 20α,22R-Dihydroxycholesterol Pregnenolone 17-Hydroxypregnenolone Progesterone 17-Hydroxyprogesterone Cortodoxone/Deoxycortisol DHEA Androstenediol Androstenedione
Indirect	Estrogens/Antiestrogens (see here) GnRH agonists/antagonists (see here) Gonadotropins/Antigonadotropins (see here) Plasma proteins (SHBG, ABP, Albumin) Progestogens/Antiprogestins (see here) Prolactin
Procedures	Adrenalectomy Hypophysectomy Oophorectomy Orchiectomy

出典

^ ^a ^b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 120,473. ISBN 978-1-4757-2085-3.
^ Golovina, L. A.; Nikonov, G. K. (1973). “The structure of drupanol - A new phenol from Psoralea drupaceae”. Chemistry of Natural Compounds 9 (1): 7-9. doi:10.1007/BF00580876. ISSN 0009-3130.
^ Sasha W. Eisenman; David E. Zaurov; Lena Struwe (14 September 2012). Medicinal Plants of Central Asia: Uzbekistan and Kyrgyzstan. Springer Science & Business Media. pp. 205-. ISBN 978-1-4614-3912-7.
^ Miao, L., Ma, S. W., Fan, G. W., Wang, H., Wang, Y. F., & Chai, L. J. (2013). Bakuchiol inhibits the androgen induced-proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity. Tianjin Journal of Traditional Chinese Medicine, 5, 012.

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