食物アレルゲンの吸収機構の解明と食物アレルギーの発症に関する研究

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  • 横大路 智治
    広島大学大学院 医歯薬保健学研究院　病態解析治療学研究室

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タイトル別名
  • Intestinal Absorption of Food Allergens and Development of Food Allergic Symptoms
  • ショクモツ アレルゲン ノ キュウシュウ キコウ ノ カイメイ ト ショクモツ アレルギー ノ ハッショウ ニ カンスル ケンキュウ

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抄録

Food–dependent exercise-induced anaphylaxis (FDEIA) is a peculiar form of food allergy, which is induced by physical exercise following the ingestion of causative food products. Patients with FDEIA typically exhibit generalized urticaria, dyspnea and anaphylaxis induced by the type–I allergic reaction. In addition to exercise, intake of nonsteroidal anti–inflammatory drugs, especially aspirin, is another well–documented trigger for FDEIA symptoms. The pathogenesis of aspirin–exacerbated FDEIA symptoms remains unclear. However, increases in the absorption of allergens via the intestinal tract and/or activation of inflammatory cells by aspirin are considered to be the underlying mechanisms for it. Recently, we found that food allergens including lysozyme and ovalbumin were absorbed via paracellular and transcytotic pathways, and aspirin facilitated the intestinal absorptions of these allergens via the paracellular pathway, resulting in the development and exacerbation of food–allergic symptoms. This review summarizes the pathogenesis of aspirin–induced FDEIA symptoms from the viewpoint of intestinal absorption pathway(s) of food allergens and the effect of aspirin on their absorptions.

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  • 膜

    膜 40 (5), 284-290, 2015

    日本膜学会

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