ARNTL
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/06/05 03:56 UTC 版)
アリル炭化水素受容体核移行因子様タンパク質1(Aryl hydrocarbon receptor nuclear translocator like 1)はヒトのARNTL遺伝子にコードされたタンパク質である。ARNTLはBMAL1、MOP3とも呼ばれる。（あまり一般的ではないが、BHLHE5, BMAL, BMAL1C, JAP3, PASD3, TICという呼び名も用いられる）
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055116 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “ARNTL aryl hydrocarbon receptor nuclear translocator-like [ Homo sapiens (human) ]”. National Center for Biotechnology Information. 2018年1月31日閲覧。
- ^ “The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus”. Diabetes Research and Clinical Practice 99 (2): 151–7. (February 2013). doi:10.1016/j.diabres.2012.10.015. PMID 23206673.
- ^ “Clock genes in hypertension: novel insights from rodent models”. Blood Pressure Monitoring 19 (5): 249–54. (October 2014). doi:10.1097/MBP.0000000000000060. PMC 4159427. PMID 25025868.
- ^ “ARNTL Gene”. Gene Cards: The Human Genome Compendium. Lifemap Sciences, Inc.. 2018年1月31日閲覧。
- ^ “Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism”. Molecular and Cellular Biology 30 (24): 5636–48. (December 2010). doi:10.1128/MCB.00781-10. PMC 3004277. PMID 20937769.
- ^ “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. The Journal of Biological Chemistry 272 (13): 8581–93. (March 1997). doi:10.1074/jbc.272.13.8581. PMID 9079689.
- ^ “cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage”. Biochemical and Biophysical Research Communications 233 (1): 258–64. (April 1997). doi:10.1006/bbrc.1997.6371. PMID 9144434.
- ^ “A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock”. Cell 96 (1): 57–68. (January 1999). doi:10.1016/S0092-8674(00)80959-9. PMID 9989497.
- ^ “Mop3 is an essential component of the master circadian pacemaker in mammals”. Cell 103 (7): 1009–17. (December 2000). doi:10.1016/S0092-8674(00)00205-1. PMC 3779439. PMID 11163178.
- ^ “Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex”. Science 337 (6091): 189–94. (July 2012). Bibcode: 2012Sci...337..189H. doi:10.1126/science.1222804. PMC 3694778. PMID 22653727.
- ^ “Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA”. Cell Research 23 (2): 213–24. (February 2013). doi:10.1038/cr.2012.170. PMC 3567813. PMID 23229515.
- ^ “Circadian rhythms, the molecular clock, and skeletal muscle”. Journal of Biological Rhythms 30 (2): 84–94. (April 2015). doi:10.1177/0748730414561638. PMC 4470613. PMID 25512305.
- ^ “Circadian rhythms - from genes to physiology and disease”. Swiss Medical Weekly 144: w13984. (2014). doi:10.4414/smw.2014.13984. PMID 25058693.
- ^ “The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins”. Journal of Biological Rhythms 29 (2): 110–8. (April 2014). doi:10.1177/0748730414520663. PMC 4131702. PMID 24682205.
- ^ “SIRT1 regulates circadian clock gene expression through PER2 deacetylation”. Cell 134 (2): 317–28. (July 2008). doi:10.1016/j.cell.2008.06.050. PMID 18662546.
- ^ “A transcription factor response element for gene expression during circadian night”. Nature 418 (6897): 534–9. (August 2002). Bibcode: 2002Natur.418..534U. doi:10.1038/nature00906. PMID 12152080.
- ^ “The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1”. Nature Structural & Molecular Biology 12 (5): 441–8. (May 2005). doi:10.1038/nsmb925. PMID 15821743.
- ^ “Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors”. Journal of Biological Rhythms 20 (5): 391–403. (October 2005). doi:10.1177/0748730405277232. PMID 16267379.
- ^ “System-level identification of transcriptional circuits underlying mammalian circadian clocks”. Nature Genetics 37 (2): 187–92. (February 2005). doi:10.1038/ng1504. PMID 15665827.
- ^ Takahashi, Joseph S., ed (February 2008). “Redundant function of REV-ERBα and β and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms”. PLoS Genetics 4 (2): e1000023. doi:10.1371/journal.pgen.1000023. PMC 2265523. PMID 18454201.
- ^ “CLOCK-mediated acetylation of BMAL1 controls circadian function”. Nature 450 (7172): 1086–90. (December 2007). Bibcode: 2007Natur.450.1086H. doi:10.1038/nature06394. PMID 18075593.
- ^ “Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex”. Molecular and Cellular Biology 28 (19): 6056–65. (October 2008). doi:10.1128/MCB.00583-08. PMC 2546997. PMID 18644859.
- ^ “The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon”. The Journal of Biological Chemistry 277 (19): 17248–54. (May 2002). doi:10.1074/jbc.m111466200. PMC 1513548. PMID 11875063.
- ^ “Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1”. The Journal of Biological Chemistry 277 (1): 267–71. (January 2002). doi:10.1074/jbc.m107850200. PMID 11687575.
- ^ “CK2alpha phosphorylates BMAL1 to regulate the mammalian clock”. Nature Structural & Molecular Biology 16 (4): 446–8. (April 2009). doi:10.1038/nsmb.1578. PMID 19330005.
- ^ “Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation”. PLoS One 5 (1): e8561. (January 2010). Bibcode: 2010PLoSO...5.8561S. doi:10.1371/journal.pone.0008561. PMID 20049328.
- ^ “Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes”. Proceedings of the National Academy of Sciences of the United States of America 104 (36): 14412–7. (September 2007). Bibcode: 2007PNAS..10414412W. doi:10.1073/pnas.0703247104. PMC 1958818. PMID 17728404.
- ^ “BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis”. PLoS Biology 2 (11): e377. (November 2004). doi:10.1371/journal.pbio.0020377. PMC 524471. PMID 15523558.
- ^ “Obesity and metabolic syndrome in circadian Clock mutant mice”. Science 308 (5724): 1043–5. (May 2005). Bibcode: 2005Sci...308.1043T. doi:10.1126/science.1108750. PMC 3764501. PMID 15845877.
- ^ “Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes”. Nature 466 (7306): 627–31. (July 2010). Bibcode: 2010Natur.466..627M. doi:10.1038/nature09253. PMC 2920067. PMID 20562852.
- ^ “Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6”. Experimental & Molecular Medicine 44 (11): 642–52. (November 2012). doi:10.3858/emm.2012.44.11.073. PMC 3509181. PMID 22913986.
- ^ “Assessment of circadian function in fibroblasts of patients with bipolar disorder”. Molecular Psychiatry 14 (2): 143–55. (February 2009). doi:10.1038/mp.2008.10. PMID 18301395.
- ^ “Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression”. Annals of Medicine 39 (3): 229–38. (2007). doi:10.1080/07853890701278795. PMID 17457720.
- ^ “A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway”. PLoS One 4 (3): e4798. (2009). Bibcode: 2009PLoSO...4.4798M. doi:10.1371/journal.pone.0004798. PMC 2653142. PMID 19277210.
- ^ “Circadian rhythms and reproduction”. Reproduction 132 (3): 379–92. (September 2006). doi:10.1530/rep.1.00614. PMID 16940279.
- ^ “A role of the circadian system and circadian proteins in aging”. Ageing Research Reviews 6 (1): 12–27. (May 2007). doi:10.1016/j.arr.2007.02.003. PMID 17369106.
- ^ “Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus”. Genesis 41 (3): 122–32. (March 2005). doi:10.1002/gene.20102. PMID 15739187.
- ^ “Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2”. Current Biology 20 (4): 316–21. (February 2010). doi:10.1016/j.cub.2009.12.034. PMC 2907674. PMID 20153195.
- ^ “Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression”. Molecular and Cellular Biology 24 (2): 608–16. (January 2004). doi:10.1128/MCB.24.2.608-616.2004. PMC 343817. PMID 14701734.
- ^ “Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock”. Cell 105 (7): 877–89. (June 2001). doi:10.1016/S0092-8674(01)00401-9. PMID 11439184.
- ^ “Transactivation mechanisms of mouse clock transcription factors, mClock and mArnt3”. Genes to Cells 5 (9): 739–47. (September 2000). doi:10.1046/j.1365-2443.2000.00363.x. PMID 10971655.
- ^ “Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus”. Nature Structural & Molecular Biology 22 (6): 476–84. (June 2015). doi:10.1038/nsmb.3018. PMC 4456216. PMID 25961797.
- ^ “The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors”. Proceedings of the National Academy of Sciences of the United States of America 95 (10): 5474–9. (May 1998). Bibcode: 1998PNAS...95.5474H. doi:10.1073/pnas.95.10.5474. PMC 20401. PMID 9576906.
- ^ “The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors”. The Journal of Neuroscience 20 (13): RC83. (July 2000). PMID 10864977.
[続きの解説]
「ARNTL」の続きの解説一覧
- 1 ARNTLとは
- 2 ARNTLの概要
- 3 歴史
- 4 ノックアウト研究
- 5 外部リンク
- ARNTLのページへのリンク
