β-カテニンとは - わかりやすく解説 Weblio辞書

すべての辞書から再検索する

ウィキペディア

索引トップランキングカテゴリー

β-カテニン

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/04/26 07:07 UTC 版)

β-カテニン（英: β-catenin、catenin beta-1）は、ヒトではCTNNB1遺伝子にコードされるタンパク質である^[5]。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168036 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006932 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development”. Genomics 23 (1): 272–4. (September 1994). doi:10.1006/geno.1994.1493. PMID 7829088.
^ “Wnt/beta-catenin signaling: components, mechanisms, and diseases”. Developmental Cell 17 (1): 9–26. (July 2009). doi:10.1016/j.devcel.2009.06.016. PMC 2861485. PMID 19619488.
^ “The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation”. Development 111 (4): 1029–43. (April 1991). PMID 1879348.
^ “dishevelled and armadillo act in the wingless signalling pathway in Drosophila”. Nature 367 (6458): 80–3. (January 1994). Bibcode: 1994Natur.367...80N. doi:10.1038/367080a0. PMID 7906389.
^ “A repeating amino acid motif shared by proteins with diverse cellular roles”. Cell 76 (5): 789–91. (March 1994). doi:10.1016/0092-8674(94)90353-0. PMID 7907279.
^ “beta-catenin signaling and cancer”. BioEssays 21 (12): 1021–30. (December 1999). doi:10.1002/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P. PMID 10580987.
^ “A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin”. Science 254 (5036): 1359–61. (November 1991). Bibcode: 1991Sci...254.1359M. doi:10.1126/science.1962194. PMID 1962194.
^ “From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion”. Trends in Genetics 9 (9): 317–21. (September 1993). doi:10.1016/0168-9525(93)90250-l. PMID 8236461.
^ “Terminal regions of beta-catenin come into view”. Structure 16 (3): 336–8. (March 2008). doi:10.1016/j.str.2008.02.005. PMC 2329800. PMID 18334207.
^ “Crystal structure of a full-length beta-catenin”. Structure 16 (3): 478–87. (March 2008). doi:10.1016/j.str.2007.12.021. PMC 4267759. PMID 18334222.
^ “Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity”. Journal of Biological Chemistry 282 (15): 11221–9. (April 2007). doi:10.1074/jbc.M611871200. PMC 1850976. PMID 17287208.
^ “The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis”. Mechanisms of Development 81 (1–2): 65–74. (March 1999). doi:10.1016/s0925-4773(98)00225-1. PMID 10330485.
^ “Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system”. Oncogene 19 (16): 1992–2001. (April 2000). doi:10.1038/sj.onc.1203519. PMID 10803460.
^ “Plakoglobin: role in tumorigenesis and metastasis”. International Journal of Cell Biology 2012: 1–14. (2012). doi:10.1155/2012/189521. PMC 3312339. PMID 22481945.
^ “Mechanistic insights from structural studies of beta-catenin and its binding partners”. Journal of Cell Science 120 (Pt 19): 3337–44. (October 2007). doi:10.1242/jcs.013771. PMID 17881495.
^ “Crystal structure of a beta-catenin/Tcf complex”. Cell 103 (6): 885–96. (December 2000). doi:10.1016/S0092-8674(00)00192-6. PMID 11136974.
^ “Tcf4 can specifically recognize beta-catenin using alternative conformations”. Nature Structural Biology 8 (12): 1048–52. (December 2001). doi:10.1038/nsb718. PMID 11713475.
^ “Structure of a human Tcf4-beta-catenin complex”. Nature Structural Biology 8 (12): 1053–7. (December 2001). doi:10.1038/nsb720. PMID 11713476.
^ ^a ^b “The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin”. Cell 105 (3): 391–402. (May 2001). doi:10.1016/S0092-8674(01)00330-0. PMID 11348595.
^ ^a ^b “Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex”. Genes & Development 17 (22): 2753–64. (November 2003). doi:10.1101/gad.1142603. PMC 280624. PMID 14600025.
^ ^a ^b “Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?”. Molecular Cancer 10 (1): 101. (August 2011). doi:10.1186/1476-4598-10-101. PMC 3170638. PMID 21859464.
^ “Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex”. Cell 109 (1): 47–60. (April 2002). doi:10.1016/S0092-8674(02)00679-7. PMID 11955446.
^ ^a ^b “Structure of the dimerization and beta-catenin-binding region of alpha-catenin”. Molecular Cell 5 (3): 533–43. (March 2000). doi:10.1016/S1097-2765(00)80447-5. PMID 10882138.
^ “Crystal structure of a beta-catenin/BCL9/Tcf4 complex”. Molecular Cell 24 (2): 293–300. (October 2006). doi:10.1016/j.molcel.2006.09.001. PMID 17052462.
^ “Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions”. Genes & Development 18 (18): 2225–30. (September 2004). doi:10.1101/gad.317604. PMC 517514. PMID 15371335.
^ Liu, Chunming; Li, Yiming; Semenov, Mikhail; Han, Chun; Baeg, Gyeong Hun; Tan, Yi; Zhang, Zhuohua; Lin, Xinhua et al. (2002-03-22). “Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism”. Cell 108 (6): 837–847. doi:10.1016/s0092-8674(02)00685-2. ISSN 0092-8674. PMID 11955436.
^ “The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin”. Journal of Molecular Biology 360 (1): 133–44. (June 2006). doi:10.1016/j.jmb.2006.04.064. PMID 16753179.
^ “beta-catenin destruction complex: insights and questions from a structural perspective”. Oncogene 25 (57): 7482–91. (December 2006). doi:10.1038/sj.onc.1210055. PMID 17143292.
^ “Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin”. Proceedings of the National Academy of Sciences of the United States of America 108 (5): 1937–42. (February 2011). Bibcode: 2011PNAS..108.1937F. doi:10.1073/pnas.1017063108. PMC 3033301. PMID 21245303.
^ “Inhibition of GSK3 by Wnt signalling--two contrasting models”. Journal of Cell Science 124 (Pt 21): 3537–44. (November 2011). doi:10.1242/jcs.091991. PMID 22083140.
^ ^a ^b “Balancing cell adhesion and Wnt signaling, the key role of beta-catenin”. Current Opinion in Genetics & Development 16 (1): 51–9. (February 2006). doi:10.1016/j.gde.2005.12.007. PMID 16377174.
^ “Entrez Gene: catenin (cadherin-associated protein)”. 2020年3月31日閲覧。
^ “An ensemble of flexible conformations underlies mechanotransduction by the cadherin-catenin adhesion complex”. Proc Natl Acad Sci USA 116 (43): 21545–21555. (October 22, 2019). doi:10.1073/pnas.1911489116. PMC 6815173. PMID 31591245.
^ “Regulation of cell-cell adhesion by the cadherin-catenin complex”. Biochemical Society Transactions 36 (Pt 2): 149–55. (April 2008). doi:10.1042/BST0360149. PMC 3368607. PMID 18363555.
^ “beta-Catenin: a pivot between cell adhesion and Wnt signalling”. Current Biology 15 (2): R64–7. (January 2005). doi:10.1016/j.cub.2004.12.058. PMID 15668160.
^ “Lack of beta-catenin affects mouse development at gastrulation”. Development 121 (11): 3529–37. (November 1995). PMID 8582267.
^ ^a ^b “Maintaining embryonic stem cell pluripotency with Wnt signaling”. Development 138 (20): 4341–50. (October 2011). doi:10.1242/dev.066209. PMC 3177306. PMID 21903672.
^ “Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos”. Mechanisms of Development 57 (2): 191–8. (July 1996). doi:10.1016/0925-4773(96)00546-1. PMID 8843396.
^ “Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway”. The Journal of Cell Biology 136 (5): 1123–36. (March 1997). doi:10.1083/jcb.136.5.1123. PMC 2132470. PMID 9060476.
^ “Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin”. Mechanisms of Development 53 (2): 261–73. (October 1995). doi:10.1016/0925-4773(95)00442-4. PMID 8562427.
^ Control of cell polarity and asymmetric division in C. elegans. 101. (2012). 55–76. doi:10.1016/B978-0-12-394592-1.00003-X. ISBN 9780123945921. PMID 23140625
^ “E-cadherin/β-catenin complex and the epithelial barrier”. Journal of Biomedicine & Biotechnology 2011: 1–6. (2011). doi:10.1155/2011/567305. PMC 3191826. PMID 22007144.
^ “Role of beta-catenin in adult cardiac remodeling”. Cell Cycle 6 (17): 2120–6. (September 2007). doi:10.4161/cc.6.17.4632. PMID 17786052.
^ “Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm”. Developmental Cell 3 (2): 171–81. (August 2002). doi:10.1016/s1534-5807(02)00206-x. PMID 12194849.
^ “Lack of beta-catenin affects mouse development at gastrulation”. Development 121 (11): 3529–37. (November 1995). PMID 8582267.
^ ^a ^b “N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes”. Journal of Cell Science 109 ( Pt 1) (1): 11–20. (January 1996). PMID 8834786.
^ “Identification of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation”. Cellular and Molecular Life Sciences 67 (5): 781–96. (March 2010). doi:10.1007/s00018-009-0219-8. PMID 19997769.
^ “Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling”. Journal of Molecular and Cellular Cardiology 31 (2): 333–43. (February 1999). doi:10.1006/jmcc.1998.0886. PMID 10093046.
^ “Alterations in adhesion junction precede gap junction remodelling during the development of heart failure in cardiomyopathic hamsters”. Cardiovascular Research 92 (1): 95–105. (October 2011). doi:10.1093/cvr/cvr182. PMID 21693625.
^ “Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts”. The Journal of Biological Chemistry 281 (41): 30979–89. (October 2006). doi:10.1074/jbc.M603916200. PMID 16920707.
^ “Expression and redistribution of β-catenin in the cardiac myocytes of left ventricle of spontaneously hypertensive rat”. Journal of Molecular Histology 44 (5): 565–73. (October 2013). doi:10.1007/s10735-013-9507-6. PMID 23591738.
^ “Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death”. Basic Research in Cardiology 105 (5): 597–608. (September 2010). doi:10.1007/s00395-010-0101-8. PMID 20376467.
^ “Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling”. Molecular and Cellular Biology 31 (6): 1134–44. (March 2011). doi:10.1128/MCB.01025-10. PMC 3067899. PMID 21245375.
^ “Loss of cadherin-binding proteins β-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis”. Molecular and Cellular Biology 32 (6): 1056–67. (March 2012). doi:10.1128/MCB.06188-11. PMC 3295003. PMID 22252313.
^ ^a ^b “β-catenin mediates stress resilience through Dicer1/microRNA regulation”. Nature 516 (7529): 51–5. (December 2014). Bibcode: 2014Natur.516...51D. doi:10.1038/nature13976. PMC 4257892. PMID 25383518.
^ “Dilated cardiomyopathy: a disease of the intercalated disc?”. Trends in Cardiovascular Medicine 13 (1): 30–8. (January 2003). doi:10.1016/s1050-1738(02)00209-8. PMID 12554098.
^ ^a ^b “Estrogen receptor alpha up-regulation and redistribution in human heart failure”. FASEB Journal 20 (7): 926–34. (May 2006). doi:10.1096/fj.05-5148com. PMID 16675850.
^ “COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer”. Nucleic Acids Research 39 (Database issue): D945–50. (January 2011). doi:10.1093/nar/gkq929. PMC 3013785. PMID 20952405.
^ “Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation”. The British Journal of Dermatology 151 (1): 157–64. (July 2004). doi:10.1111/j.1365-2133.2004.06048.x. PMID 15270885.
^ “Wnt/β-catenin signalling in prostate cancer”. Nature Reviews. Urology 9 (8): 418–28. (August 2012). doi:10.1038/nrurol.2012.116. PMID 22710668.
^ “beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst”. American Journal of Clinical Pathology 120 (5): 732–6. (November 2003). doi:10.1309/EALEG7LD6W7167PX. PMID 14608900.
^ “beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee”. Journal of Clinical Oncology 23 (31): 7951–7. (November 2005). doi:10.1200/JCO.2005.01.5479. PMID 16258095.
^ “Nuclear translocation of beta-catenin in colorectal cancer”. British Journal of Cancer 82 (10): 1689–93. (May 2000). doi:10.1054/bjoc.1999.1112. PMC 2374509. PMID 10817505.
^ “Wnt/beta-catenin signaling and small molecule inhibitors”. Current Pharmaceutical Design 19 (4): 634–64. (2013). doi:10.2174/1381612811306040634. PMC 3529405. PMID 23016862.
^ “An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid”. Nature Communications 3 (2): 680. (February 2012). Bibcode: 2012NatCo...3..680D. doi:10.1038/ncomms1680. PMC 3293410. PMID 22353711.
^ “Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling”. Science Translational Medicine 4 (148): 148ra117. (August 2012). doi:10.1126/scitranslmed.3003808. PMC 3631420. PMID 22914623.
^ “Endogenous and exogenous galectin-3 promote the adhesion of tumor cells with low expression of MUC1 to HUVECs through upregulation of N-cadherin and CD44”. Laboratory Investigation 98 (12): 1642–1656. (2018-08-31). doi:10.1038/s41374-018-0119-3. PMID 30171204.
^ 臨床試験番号 NCT02117362 研究名 "Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanoma" - ClinicalTrials.gov
^ “Calcium-mediated repression of β-catenin and its transcriptional signaling mediates neural crest cell death in an avian model of fetal alcohol syndrome”. Birth Defects Research. Part A, Clinical and Molecular Teratology 91 (7): 591–602. (July 2011). doi:10.1002/bdra.20833. PMC 4827605. PMID 21630427.
^ “Association of the APC tumor suppressor protein with catenins”. Science 262 (5140): 1734–7. (December 1993). Bibcode: 1993Sci...262.1734S. doi:10.1126/science.8259519. PMID 8259519.
^ ^a ^b ^c ^d “Expression and interaction of different catenins in colorectal carcinoma cells”. International Journal of Molecular Medicine 8 (6): 695–8. (December 2001). doi:10.3892/ijmm.8.6.695. PMID 11712088.
^ “Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein”. Journal of Molecular Biology 327 (2): 359–67. (March 2003). doi:10.1016/S0022-2836(03)00144-X. PMID 12628243.
^ ^a ^b “The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer”. International Journal of Oncology 18 (4): 843–7. (April 2001). doi:10.3892/ijo.18.4.843. PMID 11251183.
^ “Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC”. Nature Cell Biology 3 (9): 793–801. (September 2001). doi:10.1038/ncb0901-793. PMID 11533658.
^ “Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein”. Proceedings of the National Academy of Sciences of the United States of America 99 (9): 5959–64. (April 2002). Bibcode: 2002PNAS...99.5959K. doi:10.1073/pnas.092143199. PMC 122884. PMID 11972058.
^ “DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95”. Genes to Cells 2 (6): 415–24. (June 1997). doi:10.1046/j.1365-2443.1997.1310329.x. PMID 9286858.
^ “Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex”. The EMBO Journal 20 (22): 6203–12. (November 2001). doi:10.1093/emboj/20.22.6203. PMC 125720. PMID 11707392.
^ “Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level”. Genes to Cells 3 (6): 395–403. (June 1998). doi:10.1046/j.1365-2443.1998.00198.x. PMID 9734785.
^ “Regulation of the Wnt signaling pathway by disabled-2 (Dab2)”. The EMBO Journal 22 (12): 3084–94. (June 2003). doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.
^ “Linking beta-catenin to androgen-signaling pathway”. The Journal of Biological Chemistry 277 (13): 11336–44. (March 2002). doi:10.1074/jbc.M111962200. PMID 11792709.
^ “Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells”. Molecular Endocrinology 18 (10): 2388–401. (October 2004). doi:10.1210/me.2003-0436. PMID 15256534.
^ “Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor”. Molecular Endocrinology 18 (1): 70–85. (January 2004). doi:10.1210/me.2003-0189. PMID 14593076.
^ “A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4”. The Journal of Biological Chemistry 278 (33): 30828–34. (August 2003). doi:10.1074/jbc.M301208200. PMID 12799378.
^ ^a ^b “Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis”. Oncogene 22 (36): 5602–13. (August 2003). doi:10.1038/sj.onc.1206802. PMID 12944908.
^ “Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells”. The Journal of Biological Chemistry 277 (23): 20702–10. (June 2002). doi:10.1074/jbc.M200545200. PMID 11916967.
^ “Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway”. Nature 422 (6934): 905–9. (April 2003). Bibcode: 2003Natur.422..905T. doi:10.1038/nature01570. PMID 12712206.
^ “HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells”. International Journal of Molecular Medicine 7 (4): 385–8. (April 2001). doi:10.3892/ijmm.7.4.385. PMID 11254878.
^ ^a ^b “A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines”. Cancer Research 54 (23): 6282–7. (December 1994). PMID 7954478.
^ “Vinculin is associated with the E-cadherin adhesion complex”. The Journal of Biological Chemistry 272 (51): 32448–53. (December 1997). doi:10.1074/jbc.272.51.32448. PMID 9405455.
^ “Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia”. The Journal of Cell Biology 130 (2): 461–71. (July 1995). doi:10.1083/jcb.130.2.461. PMC 2199929. PMID 7542250.
^ “CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells”. Biochemical and Biophysical Research Communications 294 (4): 900–5. (June 2002). doi:10.1016/S0006-291X(02)00551-X. PMID 12061792.
^ ^a ^b ^c ^d “The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton”. The Journal of Biological Chemistry 273 (15): 9078–84. (April 1998). doi:10.1074/jbc.273.15.9078. PMID 9535896.
^ ^a ^b ^c “Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription”. Cancer Research 61 (4): 1671–7. (February 2001). PMID 11245482.
^ ^a ^b “Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin”. Molecular and Cellular Biology 18 (12): 7216–24. (December 1998). doi:10.1128/mcb.18.12.7216. PMC 109303. PMID 9819408.
^ “Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin”. Experimental Cell Research 294 (2): 345–55. (April 2004). doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.
^ ^a ^b “EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma”. Hepatology 38 (1): 178–86. (July 2003). doi:10.1053/jhep.2003.50270. PMID 12830000.
^ ^a ^b “p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction”. Molecular and Cellular Biology 23 (7): 2287–97. (April 2003). doi:10.1128/MCB.23.7.2287-2297.2003. PMC 150740. PMID 12640114.
^ “Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation”. Proceedings of the National Academy of Sciences of the United States of America 100 (7): 3989–94. (April 2003). Bibcode: 2003PNAS..100.3989K. doi:10.1073/pnas.0736565100. PMC 153035. PMID 12634428.
^ “UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug”. Oncogene 21 (13): 2037–50. (March 2002). doi:10.1038/sj.onc.1205271. PMID 11960376.
^ “Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin”. Journal of Cell Science 105 ( Pt 4) (4): 923–34. (August 1993). PMID 8227214.
^ ^a ^b “Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence”. Oncogene 15 (1): 71–8. (July 1997). doi:10.1038/sj.onc.1201160. PMID 9233779.
^ ^a ^b “MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures”. Biochemical and Biophysical Research Communications 270 (3): 903–9. (April 2000). doi:10.1006/bbrc.2000.2471. PMID 10772923.
^ “Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation”. Biochimica et Biophysica Acta 1535 (1): 21–35. (December 2000). doi:10.1016/S0925-4439(00)00079-X. PMID 11113628.
^ “Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes”. The Journal of Cell Biology 128 (5): 949–57. (March 1995). doi:10.1083/jcb.128.5.949. PMC 2120395. PMID 7876318.
^ “Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress”. The Biochemical Journal 368 (Pt 2): 471–81. (December 2002). doi:10.1042/BJ20011804. PMC 1222996. PMID 12169098.
^ ^a ^b “The fate of E- and P-cadherin during the early stages of apoptosis”. Cell Death and Differentiation 6 (4): 377–86. (April 1999). doi:10.1038/sj.cdd.4400504. PMID 10381631.
^ “Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling”. Cancer Research 68 (13): 5086–95. (July 2008). doi:10.1158/0008-5472.CAN-07-2325. PMID 18593907.
^ “A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells”. Journal of Cell Science 116 (Pt 24): 4985–95. (December 2003). doi:10.1242/jcs.00815. PMID 14625392.
^ “N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane”. The Journal of Biological Chemistry 278 (19): 17269–76. (May 2003). doi:10.1074/jbc.M211452200. PMID 12604612.
^ “Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions”. Journal of Cell Science 113 ( Pt 16) (16): 2829–36. (August 2000). PMID 10910767.
^ “p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction”. The European Journal of Neuroscience 13 (2): 241–7. (January 2001). doi:10.1046/j.1460-9568.2001.01376.x. PMID 11168528.
^ ^a ^b “Regulation of beta-catenin function by the IkappaB kinases”. The Journal of Biological Chemistry 276 (45): 42276–86. (November 2001). doi:10.1074/jbc.M104227200. PMID 11527961.
^ “A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity”. Cell Adhesion and Communication 5 (4): 283–96. (June 1998). doi:10.3109/15419069809040298. PMID 9762469.
^ “Assembly of the cadherin-catenin complex in vitro with recombinant proteins”. Journal of Cell Science 107 ( Pt 12) (12): 3655–63. (December 1994). PMID 7706414.
^ “E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton”. Journal of Cell Science 111 ( Pt 8) (8): 1071–80. (April 1998). PMID 9512503.
^ ^a ^b “ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas”. The Journal of Biological Chemistry 277 (25): 22692–8. (June 2002). doi:10.1074/jbc.M201975200. PMID 11950845.
^ “Heart-specific localization of emerin: new insights into Emery-Dreifuss muscular dystrophy”. Human Molecular Genetics 6 (13): 2257–64. (December 1997). doi:10.1093/hmg/6.13.2257. PMID 9361031.
^ “The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus”. The EMBO Journal 25 (14): 3275–85. (July 2006). doi:10.1038/sj.emboj.7601230. PMC 1523183. PMID 16858403.
^ “Identification of the LIM protein FHL2 as a coactivator of beta-catenin”. The Journal of Biological Chemistry 278 (7): 5188–94. (February 2003). doi:10.1074/jbc.M207216200. PMID 12466281.
^ “DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability”. Molecular and Cellular Biology 19 (6): 4414–22. (June 1999). doi:10.1128/mcb.19.6.4414. PMC 104400. PMID 10330181.
^ “c-erbB-2 gene product directly associates with beta-catenin and plakoglobin”. Biochemical and Biophysical Research Communications 208 (3): 1067–72. (March 1995). doi:10.1006/bbrc.1995.1443. PMID 7702605.
^ ^a ^b “Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis”. Molecular and Cellular Biology 25 (4): 1475–88. (February 2005). doi:10.1128/MCB.25.4.1475-1488.2005. PMC 548008. PMID 15684397.
^ “A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway”. Molecular and Cellular Biology 23 (11): 3936–50. (June 2003). doi:10.1128/MCB.23.11.3936-3950.2003. PMC 155208. PMID 12748295.
^ “Functional interaction of beta-catenin with the transcription factor LEF-1”. Nature 382 (6592): 638–42. (August 1996). Bibcode: 1996Natur.382..638B. doi:10.1038/382638a0. PMID 8757136.
^ “Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways”. Proceedings of the National Academy of Sciences of the United States of America 97 (15): 8358–63. (July 2000). Bibcode: 2000PNAS...97.8358L. doi:10.1073/pnas.150152697. PMC 26952. PMID 10890911.
^ “Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion”. The Journal of Biological Chemistry 272 (19): 12492–4. (May 1997). doi:10.1074/jbc.272.19.12492. PMID 9139698.
^ “Interleukin-7 induces MUC1”. Cancer Biology & Therapy 2 (2): 194–5. (2003). doi:10.4161/cbt.2.2.351. PMID 12750562.
^ “MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion”. Oncogene 22 (9): 1324–32. (March 2003). doi:10.1038/sj.onc.1206291. PMID 12618757.
^ “The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin”. The Journal of Biological Chemistry 276 (9): 6061–4. (March 2001). doi:10.1074/jbc.C000754200. PMID 11152665.
^ “Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling”. The Journal of Biological Chemistry 277 (20): 17616–22. (May 2002). doi:10.1074/jbc.M200436200. PMID 11877440.
^ “The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin”. The Journal of Biological Chemistry 276 (38): 35239–42. (September 2001). doi:10.1074/jbc.C100359200. PMID 11483589.
^ “T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors”. Molecular and Cellular Biology 23 (15): 5366–75. (August 2003). doi:10.1128/MCB.23.15.5366-5375.2003. PMC 165725. PMID 12861022.
^ “Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad”. Molecular Endocrinology 17 (4): 507–19. (April 2003). doi:10.1210/me.2002-0362. PMID 12554773.
^ “PCAF acetylates {beta}-catenin and improves its stability”. Molecular Biology of the Cell 20 (1): 419–27. (January 2009). doi:10.1091/mbc.E08-08-0792. PMC 2613091. PMID 18987336.
^ “One hit, two outcomes for VHL-mediated tumorigenesis”. Nature Cell Biology 10 (10): 1127–8. (October 2008). doi:10.1038/ncb1008-1127. PMID 18830218.
^ “The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin”. Molecular Biology of the Cell 14 (6): 2520–9. (June 2003). doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.
^ “Cellular redistribution of protein tyrosine phosphatases LAR and PTPsigma by inducible proteolytic processing”. The Journal of Cell Biology 138 (3): 681–96. (August 1997). doi:10.1083/jcb.138.3.681. PMC 2141638. PMID 9245795.
^ “Association of human protein-tyrosine phosphatase kappa with members of the armadillo family”. The Journal of Biological Chemistry 271 (28): 16712–9. (July 1996). doi:10.1074/jbc.271.28.16712. PMID 8663237.
^ “Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)”. Brain Research 1116 (1): 50–7. (October 2006). doi:10.1016/j.brainres.2006.07.122. PMID 16973135.
^ “Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells”. Biochemical and Biophysical Research Communications 231 (1): 77–81. (February 1997). doi:10.1006/bbrc.1997.6004. PMID 9070223.
^ “Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin”. Biochemistry 41 (52): 15854–60. (December 2002). doi:10.1021/bi026095u. PMID 12501215.
^ “Structural basis of interaction between protein tyrosine phosphatase PCP-2 and beta-catenin”. Science in China Series C: Life Sciences 48 (2): 163–7. (April 2005). doi:10.1007/bf02879669. PMID 15986889.
^ “Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation”. The Journal of Biological Chemistry 273 (51): 33909–14. (December 1998). doi:10.1074/jbc.273.51.33909. PMID 9852041.
^ “Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway”. The Journal of Neuroscience 19 (11): 4229–37. (June 1999). doi:10.1523/JNEUROSCI.19-11-04229.1999. PMC 6782616. PMID 10341227.
^ “Direct association of presenilin-1 with beta-catenin”. FEBS Letters 433 (1–2): 73–7. (August 1998). doi:10.1016/S0014-5793(98)00886-2. PMID 9738936.
^ “Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling”. EMBO Reports 12 (1): 43–9. (January 2011). doi:10.1038/embor.2010.185. PMC 3024124. PMID 21132015.
^ “Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein”. Proceedings of the National Academy of Sciences of the United States of America 95 (25): 14787–92. (December 1998). Bibcode: 1998PNAS...9514787B. doi:10.1073/pnas.95.25.14787. PMC 24527. PMID 9843967.
^ “The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation”. The EMBO Journal 20 (17): 4935–43. (September 2001). doi:10.1093/emboj/20.17.4935. PMC 125268. PMID 11532957.
^ “The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin”. Genes to Cells 4 (12): 757–67. (December 1999). doi:10.1046/j.1365-2443.1999.00297.x. PMID 10620020.
^ “Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro”. Experimental Cell Research 237 (2): 347–56. (December 1997). doi:10.1006/excr.1997.3799. PMID 9434630.
^ “Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin”. American Journal of Physiology. Lung Cellular and Molecular Physiology 282 (6): L1330–8. (June 2002). doi:10.1152/ajplung.00329.2001. PMID 12003790.
^ “Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development”. Developmental Dynamics 225 (1): 1–13. (September 2002). doi:10.1002/dvdy.10131. PMID 12203715.

「β-カテニン」の続きの解説一覧

このページでは「ウィキペディア」からβ-カテニンを検索した結果を表示しています。
Weblioに収録されているすべての辞書からβ-カテニンを検索する場合は、下記のリンクをクリックしてください。

全ての辞書からβ-カテニンを検索

β-カテニンのページへのリンク

β-カテニンとは？わかりやすく解説

β-カテニン

「β-カテニン」の関連用語

β-カテニンとは？ わかりやすく解説

β-カテニン

急上昇のことば

「β-カテニン」の関連用語

β-カテニンとは？わかりやすく解説