Abstract
Historically, both bone marrow depression and leukemogenesis have been associated with exposure to benzene in the industrial setting. As early as 1897, Santesson (1) described chronic benzene poisoning in Sweden and, around the time of World War I, Selling (2), at Johns Hopkins, described benzene-induced aplastic anemia in both man and animals. Impaired immunological mechanisms in benzene-treated animals were first reported before World War I (3–8). Prior to the development of modern industrial hygiene, the uncontrolled use of benzene in industry expanded despite the growing appreciation of the dangers of working in an atmosphere laden with this highly volatile solvent.
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Snyder, R., Sammett, D., Witmer, C., Kocsis, J.J. (1982). An Overview of the Problem of Benzene Toxicity and Some Recent Data on the Relationship of Benzene Metabolism to Benzene Toxicity. In: Tice, R.R., Costa, D.L., Schaich, K.M. (eds) Genotoxic Effects of Airborne Agents. Environmental Science Research, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3455-2_18
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DOI: https://doi.org/10.1007/978-1-4613-3455-2_18
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