The Tuberculin Protein TBU-Bovine (523)
Abstract
AS has been increasingly emphasized lately, the fundamental problem of protein structure is to explain the ezisterice of very large but chemically and physically well-defined molecules. It is evident that any two-dimensional pattern of amino-acid residues will either be ineapabl of folding to form a closed cage-like structure, or will form such a structure only in certnin ways which cortespond to definite numbers of residues. Irrespective of the particular nature of the characteristic protein fabric, the idea of closed structures (such as n cage2 or torus or surfaces of higher connectivity) has therefore been offered as an explanation of the existence of these protein megamolecules.
- Publication:
-
Nature
- Pub Date:
- July 1939
- DOI:
- 10.1038/144077a0
- Bibcode:
- 1939Natur.144...77W