Skip to main content

Chemical Warfare Agents: Estimating Oral Reference Doses

  • Chapter
  • First Online:
Reviews of Environmental Contamination and Toxicology

Abstract

The FY 1993 Defense Authorization Act [Public Law (PL) 102–484, Sect. 176] directed the U.S. Department of the Army (DA) 1 to examine the scale of effort and consider plans needed to safely dispose of nonstockpile chemical materiel (NSCM), previously identified as an area of national concern in House Appropriations Report 101–822 from the FY 1991 Defense Appropriations Act. Non-stockpile chemical materiel is defined in the Appropriations Report as “… lethal wastes from past disposal efforts, unserviceable munitions, chemically contaminated containers, chemical production facilities, subsequently located chemical munitions, sites known to contain significant concentrations of buried chemical weapons and waste, and binary weapons and components.” Items considered NSCM are further characterized as chemical materiel outside of the U.S. retaliatory stockpile of lethal chemical agents and munitions (described more fully in Carnes and Watson 1989; DA 1988).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Abbrecht PH, Kyle RR, Bryant HJ (1989) Nebulized atropine for treatment of organophosphate toxicity. USAMRDC Med Def Biocsi Rev, pp 201–205. (Cited in Somani et al. 1992.)

    Google Scholar 

  • ACGIH (1991) Cyanogen chloride. In: Documentation of the Threshold Limit Values and Biological Exposure Indices, 5th Ed. American Conference of Governmental Industrial Hygienists, Cincinnati, OH, pp 353–354.

    Google Scholar 

  • Albuquerque EX, Deshpande SS, Kawabuchi M, Aracava Y, Idriss M, Rickett DL, Boyne AF (1985) Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning. Fund Appl Toxicol 5:S182–S203.

    Article  CAS  Google Scholar 

  • Aldridge WN (1951) The conversion of cyanogen chloride to cyanide in the presence of blood proteins and sulphydryl compounds. Biochem J 48:271–276.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aldridge WN, Evans CL (1946) The physiological effects and fate of cyanogen chloride. Q J Exp Physiol 33:241–266.

    Article  CAS  Google Scholar 

  • Anderson DR, Harris LW, Lennox WJ (1989) Subacute vs. acute physostigmine pretreatment against soman poisoning. USAMRDC Med Def Biocsi Rev, pp 511–514. (Cited in Somani et al. 1992.)

    Google Scholar 

  • APHA (1975) Standard Methods for the Examination of Water and Wastewater, 14th Ed. American Public Health Association, Washington, DC.

    Google Scholar 

  • Armstrong GC, Wells HB, Wilkes AE, Moulton CH (1928) Comparative test with mustard gas (HS) lewisite (M-1), methyldicloroarsine (MD) and methyldifluorarsine (MD2) in 75 mm shell fired statically in collaboration with chemical division. EAMRD 95. U.S. Department of the Army, Medical Research Division, Edgewood Arsenal, MD.

    Google Scholar 

  • Atkinson R (1987) A structure-activity relationship for the estimation of rate constants for the gas-phase reactions of OH radicals with organic compounds. Int J Chem Kinet 19:799–828.

    Article  CAS  Google Scholar 

  • ATSDR (1992) Toxicological profile for mustard gas. TP-91/22. Agency for Toxic Substances and Disease Registry, Atlanta, GA.

    Google Scholar 

  • ATSDR (1995) Toxicological profile for cyanide. Draft for public comment: update. Research Triangle Institute, contract No. 205–93–0606. Prepared for Agency for Toxic Substances and Disease Registry, U.S. Public Health Service, Washington, DC.

    Google Scholar 

  • Auerbach C, Robson JM (1946) Letter to the editor: chemical production of mutations. Nature (Lond) 157:302.

    Article  CAS  Google Scholar 

  • Auerbach C, Robson JM (1947a) The production of mutations by chemical substances. Proc R Soc Edinb 62B:271–283.

    CAS  Google Scholar 

  • Auerbach C, Robson JM (1947b) Tests of chemical substances for mutagenic action. Proc Soc Edinb 62B:284–291.

    CAS  Google Scholar 

  • Augustinsson K-B (1959) Electrophoresis studies on blood plasma esterases. I. Mammalian plasmata. Acta Chem Scand 13:571–592.

    Article  CAS  Google Scholar 

  • Azizi F, Keshavarz A, Roshanzamir F, Nafarabadi M (1995) Reproductive function in men following exposure to chemical warfare with sulfur mustard. Med War 11:34–44.

    Article  CAS  PubMed  Google Scholar 

  • Bailey PL, Bishop E (1970) The hydrolysis of cyanogen chloride. Proc Soc Anal Chem 7:150–152.

    Google Scholar 

  • Baker DJ, Sedgwick EM (1996) Single fibre electromyographic changes in man after organophosphate exposure. Hum Exp Toxicol 15:369–375.

    Article  CAS  PubMed  Google Scholar 

  • Bakry NM, El-Rashidy AH, Eldefrawi AT, Eldefrawi ME (1988) Direct action of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors. J Biochem Toxicol 3:235–259.

    Article  CAS  PubMed  Google Scholar 

  • Ballantyne B (1987) Toxicology of cyanides. In: Marrs TS, Ballantyne B (eds) Clinical and Experimental Toxicology of Cyanides. Wright, Bristol, UK, pp 41–126.

    Google Scholar 

  • Barnes JM (1954) Organo-phosphorus insecticides: the toxic action of organo-phospho-rus insecticides in mammals. Chem Ind, 5:478–480.

    Google Scholar 

  • Bauer VE, Epstein J, Flannery MC (1949) The effect of oral ingestion of GB in water on rats. Medical Division Report 186. U.S. Department of the Army, Army Chemical Center, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Bauer VE, Lindsten DC, Epstein J (1955) Field purification of water containing CW agents with Corps of Engineers mobile water purification unit. MLRR No. 344. Chemical Corps Medical Laboratory, Army Chemical Center, Aberdeen Proving Ground, MD. (Cited in Rosenblatt et al. 1975.)

    Google Scholar 

  • Baze WB (1993) Soman-induced morphological changes: an overview in the non-human primate. J Appl Toxicol 13:173–177.

    Article  CAS  PubMed  Google Scholar 

  • Beaudry WT, Bossle PC, Harvey SP, Kolakowski JE, Procell LR, Rohrbaugh DK, Sor-rick DC, Stroup AN, Szafraniec LL, Yang YC (1995) Neutralization/biodegradation of HD. In: Watson AP, Kistner SL, (eds) Analytical methods for environmental sampling of chemical warfare agents and their degradation products. ORNL/M-4315, Oak Ridge National Laboratory, Oak Ridge, TN.

    Google Scholar 

  • Beebe GW (1960) Lung cancer in World War I veterans: possible relation to mustard gas injury and 1918 influenza epidemic. J Natl Cancer Inst 25:1231–1252.

    CAS  PubMed  Google Scholar 

  • Blick DW, Weatherby FR Jr, Brown GC, Murphy MR (1994) Behavioral toxicity of anticholinesterases in primates: effects of daily repeated exposure. Pharmacol Biochem Behav 48:643–649.

    Article  CAS  PubMed  Google Scholar 

  • Bonderman RP, Bonderman DP (1971) Atypical and inhibited human serum pseudocho-linesterase: a titrimetric method for differentiation. Arch Environ Health 22:578–581.

    Article  CAS  PubMed  Google Scholar 

  • Bowers MB Jr, Goodman E, Sim VM (1964) Some behavioral changes in man following anticholinesterase administration. J Neurol Ment Dis 138:383–389.

    Article  Google Scholar 

  • Boyland E, Horning ES (1949) The induction of tumors with nitrogen mustards. Br J Cancer 3:118–123

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Britton KB, Grant CL (1988) Prediction of octanol-water partition coefficients of organophosphates. Evaluation of structure-function relationships. Special Rep 88–11. U.S. Department of the Army, Corps of Engineers Cold Regions Research and Engineering Laboratory, Hanover, NF.

    Google Scholar 

  • Broderius SJ, Smith LL Jr, Lind DT (1977) Relative toxicity of free cyanide and dissolved sulfide forms to the fathead minnow (Pimephales promelas). J Fish Res Board Can 34:2323–2332. (Cited in Kononen 1988).

    Article  CAS  Google Scholar 

  • Bucci TJ, Parker RM (1992) Toxicity studies on agents GB and GD (phase II), 90 day subchronic study of GB (sarin type II) in CD-rats. Final report (DTIC: AD-A248618). Prepared for U.S. Department of the Army, Biomedical Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Bucci TJ, Parker RM, Crowell JA, Thurman JD, Gosnell PA (1991) Toxicity studies on agents GB and GD (phase II): 90 day subchronic study of GB (sarin type I) in CD-rats. FDA 224–85–0007 (DTIC: AD-A248617). Prepared for the U.S. Department of the Army, Biomedical Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Bucci TJ, Parker RM, Crowell JA, Thurman JD, Gosnell PA (1992a) Toxicity studies on agent GA (phase II): 90 day subchronic study of GA (tabun) in CD rats. Final report (DTIC: AD-A258020). Prepared for the U.S. Department of the Army, Biomedical Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Bucci TJ, Parker RM, Gosnell PA (1992b) Delayed neuropathy study of sarin, type II, in SPF white leghorn chickens. NTCR Rep 478 and 479. National Center for Toxicological Research, Jefferson, AK. Prepared for U.S. Department of the Army, Biomedical Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Bucci TJ, Parker RM, Gosnell PA (1992c) Toxicity studies on agents GB and GD (phase II): 90 day subchronic study of GD (soman) in CD-rats. FDA 224–85–0007. Prepared for the U.S. Department of the Army, Biomedical Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Bucci TJ, Parker RM, Gosnell PA (1992d) Toxicity studies on agents GB and GD (phase II): delayed neuropathy study of soman in SPF white leghorn chickens. Final report. Prepared for the U.S. Department of the Army, Biomedical Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Bucci TJ, Fikes JD, Parker RM, Denny KH, Dacre JC (1993a) Developmental toxicity study (segment II: teratology) of tabun in CD rats and in New Zealand white rabbits. E515 and E516. National Center for Toxicological Research. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Bucci TJ, Parker RM, Dacre JC, Denny KH (1993b) Dominant lethal study of lewisite in male rats. NCTR Tech Rep, Experiment No. 6579. National Center for Toxicological Research, Jefferson, AR.

    Google Scholar 

  • Budavari S, O’Neil MJ, Smith A, Heckelman PE (eds) (1989) The Merck Index, I lth Ed. Merck, Rahway, NJ.

    Google Scholar 

  • Budavari S, O’Neil MJ, Smith A (eds) (1996) The Merck Index, 12th Ed. Merck, Rahway, NJ, p 453.

    Google Scholar 

  • Burchfiel JL, Duffy FH (1982) Organophosphate neurotoxicity: chronic effects of sarin on the electroencephalogram of monkey and man. Neurobehav Toxicol Teratol 4: 767–778.

    CAS  PubMed  Google Scholar 

  • Buswell AM, Price CC, Prosser CL, Bennett GW, von Limbach B, James M (1944) The effect of certain chemical warfare agents in water on aquatic organisms. Rep OSRD 3589. National Defense Research Committee, Office of Scientific Research and Development, Washington, DC.

    Google Scholar 

  • Calabrese EJ (1991) Cyanide toxicity. In: Principles of Animal Extrapolation. Lewis Publishers, Chelsea, MI, pp 278–281.

    Google Scholar 

  • Callaway S, Davies DR, Rutland JP (1951) Blood cholinesterase levels and range of personal variation in a healthy adult population. Br Med J 2:812–816.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cameron GR, Carleton HM, Short RHD (1946) Pathological changes induced by lewisite and allied compounds. J Pathol Bacteriol 58:411–422.

    Article  CAS  PubMed  Google Scholar 

  • Capizzi RL, Smith WJ, Field R, Papirmeister B (1973) A host-mediated assay for chemical mutagens using L5178Y/Asn murine leukemia. Mutat Res 21:6.

    Article  Google Scholar 

  • Carmelo S (1955) New contributions to the study of subacute-chronic hydrocyanic acid intoxication in man. Rass Med Int 24:254–271. (Cited in USEPA 1985.)

    Google Scholar 

  • Carnes SA, Watson AP (1989) Disposing of the U.S. chemical weapons stockpile: an approaching reality. JAMA 262:653–659.

    Article  CAS  PubMed  Google Scholar 

  • Carnes SA, Boyette JA, Kornegay FC, Breck JE, Schweitzer M, Coleman PR, Sigal LL, Griffin GD, Thomas GA, Hillsman EL, Tolbert VR, Johnson PE (1986) Preliminary assessment of the health and environmental impacts of incinerating M55 rockets stored at Pine Bluff Arsenal, Lexington-Blue Grass Depot Activity, and/or Anniston Army Depot at Pine Bluff Arsenal. ORNL-6197. Oak Ridge National Laboratory, Oak Ridge, TN.

    Google Scholar 

  • Case RAM, Lea AJ (1955) Mustard gas poisoning, chronic bronchitis and lung cancer. An investigation into the possibility that poisoning by mustard gas in the 1914–1918 war might be a factor in the production of neoplasia. Br J Prey Med 9:1914–1918.

    CAS  Google Scholar 

  • Chen S-M, Chi M-G (1986) Direct effect of VX and soman on nicotinic receptors. Acta Pharmacol Sin 7:401–406.

    CAS  Google Scholar 

  • Choudhury H (1996) National Center for Environmental Assessment, U.S. Environmental Protection Agency, Cincinnati, OH. Personal communication to DM Opresko, Oak Ridge National Laboratory, Oak Ridge, TN, July 1996.

    Google Scholar 

  • Churchill L, Pazdernik TL, Jackson JL, Nelson SR, Samson F, McDonough JH, McLeod CG (1985) Soman-induced brain lesions demonstrated by muscarinic receptor autoradiography. Neurotoxicology 6:81–90.

    CAS  PubMed  Google Scholar 

  • Cicmanec JL, Dourson ML, Hertzberg RC (1996) Noncancer risk assessment: present and emerging issues. In: Fan AM, Chang LW (eds) Toxicology and Risk Assessment: Principles, Methods, and Applications. Marcel Dekker, New York, pp 293–310.

    Google Scholar 

  • Clark DN (1989) Review of reactions of chemical agents in water. DTIC: AD-A213 287. Defense Technical Information Center, Alexandria, VA.

    Google Scholar 

  • Cohen BS, Oberst FW, Crook JW, Harris C (1954) Effect of repeated exposures of GB vapor on erythrocyte and brain cholinesterase in rats. Medical Laboratories Research Rep 297. Army Chemical Center, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Cohen EM, Christen PJ, Mobach E (1971) The inactivation by oximes of sann and soman in plasma from various species. I. The influence of diacetylmonoxime on the hydrolysis of sann. JA Cohen Memorial Issue. North-Holland, Amsterdam, pp 113–131.

    Google Scholar 

  • Conklin JW, Upton AC, Christenberry KW (1965) Further observations on late somatic effects of radiomimetic chemicals and X-rays in mice. Cancer Res 25:20–28.

    CAS  PubMed  Google Scholar 

  • Crathorn AR, Roberts JJ (1965) Reactions of cultured mammalian cells of varying radio-sensitivity with the radiomimetic alkylating agent mustard gas. Prog Biochem Pharmacol 1:320–326.

    CAS  Google Scholar 

  • Crathorn AR, Roberts JJ (1966) Mechanism of the cytotoxic action of alkylating agents in mammalian cells and evidence for the removal of alkylated groups from deoxyribonucleic acid. Nature (Lond) 211:150–153.

    Article  CAS  Google Scholar 

  • Crook JW, Hott P, Owens EJ, Cummings EG, Farrand RL, Cooper AE (1983) The effects of subacute exposures of the mouse, rat, guinea pig, and rabbit to low-level VX concentrations. ARCSL-TR-82038 (DTIC: AD BO86567L). Chemical Systems Laboratory, U.S. Department of the Army, Armament Research and Development Command, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Crowell JA, Parker RM, Bucci TJ, Dacre JC (1989) Neuropathy target esterase in hens after sann and soman. J Biochem Toxicol 4:15–20.

    Article  CAS  PubMed  Google Scholar 

  • D’Agostino PA, Provost LR (1992) Determination of chemical warfare agents, their hydrolysis products and related compounds in soil. J Chromatogr 589:287–294.

    Article  Google Scholar 

  • DA (Department of the Army) (1974) Chemical agent data sheets, vol 1. Edgewood Arsenal Special Report, EO-SR-74001. U.S. Department of the Army, Edgewood Arsenal, Aberdeen Proving Ground, MD.

    Google Scholar 

  • DA (1987) Safety regulations for chemical agents H, HD, HT, GB and VX. AMC-R 385–131. U.S. Department of the Army, Material Command, Alexandria, VA.

    Google Scholar 

  • DA (1988) Final programmatic environmental impact statement for the chemical stockpile disposal program. U.S. Department of the Army, Office of the Program Executive Officer, Program Manager for Chemical Demilitarization, Aberdeen Proving Ground, MD.

    Google Scholar 

  • DA (1990a) Occupational health guidelines for evaluation and control of occupational exposure to nerve agents GA, GB, GD and VX. DA Pam 40–8. U.S. Department of the Army, Headquarters, Washington, DC.

    Google Scholar 

  • DA (1990b) Material safety data sheets: HT. U.S. Department of the Army, Edgewood Research, Development and Engineering Center, Aberdeen Proving Ground, MD.

    Google Scholar 

  • DA (1992a) Material safety data sheets: HD and THD. U.S. Department of the Army, Edgewood Research, Development and Engineering Center, Aberdeen Proving Ground, MD.

    Google Scholar 

  • DA (1992b) Material safety data sheets: lethal nerve agents GA, GB, VX. U.S. Department of the Army, Edgewood Research, Development and Engineering Center, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Dacre JC (1984) Toxicology of some anticholinesterases used as chemical warfare agents—a review. In: Brzin M, Barnard EA, Sket D (eds) Cholinesterases: Fundamental and Applied Aspects. de Gruyter, New York, pp 415–426.

    Chapter  Google Scholar 

  • Dahl H, Glund B, Vangstad P, Norn M (1985) Eye lesions induced by mustard gas. Acta Ophthalmol 63(suppl 173):30–31.

    Google Scholar 

  • Danforth CH, Cater E (1954) Nitrogen mustard as a teratogenic agent in the mouse. Proc Soc Exp Biol Med 86:705–707.

    Article  CAS  PubMed  Google Scholar 

  • Daniels JL (1990) Lewisite. pp. 6–1 to 6–1 In: Daniels JL (ed) Evaluation of military field-water quality, chapter 6, vol 4, part 2. Interim standards for selected threat agents and risks from exceeding these standards. UCRL-21008. Lawrence Livermore National Laboratory, Univ. of California, Livermore CA.

    Google Scholar 

  • Daughton CG, Cook AM, Alexander M (1979) Bacterial conversion of alkylphosphonates to natural products via carbon-phosphorus bond cleavage. J Agric Food Chem 27:1375–1382.

    Article  CAS  Google Scholar 

  • Davies DR, Holland P (1972) Effect of oximes and atropine upon the development of delayed neurotoxic signs in chickens following poisoning by DFP and sarin. Biochem Pharmacol 21:3145–3151.

    Article  CAS  PubMed  Google Scholar 

  • Davies DR, Holland P, Rumens MJ (1960) The relationship between the chemical structure and neurotoxicity of alkyl organophosphorus compounds. Br J Pharmacol 15: 271–278.

    CAS  Google Scholar 

  • De Bruin A (1976) Sulfhydryl groups and glutathione metabolism. In: Biochemical Toxicology of Environmental Agents. Elsevier, New York, pp 910–935.

    Google Scholar 

  • De Flora S (1981) Study of 106 organic and inorganic compounds in the Salmonella/ microsome test. Carcinogenesis (Oxf) 2:282–298.

    Article  Google Scholar 

  • De Flora S, Zanacchi P, Camoirano A, Bennicelli C, Badoleti GC (1984) Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test. Mutat Res 133:161–198.

    Article  PubMed  Google Scholar 

  • deJong LPA, Wolring GZ (1978) Effect of 1-(AR)alkyl-2-hydroxyiminomethyl-pyridinium salts on reactivation and aging of acetylcholinesterase inhibited by ethyl dimethylphosphoramidocyanidate (tabun). Biochem Pharmacol 27:2229–2235.

    Article  CAS  Google Scholar 

  • Denk JR (1975) Effects of GB on mammalian germ cells and reproductive parameters. EB-TR-74087. U.S. Department of the Army, Edgewood Arsenal, Aberdeen Proving Ground, MD.

    Google Scholar 

  • DHHS (1987) Recommendations for protecting the health and safety against potential adverse effects of long-term exposure to low doses of agents: GA, GB, VX, mustard agent (H, HD, T), and lewisite (L). Request for public comment. U.S. Department of Health and Human Services, Centers for Disease Control. Fed Reg 52(245):48458–48461.

    Google Scholar 

  • DHHS (1988) Final recommendations for protecting the health and safety against potential adverse effects of long-term exposure to low doses of agents: GA, GB, VX, mustard agent (H, HD, T), and lewisite (L). U.S. Department of Health and Human Services, Centers for Disease Control. Fed Reg 53(50):8504–8507.

    Google Scholar 

  • Doherty PA, Ferm VH, Smith RP (1982) Congenital malformations induced by infusion of sodium cyanide in the golden hamster. Toxicol Appl Pharmacol 64:456–464.

    Article  CAS  PubMed  Google Scholar 

  • Doull J, Klaassen CD, Amdur MO (eds) (1980) Casarett and Doull’s Toxicology. The Basic Science of Poisons, 2nd Ed. MacMillan, New York.

    Google Scholar 

  • Duffy FH, Burchfiel JL, Bartels PH, Gaon M, Sim VM (1979) Long-term effects of an organophosphate upon the human electroencephalogram. Toxicol Appl Pharmacol 47: 161–176.

    Article  CAS  PubMed  Google Scholar 

  • Dulaney MD, Hoskins B, Ho IK (1985) Studies on low dose sub-acute administration of soman, sann, and tabun in the rat. Acta Pharmacol Toxicol 57:234–241.

    Article  CAS  Google Scholar 

  • Easton DF, Peto J, Doll R (1988) Cancers of the respiratory tract in mustard gas workers. Br J Ind Med 45(10):652–659.

    CAS  PubMed  PubMed Central  Google Scholar 

  • El Ghawabi SH, Gaafar MA, El-Saharti AA, Ahmed SH, Malash KK, Fares R (1975) Chronic cyanide exposure: a clinical, radioisotope and laboratory study. Br J Ind Med 32:215–219.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ellin RI (1981) Anomalies in theories and therapy of intoxication by potent organophosphorus anticholinesterase compounds. Special Publ USABML-SP-81–003 (DTIC: AD A101364). U.S. Department of the Army, Medical Research and Development Command, Biomedical Laboratory, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Epstein J (1956) Nerve gas in public water. Public Health Rep 71:955–962.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Epstein J (1974) Properties of GB in water. J Am Water Works Assoc 66:31–37.

    Article  CAS  Google Scholar 

  • Epstein J, Rosenblatt DH, Gallacio A, McTeague WF (1973) Summary report on a data base for predicting consequences of chemical disposal operations. EASP 1200–12. U.S. Department of the Army, Edgewood Arsenal, MD.

    Google Scholar 

  • Epstein J, Callahan JJ, Bauer VE (1974) The kinetics and mechanisms of hydrolysis of phosphonothiolates in dilute aqueous solution. Phosphorus 4:157–163.

    CAS  Google Scholar 

  • Eto M (1974) Organophosphorus Pesticides: Organic and Biological Chemistry. CRC Press, Cleveland, OH, pp 123–231.

    Google Scholar 

  • Fedoroff BT, Sheffield OS (1962) Chemical agents or chemical warfare agents (CWA). In: Encyclopedia of Explosives and Related Items, vol 2. Picatinny Arsenal, Dover, NJ, pp. C165–C167.

    Google Scholar 

  • Fichet A (1942) Effects of yperite on plants. Bull Mens Soc Linn Lyon 11:147–150. (Cited in Rosenblatt et al. 1975.)

    CAS  Google Scholar 

  • Fleisher JH, Harris LW, Prudhomme C, Bursel J (1963) Effects of ethyl p-nitrophenyl thionobenzene phosphonate (EPN) on the toxicity of isopropyl methyl phosphonofluoridate (GB). J Pharmacol Exp Ther 139:390–396.

    CAS  PubMed  Google Scholar 

  • Flesch JJ, Fair PS (1989) The analysis of cyanogen chloride in drinking water. Proc Water Qual Technol Conf 16:465–474.

    Google Scholar 

  • Flury F, Zernik F (1931) Schädliche Gase [Noxious Gases, Vapors, Mists, Smoke, and Dust Particles]. Springer-Verlag, Berlin, pp 350–354.

    Google Scholar 

  • FOA (1992) A FOA Briefing Book on Chemical Weapons: Threats, Effects and Protection. Försvarets Forskningsanstalt Orienterar OM, No. 16, Sundberg, Sweden.

    Google Scholar 

  • Fonnum F, Stem SH (1981) Factors modifying the toxicity of organophosphorous compounds including soman and sarin. Fundam Appl Toxicol 1:143–147.

    Article  CAS  PubMed  Google Scholar 

  • Fonnum F, Steni SH, Aas P, Johnsen H (1985) Carboxylesterases, importance for detoxification of organophosphorus anticholineserases and trichothecenes. Fundam Appl Toxicol 5:S29–S38.

    Article  CAS  PubMed  Google Scholar 

  • Forsman N, Frostling H, Hertzberg 0, Jansson B, Larsson L, Lundin J, Meyerhöffer A, Persson G, Santesson J, Sörbo B, Östman B (1979) C-weapons (characteristics and defense). USAMIIA-HT-010–79 (DTIC: AD A075722). U.S. Department of the Army, Medical Intelligence and Information Agency, Fort Detrick, MD.

    Google Scholar 

  • Fox M, Scott D (1980) The genetic toxicology of nitrogen and sulfur mustard. Mutat Res 75(2):131–168.

    CAS  Google Scholar 

  • Frakes RA, Sharma RP, Willhite CC, Gomez G (1986) Effect of cyanogenic glycosides and protein content in cassava diets on hamster prenatal development. Fundam Appl Toxicol 7:191–198.

    Article  CAS  PubMed  Google Scholar 

  • Franke S (1982) Textbook of military chemistry, vol 1. USAMIIA-HT-039–82 (DTIC: AD B062913). Defense Technical Information Center, Alexandria, VA.

    Google Scholar 

  • Friedman MA, Staub J (1976) Inhibition of mouse testicular DNA synthesis by mutagens and carcinogens as a potential simple mammalian assay for mutagenesis. Mutat Res 37:67–76.

    Article  CAS  PubMed  Google Scholar 

  • Garberg P, Akerblom E-L, Bolcsfoldi G (1988) Evaluation of a genotoxicity test measuring DNA-strand breaks in mouse lymphoma cells by alkaline unwinding and hydroxyapatite elution. Mutat Res 203:155–176.

    Article  CAS  PubMed  Google Scholar 

  • Gause EM, Hartmann RJ, Leal BZ, Geller I (1985) Neurobehavioral effects of repeated sublethal soman in primates. Pharmacol Biochem Behav 23:1003–1012.

    Article  CAS  PubMed  Google Scholar 

  • Geller L, Hartmann RJ, Gause EM (1985) Effects of subchronic administration of soman on acquisition of avoidance-escape behavior by laboratory rats. Pharmacol Biochem Behav 23:225–230.

    Article  CAS  PubMed  Google Scholar 

  • Geller I, Sawa A, Stavinoha WB (1987) Effects of subchronic soman on avoidance-escape behavior and cholinesterase activity. Neurotoxicol Teratol 9:377–386.

    Article  CAS  PubMed  Google Scholar 

  • Gibson PB, Brink RA, Stahmann MA (1950) The mutagenic action of mustard gas on Zea mays. J Hered 41:232–238.

    Article  CAS  PubMed  Google Scholar 

  • Goldman M, Dacre JC (1989) Lewisite: its chemistry, toxicology, and biological effects. Rev Environ Contam Toxicol 110:75–115.

    Article  CAS  PubMed  Google Scholar 

  • Goldman M, Klein AK, Kawakami TG, Rosenblatt LS (1987) Toxicity studies on agents GB and GD. DTIC: AD A187841. Laboratory for Energy-Related Health Research. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Goldman M, Wilson BW, Kawakami TG, Rosenblatt LS, Culbertson MR, Schreider JP, Remsen JF, Shifrine M (1988) Toxicity studies on agent VX. DTIC: AD A201397. Laboratory for Energy-Related Health Research. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Goldstein BD (1989) Changes in spinal cord reflexes following subchronic exposure to soman and saran. Toxicol Lett 47:1.

    Article  CAS  PubMed  Google Scholar 

  • Goldstein BD, Fincher DR, Searle JR (1987) Electrophysiological changes in the primary sensory neuron following subchronic soman and sann: alterations in sensory receptor function. Toxicol Appl Pharmacol 91:55–64.

    Article  CAS  PubMed  Google Scholar 

  • Gordon JJ, Inns RH, Johnson MK, Leadbeater L, Maidment MP, Upshall DG, Cooper GH, Rickard RL (1983) The delayed neuropathic effects of nerve agents and some other organophosphorus compounds. Arch Toxicol 52:71–82.

    Article  CAS  PubMed  Google Scholar 

  • Grant WM (1974) Toxicology of the Eye: Drugs, Chemicals, Plants, Venoms, 2nd Ed. Thomas, Springfield, IL, pp 339–340.

    Google Scholar 

  • Grob D, Harvey JC (1958) Effects in man of the anticholinesterase compound sann (isopropyl methyl phosphonofluoridate). J Clin Invest 37(1):350–368.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hackett PL, Rommereim RL, Burton FG, Buschbom RL, Sasser LB (1987) Teratology studies on lewisite and sulfur mustard agents: effects of sulfur mustard in rats and rabbits. DTIC: AD A187495. Pacific Northwest Laboratory, Richland, WA. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Hambrook JL, Howells DJ, Utley D (1971) Degradation of phosphonates. Breakdown of soman (O-pinacolyl-methylphosphonofluoridate) in wheat plants. Pestic Sci 2:172–175.

    Article  CAS  Google Scholar 

  • Hardy HL, Boylen GW Jr (1983) Cyanogen, hydrocyanic acid and cyanides. In: Parmeggiani L (ed) Encyclopaedia of Occupational Health and Safety, 3rd Ed., vol 1. International Labour Office, Geneva, pp 574–577.

    Google Scholar 

  • Harris BL, Shanty F, Wiseman WJ (1979) Chemicals in war. In: Kirk-Othmer Encyclo-pedia of Chemical Technology, 3rd Ed., vol 5. Wiley, New York, pp 393–416.

    Google Scholar 

  • Harris H, Whittaker M (1962) The serum cholinesterase variants: study of twenty-two families selected via the “intermediate” phenotype. Ann Hum Genet 26:59–72.

    Article  CAS  PubMed  Google Scholar 

  • Harris LW, Heyl WC, Stitcher DL, Broomfield CA (1978) Effects of 1,1-oxydimethylene-bis-(4-tert-butyl pyridinium chloride) (SAD-128) and decamethonium on reactivation of soman-and sarin-inhibited cholinesterase by oximes. Biochem Pharmacol 27:757–761.

    Article  CAS  PubMed  Google Scholar 

  • Harris LW, Lennox WJ, Talbot BG (1984) Toxicity of anticholinesterase: interactions of pyridostigmine and physostigmine with soman. Drug Chem Toxicol 7:507–526.

    Article  CAS  PubMed  Google Scholar 

  • Hartung R (1994) Cyanides and nitriles. In: Clayton GD, Clayton E (eds) Patty’s Industrial Hygiene and Toxicology, vol II, part D, Toxicology. Wiley, New York, pp 3119–3172.

    Google Scholar 

  • Harvey SP, DeFrank JJ (1993) Biodegradation of chemical warfare agents: demilitarization applications. In: Kamely D, Sasmore R (eds) Army Science: the New Frontier, Military and Civilian Applications. Borg Biomedical Services, Woodlands, TX.

    Google Scholar 

  • Haskin D (1948) Some effects of nitrogen mustards on the development of the external body form in the fetal rat. Anat Rec 102:493–511.

    Article  CAS  PubMed  Google Scholar 

  • Hassett DD (1963) Study of long-term human and ecological effects of chemical weapons systems. CRDL Special Publ 2–52. U.S. Department of the Army, Chemical Research and Development Laboratories, Edgewood Arsenal, MD. (Cited in DA 1988.)

    Google Scholar 

  • Hayes WJ (1982) Pesticides Studied in Man. William & Wilkins, Baltimore.

    Google Scholar 

  • Henderson JD, Higgins RJ, Rosenblatt D, Wilson BW (1989) Toxicity studies on agent GA: delayed neurotoxicity—acute and repeated exposures to GA (tabun). DTIC: AD A219457. U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Henderson JD, Higgins RJ, Dacre JC, Wilson BW (1992) Neurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and isofenphos to the hen. Toxicology 72:117–129.

    Article  CAS  PubMed  Google Scholar 

  • Hertting GO, Kraupp E, Schnetz E, Wieketich ST (1960) Untersuchungen über die Folgen einer chronischen Verabreichung akut toxischen Dosen von Natriumcyanid an Hunden [Experiments on the chronic administration of acutely toxic doses of sodium cyanide in dogs]. Acta Pharmacol Toxicol 17:27–43.

    Article  CAS  Google Scholar 

  • Heston WE (1942) Inheritance of susceptibility to spontaneous pulmonary tumors in mice. J Natl Cancer Inst 3:79–82.

    Google Scholar 

  • Heston WE (1950) Carcinogenic action of mustards. J Natl Cancer Inst 11:415–423.

    CAS  PubMed  Google Scholar 

  • Heston WE (1953) Occurrence of tumors in mice injected subcutaneously with sulfur mustard and nitrogen mustard. J Natl Cancer Inst 14:131–140.

    CAS  PubMed  Google Scholar 

  • Heston WE, Levillain WD (1953) Pulmonary tumors in strain A mice exposed to mustard gas. Proc Soc Exp Biol 82:457–460.

    Article  CAS  PubMed  Google Scholar 

  • Ho IK, Hoskins B (1983) Basal ganglia dopamine-gamma aminobutyric acid-acetylcholine interaction in organophosphate-induced neurotoxicity. AD B09I748. Second annual report to the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Holmstedt B (1951) Synthesis and pharmacology of dimethylamidoethoxyphosphoryl cyanide (tabun) together with a description of some allied anticholinesterase compounds containing the NP bond. Acta Physiol Scand 25(suppl 90):1–120.

    Google Scholar 

  • Holmstedt B (1959) Pharmacology of organophosphorus cholinesterase inhibitors. Pharmacol Rev 11:567–688.

    CAS  PubMed  Google Scholar 

  • Hoskins B, Ho IK (1992) Tolerance to organophosphate cholinesterase inhibitors. In: Chamber JE, Levi PE (eds) Organophosphates: Chemistry Fate and Effects. Academic Press, New York, pp 285–297.

    Chapter  Google Scholar 

  • Hott PD, Alexander TB (1959) Field bioassay of VX by means of goldfish. Tech Rep CWRL 2324 (DTIC:AD 314164). U.S. Department of the Army, Chemical Warfare Laboratories, Army Chemical Center, MD.

    Google Scholar 

  • Houle MJ, Long DE, Lee TD, Meikle JE, Griffiths TA (1972) The decay of GB in environmental samples (SATEST). DTC-PR-73–852. Deseret Test Center, Fort Douglas, UT. (Cited in Sigal and Suter 1989.)

    Google Scholar 

  • Howard JW, Hanzal RF (1955) Chronic toxicity to rats of food treated with hydrogen cyanide. J Agric Food Chem 3:325–329.

    Article  CAS  Google Scholar 

  • Howells G (1983) Acid waters: the effect of low pH and acid associated factors on fisheries. Adv Appl Biol 9:143–255.

    Google Scholar 

  • HSDB (1993) Mechlorethamine. Hazardous Substance Data Base, online file, retrieved March 1993. National Library of Medicine, Washington, DC.

    Google Scholar 

  • HSDB (1995) Cyanogen chloride. Hazardous Substances Data Bank, online file, retrieved 1995. National Library of Medicine, Washington, DC.

    Google Scholar 

  • HSDB (1997) bis(2-Chloroethyl)sulfide. Hazardous Substance Data Base, online file, retrieved March 1997. National Library of Medicine, Washington, DC.

    Google Scholar 

  • Husain K, Vijayaraghavan R, Pant SC, Raza SK, Pandey KS (1993) Delayed neurotoxic effect of sarin in mice after repeated inhalation exposure. J Appl Toxicol 13:1435.

    Article  Google Scholar 

  • Husain K, Pant SC, Raza SK, Singh R, Das Gupta S (1995) A comparative study of delayed neurotoxicity in hens following repeated administration of organophosphorus compounds. Indian J Physiol Pharmacol 39:47–50.

    CAS  PubMed  Google Scholar 

  • Hymowitz N, Brezenoff HE, McGee J, Campbell K, Knight V (1985) Effect of repeated intraperitoneal injections of soman on schedule-controlled behavior in the rat. Psycho-pharmacology 86:404–408.

    Article  CAS  Google Scholar 

  • IARC (1975) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man: Some Aziridines, N, S, & 0-Mustards and Selenium, vol 9. International Agency for Research on Cancer, Lyon, France, pp 181–207.

    Google Scholar 

  • IARC (1987a) IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans. Overall Evaluation of Carcinogenicity: An Updating of IARC Monographs, vols 1–42, suppl 7. International Agency for Research on Cancer, Lyon, France, p 67.

    Google Scholar 

  • IARC (1987b) IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans. Overall Evaluation of Carcinogenicity: An Updating of IARC Monographs, vols 1–42, suppl 7. International Agency for Research on Cancer, Lyon, France, pp 1–42; 1–42.

    Google Scholar 

  • IARC (1987c) IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans. Overall Evaluation of Carcinogenicity: An Updating of IARC Monographs, vols 1–42, suppl 7. International Agency for Research on Cancer, Lyon, France.

    Google Scholar 

  • Idriss MK, Aguayo LG, Rickett DL, Albuquerque EX (1986) Organophosphate and carbamate compounds have pre-and postjunctional effects at the insect glutamatergic synapse. J Pharmacol Exp Ther 239:279–285.

    CAS  PubMed  Google Scholar 

  • Inada S, Hiragun K, Seo K, Yamura T (1978) Multiple Bowen’s disease observed in former workers of a poison gas factory in Japan, with special reference to mustard gas exposure. J Dermatol (Tokyo) 5:49–60.

    Article  CAS  Google Scholar 

  • Institute of Medicine (1993) Veterans at Risk: The Health Effects of Mustard Gas and Lewisite, Pechura CM, Rall DP (eds) Committee to Survey the Health Effects of Mustard Gas and Lewisite. Division of Health Promotion and Disease Prevention, National Academy Press, Washington, DC.

    Google Scholar 

  • ITII (1975) Toxic and Hazardous Industrial Chemicals Safety Manual. International Technical Information Institute, Tokyo, Japan, p 351.

    Google Scholar 

  • Ivanov P, Georgiev B, Kirov K, Venkov L (1993) Correlation between concentration of cholinesterase and the resistance of animals to organophosphorus compounds. Drug Chem Toxicol 16:81–99.

    Article  CAS  PubMed  Google Scholar 

  • Jacobs MB (1942) The physical characteristics and physiological response of the war gases. In: War Gases, Their Identification and Decontamination. Interscience, New York, pp 14–44.

    Google Scholar 

  • Jimmerson VR, Shih T-M, Mailman RB (1989) Variability in soman toxicity in the rat: correlation with biochemical and behavioral measures. Toxicology 57:241–254.

    Article  CAS  PubMed  Google Scholar 

  • Johnsen BA, Blanch JH (1984) Analysis of snow samples contaminated with chemical warfare agents. Arch Belg Med Soc Hyg Med Tray Med Leg, suppl, pp 22–30 (Proceedings 1st World Congress on New Compounds in Biological Chemical and Warfare Toxicological Evaluation) State University of Ghent, B-9000 Ghent, Belgium, A. Heyndrickx, ed.

    Google Scholar 

  • Johnson MK, Willems JL, De Bisschop HC, Read DJ, Benschop HP (1988) High doses of soman protect against organophosphorus-induced polyneuropathy but tabun does not. Toxicol Appl Pharmacol 92:34–41.

    Article  CAS  PubMed  Google Scholar 

  • Jokanovie M (1989) Role of carboxylesterase in soman, sarin, and tabun poisoning in rats. Pharmacol Toxicol 65:181–184.

    Article  Google Scholar 

  • Jones DE, Koplovitz I, Harrington DG, Hilmas DE, Canfield CJ (1984) Models for assessing efficacy of therapy compounds against organophosphates (OP). Proc Fourth Ann Chem Def Biosci Rev, pp 1–38. U.S. Department of the Army, Medical Research and Development Command. (Cited in Somani et al. 1992.)

    Google Scholar 

  • Jostes RF Jr, Sasser LB, Rausch RJ (1989a) Toxicology studies on lewisite and sulfur mustard agents: genetic toxicity of sulfur mustard (HD) in the Chinese hamster ovary cells. PNL-6916. Pacific Northwest Laboratories. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Jostes RF Jr, Sasser LB, Rausch RJ (1989b) Toxicology studies on lewisite and sulfur mustard agents: genetic toxicity of lewisite (L) in Chinese hamster ovary cells. PNL6922. Pacific Northwest Laboratory, Richland, WA.

    Google Scholar 

  • Kaaijk J, Frijlink C (1977) Degradation of S-2-diisopropylaminoethyl 0-ethyl methylphonothioate in soil: sulfur-containing products. Pestic Sci 8:510–514.

    Article  CAS  Google Scholar 

  • Kamalu BP (1993) Pathological changes in growing dogs fed on a balanced cassava (Manihot esculenta Crantz) diet. Br J Nutr 69:921–934.

    Article  CAS  PubMed  Google Scholar 

  • Karube I, Matsunaga T, Nakahara T, Suzuki S (1981) Preliminary screening of mutagens with a microbial sensor. Anal Chem 53:1024–1026.

    Article  CAS  Google Scholar 

  • Kimura KK, McNamara BP, Sim VM (1960) Intravenous administration of VX in man. Tech Rep CRDLR 3017. U.S. Department of the Army, Chemical Corps Research and Development Command, Chemical Research and Development Laboratories, Army Chemical Center, MD.

    Google Scholar 

  • Kingery AF, Allen HE (1995) The environmental fate of organophosphorus nerve agents: a review. Toxicol Environ Chem 47:155–184.

    Article  CAS  Google Scholar 

  • Kircher M, Brendel M (1983) DNA alkylation by mustard gas in yeast Saccharomyces cerevisiae strains of different repair capacity. Chem Biol Interact 44:27–39.

    Article  CAS  PubMed  Google Scholar 

  • Kistner SL, Adams JD, Cerar RJ, Hauschild VD, Hess TL, Kavanagh WG, Ward JR, Watson AP (1992) Unitary agents: a road map to control limits and analytical methods. In: Proceedings, 16th Annual Army Environmental R&D Symposium, Williamsburg, VA, June 23–25, 1992.

    Google Scholar 

  • Klehr N (1984) Cutaneous late manifestation in former mustard gas workers. Z Hautkr 59:1161–1170. (In German with English abstract.)

    CAS  PubMed  Google Scholar 

  • Klein AK, Nasr ML, Goldman M (1987) The effects of in vitro exposure to the neurotoxins sann (GB) and soman (GD) on unscheduled DNA synthesis by rat hepatocytes. Toxicol Lett 38:239–249.

    Article  CAS  PubMed  Google Scholar 

  • Kononen DW (1988) Acute toxicity of cyanogen chloride to Daphnia magna. Bull Environ Contam Toxicol 41:371–377.

    Article  CAS  PubMed  Google Scholar 

  • Krasner SW, McGuire MJ, Jacangelo JG, Patania NL, Reagan KM, Aieta EM (1989a) The occurrence of disinfection by-products in drinking water in a nationwide study. Proc Annu Conf Am Water Works Assoc, Iss (pt 2):1171–1202.

    Google Scholar 

  • Krasner SW, McGuire MJ, Jacangelo JG, Patania NL, Reagan KM, Aieta EM (1989b) The occurrence of disinfection by-products in U.S. drinking water. Am Water Works Assoc J 81:41–53.

    Article  CAS  Google Scholar 

  • Krause H, Grussendorf EI (1978) Syntopy of Bowen’s disease and lewisite scar. Hautarzt 29:490–493.

    CAS  PubMed  Google Scholar 

  • Kushi A, Matsumoto T, Yoshida D (1983) Mutagen from the gaseous phase of protein pyrolyzate. Agric Biol Chem 47:1979–1982.

    CAS  Google Scholar 

  • LaBorde JB, Bates HK (1986) Developmental toxicity study of agent GB-DCSM types I and II in CD rats and NZW rabbits. National Center for Toxicological Research, Jefferson, AR. Prepared for U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • LaBorde JB, Bates HK, Dacre JC, Young JF (1996) Developmental toxicity of sarin in rats and rabbits. J Toxicol Environ Health 47:249–265.

    Article  CAS  PubMed  Google Scholar 

  • Landauer MR, Romano JA (1984) Acute behavioral toxicity of the organophosphate sarin in rats. Neurobehav Toxicol Teratol 6:239–243.

    CAS  PubMed  Google Scholar 

  • Landing BH, Goldin A, Noe HA (1949a) Testicular lesions in mice following parenteral administration of nitrogen mustard. Cancer (Phila) 2:1075–1082.

    Article  CAS  Google Scholar 

  • Landing BH, Goldin A, Noe HA (1949b) Systemic pathological effects of nitrogen mustards, and a comparison of toxicity, chemical structure, and cytotoxic effect, with reference to the chemotherapy of tumors. Cancer (Phila) 2:1055–1066.

    Article  CAS  Google Scholar 

  • Lawley PD, Brookes P (1965) Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action. Nature (Lond) 206:480–483.

    Article  CAS  Google Scholar 

  • Lee TS, Weigand WA, Bentley WE (1997) Observations of metabolite formation and variable yield in thiodiglycol biodegradation process: impact on reactor design. Appl Biochem Biotechnol 63–65:63–65.

    Google Scholar 

  • Lehmann H, Liddell J (1969) Human cholinesterase (pseudocholinesterase) genetic variants and their recognition. Br J Anaesthesiol 41:235–244.

    Article  CAS  Google Scholar 

  • Leitch JL, Ginsberg TH, Price ME (1941) Purification of water contaminated with lewisite: a toxicological study of water containing 10 ppm and 16 ppm of lewisite. Memo rep 18. U.S. Department of the Army, Medical Research Division, Edgewood Arsenal, MD. (Cited in Daniels 1990.)

    Google Scholar 

  • Lennox WJ, Harris LW, Talbot BG, Anderson DR (1985) Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality. Life Sci 37: 793–798. (Cited in Somani et al. 1992.)

    Article  CAS  PubMed  Google Scholar 

  • Lewis lu, Sweet DV (eds) (1984) Registry of Toxic Effects of Chemical Substances, 1983 Supplement to the 1981–82 edition. U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, OH, pp 1981–82.

    Google Scholar 

  • Lide DR (ed) (1991) CRC Handbook of Chemistry and Physics, 72nd Ed., 1991–1992. CRC Press, Boca Raton, FL.

    Google Scholar 

  • Lyman WJ, Reehl WF, Rosenblatt DH (1982) Handbook of Chemical Property Estimation Methods. McGraw-Hill, New York.

    Google Scholar 

  • Mabey W, Mill T (1978) Critical review of hydrolysis of organic compounds in water under environmental conditions. J Phys Chem Ref Data 7:383–415.

    Article  CAS  Google Scholar 

  • MacNaughton MG, Brewer JH (1994) Environmental chemistry and fate of chemical warfare agents. SWRI Project 01–5864. Southwest Research Institute, San Antonio, TX.

    Google Scholar 

  • Maderna J (1986) Mustard gas: the science of H. Nucl Biol Chem Def Int 1:66–71.

    Google Scholar 

  • Manning KP, Skegg DCG, Stell PM, Doll R (1981) Cancer of the larynx and other occupational hazards of mustard gas workers. Clin Otolaryngol 6:165–170.

    Article  CAS  PubMed  Google Scholar 

  • Marquis JK (ed) (1988) Cholinesterase inhibition as an indication of adverse toxicologic effects. Review draft (June, 1988). Prepared for the Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • Maxwell DM, Lenz DE, Groff WA, Kaminskis A, Froehlich HL (1987) The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats. Toxicol Appl Pharmacol 88:66–76.

    Article  CAS  PubMed  Google Scholar 

  • Maxwell DM, Brecht KM, Lenz DE, O’Neil BL (1988) Effect of carboxylesterase inhibition on carbamate protection against soman toxicity. J Pharmacol Exp Ther 246:986–991.

    CAS  PubMed  Google Scholar 

  • McDonough JH, Smith RF, Smith CD (1986) Behavioral correlates of soman-induced neuropathology: deficits in DRL acquisition. Neurobehav Toxicol Teratol 8:179–187.

    CAS  PubMed  Google Scholar 

  • McLeod CG Jr (1985) Pathology of nerve agents: perspectives on medical management. Fundam Appl Toxicol 5:S10–S16.

    Article  CAS  PubMed  Google Scholar 

  • McNamara BP, Leitnaker F (1971) Toxicological basis for controlling emission of GB into the environment. EASP 100–98 (DTIC: AD 914271L). U.S. Department of the Army, Medical Research Laboratory, Edgewood Arsenal, Aberdeen Proving Ground, MD.

    Google Scholar 

  • McNamara BP, Leitnaker F, Vocci FJ (1973) Proposed limits for human exposure to VX vapor in nonmilitary operations. EASP 1100–1 (R-1) (DTIC: AD 770434/9). U.S. Department of the Army, Medical Research Laboratory, Edgewood Arsenal, Aberdeen Proving Ground, MD.

    Google Scholar 

  • McNamara BP, Owens EJ, Christensen MK, Vocci FJ, Ford DF, Rozimzrek H (1975) Toxicological basis for controlling levels of mustard in the environment. EASP EBSP 74030. U.S. Department of the Army, Biomedical Laboratory, Edgewood Arsenal, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Meinck F, Stoof H, Kohlschutter H (1956) Industrial Waste Waters (Industrie-Abwas-ser), 2nd Ed. Gustav Fischer Verlag, Stuttgart. (Cited in Kononen 1988.)

    Google Scholar 

  • Ministry of Health, Mozambique (1984a) Mantakassa: an epidemic of spastic parapesis associated with chronic cyanide intoxication in a cassava staple area of Mozambique.1. Epidemiology and clinical and laboratory findings in patients. Bull WHO 62:477–484.

    Google Scholar 

  • Ministry of Health, Mozambique (1984b) Mantakassa: an epidemic of spastic parapesis associated with chronic cyanide intoxication in a cassava staple area of Mozambique. 2. Nutritional factors and hydrocyanic acid content in cassava. Bull WHO 62:485–492.

    Google Scholar 

  • Mitchell CA, Carroll PA (1989) Acute toxicity of inhaled gases and particulates. Med J Aust 150:717–720.

    Article  CAS  PubMed  Google Scholar 

  • Moeller HC, Rider JA (1962) Plasma and red blood cell cholinesterase activity as indications of the threshold of incipient toxicity of ethyl-p-nitrophenyl thiobenzenephosphorate (EPN) and malathion in human beings. Toxicol Appl Pharmacol 4:123–130.

    Article  CAS  PubMed  Google Scholar 

  • Morgan DP (1989) Recognition and Management of Pesticide Poisonings, 4th Ed. EPA-540/9–88–001. U.S. Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • Morgenstern P, Koss FR, Alexander WW (1947) Residual mustard gas bronchitis; effects of prolonged exposure to low concentrations. Ann Intern Med 26:27–40.

    Article  CAS  PubMed  Google Scholar 

  • Morin ML, McKinley ER (1976) Evaluation of the effect of low-level GB exposure on testicular atrophy in the Fischer 344 rat. EA-TR-75031. U.S. Department of the Army, Edgewood Arsenal, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Morrill LG, Reed LW, Chinn KSK (1985) Toxic chemicals in the soil environment, vol 2, Interaction of some toxic chemicals/chemical warfare agents and soils. TECOM Project 2-CO-210–049 (DTIC: AD-A158 215). Oklahoma State University, Stillwater.

    Google Scholar 

  • Munro NB, Ambrose KR, Watson AP (1994) Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection. Environ Health Perspect 102:18–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murphy ML, Del Moro A, Lacon C (1958) The comparative effects of five polyfunctional alkylating agents on the rat fetus, with additional notes on the chick embryo. Ann NY Acad Sci 68:762–782.

    Article  CAS  PubMed  Google Scholar 

  • Nakamura T (1956) Studies on the warfare gas-injury in Japan. Report I, On the general condition of the poison gas island. Hiroshima Med J 4:1141–1149. (In Japanese, cited in Inada et al. 1978.)

    Google Scholar 

  • NDRC (1946a) Chemical warfare agents and related chemical problems, vol 1. National Defense Research Committee, Office of Scientific Research and Development, Washington, DC.

    Google Scholar 

  • NDRC (1946b) Hydrogen cyanide and cyanogen chloride. In: Preparation and evaluation of potential chemical warfare agents. Summary Technical Report of Division 9, NDRC, vol 1, part 1, chapter 2. National Defense Research Committee, Office of Scientific Research and Development, Washington, DC, pp 7–16.

    Google Scholar 

  • Nieminen SA, Lecklin A, Heikkinen O, Ylitalo P (1990) Acute behavioral effects of the organophosphates sann and soman in rats. Pharmacol Toxicol 67:36–40.

    Article  CAS  PubMed  Google Scholar 

  • Nishimoto Y, Yamakido M, Shigenobu T, Onari K, Yukutake M (1983) Long term observations of poison gas workers with special reference to respiratory cancers. J UOEH (Univ Occup Environ Health) 5(suppl):89–94.

    Google Scholar 

  • Nishimoto Y, Yamakido M, Ishioka S, Shigenobu T, Yukutake M (1988) Epidemiological studies of lung cancer in Japanese mustard gas workers. In: Miller RW, et al (eds) Unusual occurrences as clues to cancer etiology. Japan Science Society Press, Tokyo, pp 95–101.

    Google Scholar 

  • NMFA (1982, 1983) Verification of a chemical weapons convention: sampling and analysis of chemical warfare agents under winter conditions, parts 1 and 2. Royal Norwegian Ministry of Foreign Affairs, Oslo. (Cited in Trapp 1985; Kingery and Allen 1994.)

    Google Scholar 

  • Norman J (1975) Lung cancer mortality in World War I veterans with mustard gas injury: 1919–1945. J Natl Cancer Inst 54:1919–1945.

    Article  PubMed  Google Scholar 

  • NRC (1977) Organic solutes. In: Drinking Water and Health. National Research Council, National Academy of Sciences, Washington, DC, pp 717–718.

    Google Scholar 

  • NTP (1993) Sodium cyanide (CAS No. 143–33–9) administered in drinking water to F344/N rats and B6C3F, mice. NTP Toxicity report series no. 37 (NIH Publication 143–33). U.S. Department of Health and Human Services, National Toxicology Program, Washington, DC.

    Google Scholar 

  • NTP (1994) Annual report on carcinogens. National Toxicology Program, Research Triangle Park, NC.

    Google Scholar 

  • O’Brien RD (1960) Toxic Phosphorus Esters: Chemistry Metabolism and Biological Effects. Academic Press, New York, pp 175–239.

    Book  Google Scholar 

  • Ohya T, Kanno S (1985) Formation of cyanide ion or cyanogen chloride through the cleavage of aromatic rings by nitrous acid or chlorine. VIII: On the reaction of humic acid with hypochlorous acid in the presence of ammonium ion. Chemosphere 14: 1717–1722. (Cited in Clark 1989.)

    Article  CAS  Google Scholar 

  • Olajos EJ, Bergmann J, Weimer JT, Wall H (1986) Neurotoxicity assessment of 0-ethylO’-(2-diisopropylaminoethyl)methylphosphonite (QL) in hens. J Appl Toxicol 6:135143.

    Google Scholar 

  • Olson CT, Menton RG, Kiser RC, Hobson DW, Dill GS, Joiner RL, Stewart JR (1989) Evaluating the efficacy of antidote drug combinations against soman toxicity in the rabbit. USAMRIDC Med Def Biosci Rev, pp 667–670. (Cited in Somani et al. 1992.)

    Google Scholar 

  • Opresko D, Daugherty M, Etnier E, Faust, R, Talmage S, Young R, Watson A, Ross R (1994) Estimated control limits, technologies and regulatory requirements for remedi-ating sites potentially contaminated with nonstockpile chemical materiel. Draft report, prepared by Oak Ridge National Laboratory for the U.S. Department of the Army, Army Environmental Center, Aberdeen Proving Ground, MD

    Google Scholar 

  • Osweiler GD, Carson TL, Buck WB, Van Gelder GA (1985) Clinical and Diagnostic Veterinary Toxicology, 3rd Ed. Kendall/Hunt, Dubuque, IA.

    Google Scholar 

  • Papirmeister B, Feister AF, Robinson SI, Ford RD (1991) Medical Defense Against Mustard Gas: Toxic Mechanisms and Pharmacological Implications. CRC Press, Boca Raton, FL.

    Google Scholar 

  • Perera J, Thomas A (1986) Mustard gas at the bottom of the garden. New Sci 109:18–19.

    Google Scholar 

  • Petrali JP (1989) Anticholinesterase toxicity of endothelial cells. USAMRDC Med Def Biocsi Rev:95–98. (Cited in Somani et al. 1992.)

    Google Scholar 

  • Petras JM (1984) Brain pathology induced by organophosphate poisoning with nerve agent soman. DTIC: AD B089975. Proc 4th Annu Chem Biosci Rev:407. (Cited in Baze 1993.)

    Google Scholar 

  • Philbrick DJ, Hopkins JB, Hill DC, Alexander JC, Thomson RG (1979) Effects of prolonged cyanide and thiocyanate feeding in rats. J Toxicol Environ Health 5:579–592.

    Article  CAS  PubMed  Google Scholar 

  • PMCD Newsletter (1997) Pursuit of alternative technologies authorized for Aberdeen and Newport stockpiles. Program Manager for Chemical Demilitarization Newsletter, Aberdeen Proving Ground, MD, March 1977, p. 2.

    Google Scholar 

  • POISINDEX (1993) Mechlorethamine. Micromedex, Inc., retrieved as part of Hazardous Substances Data Base (HSDB), March 1993.

    Google Scholar 

  • Price CC, von Limbach B (1945) Further data on the toxicity of various CW agents to fish. OSRD 5528. National Defense Research Committee, Office of Scientific Research and Development. (Cited in Rosenblatt et al. 1975.)

    Google Scholar 

  • Puzderliski A (1980) The persistence of satin and yperite drops in soil. Naucno-Teh Pregl 30:47–54 (translated from Serbo-Croatian).

    CAS  Google Scholar 

  • Raveh L, Grauer E, Grunwald J, Cohen E, Ashani Y (1997) The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase. Toxicol Appl Pharmacol 145:43–53.

    Article  CAS  PubMed  Google Scholar 

  • Reed CI (1920) Chronic poisoning from cyanogen chloride. Q J Ind Hyg 2:140–143.

    CAS  Google Scholar 

  • Renshaw B (1946) Mechanisms in production of cutaneous injuries by sulfur and nitrogen mustards. In: Chemical Warfare Agents and Related Chemical Problems, vol 1. National Defense Research Committee, Office of Scientific Research and Development, Washington, DC, pp 479–518.

    Google Scholar 

  • Reutter SA, Wade JV (1994) Review of existing toxicity data and human estimates for selected chemical agents and recommended human toxicity estimates appropriate for defending the soldier. ERDEC-SP-018. U.S. Department of the Army, Edgewood Research Development and Engineering Center, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Rewick RT, Shumacher ML, Haynes DL (1986) The UV absorption spectra of chemical agents and simulants. Appl Spectrosc 40:152–156.

    Article  CAS  Google Scholar 

  • Rice GB, Lambert TW, Haas B, Wallace V (1971) Effect of chronic ingestion of VX on ovine blood cholinesterase. DTC 71–512. Deseret Test Center, Dugway Proving Ground, Dugway, UT.

    Google Scholar 

  • Rider JA, Ellinwood LE, Coon JM (1952) Production of tolerance in the rat to octamethylpyrophosphoramide (OMPA). Proc Soc Exp Biol Med 81:455–459.

    Article  CAS  PubMed  Google Scholar 

  • Robinson JP (1967) Chemical warfare. Science J 4:33–40.

    Google Scholar 

  • Rosenblatt DH, Miller TA, Dacre JC, Muul I, Cogley DR (1975) Problem definition studies on potential environmental pollutants. II. Physical, chemical, toxicological, and biological properties of 16 substances. Tech Rep 7509 (DTIC: AD AO30428). U.S. Department of the Army, Medical Bioengineering Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Rosenblatt DH, Small MJ, Kimmell TA, Anderson AW (1995) Agent decontamination chemistry: technical report, phase 1. Prepared for U.S. Department of the Army, Environmental Quality Office, Test and Evaluation Command (TECOM) Aberdeen Proving Ground, MD.

    Google Scholar 

  • Ross RH, Daugherty ML, Holleman JW, Pal BC, Smith LW, Dacre JC (1983) Problem definition study on agent VX: demilitarization, health effects, and toxicology. ORNL/ EIS-200. Oak Ridge National Laboratory, Oak Ridge, TN. Prepared for U.S. Department of the Army, Toxic and Hazardous Materials Agency, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Rozmiarek H, Capizzi RL, Papirmeister B, Fuhrman WH, Smith WJ (1973) Mutagenic activity in somatic and germ cells following chronic inhalation of sulfur mustard. Mutat Res 21:13–14.

    Article  Google Scholar 

  • RTECS (1995a) GA. Registry of Toxic Effects of Chemical Substances, MEDLARS Online Information Retrieval System, National Library of Medicine, Washington, DC.

    Google Scholar 

  • RTECS (1995b) Tributylamine. Registry of Toxic Effects of Chemical Substances, MEDLARS Online Information Retrieval System, National Library of Medicine, Washington, DC.

    Google Scholar 

  • RTECS (1995c) GB. Registry of Toxic Effects of Chemical Substances, MEDLARS Online Information Retrieval System, National Library of Medicine, Washington, DC.

    Google Scholar 

  • RTECS (1995d) Cyanogen chloride. Registry of Toxic Effects of Chemical Substances, MEDLARS Online Information Retrieval System, National Library of Medicine, Washington, DC.

    Google Scholar 

  • Russell RW, Booth RA, Lauretz SD, Smith CA, Jenden DJ (1986) Behavioral, neurochemical and physiological effects of repeated exposures to subsymptomatic levels of anticholinesterase, soman. Neurobehav Toxicol Teratol 8:675–685.

    CAS  PubMed  Google Scholar 

  • Sabourin TD, Moore EL Jr, Durell GS (1987) Acute aquatic toxicity of cyanogen chloride to Daphnia magna and fathead minnows (Pimephales promelas). BA-870911 (USEPA: OTS 0538530). Battelle Memorial Institute, Columbus, OH. Prepared for Monsanto Company, St. Louis, MO.

    Google Scholar 

  • Sage GW, Howard PH (1989) Environmental fate assessments of chemical agents HD and VX. CRDEC-CR-034. U.S. Department of the Army, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Sanches ML, Russell CR, Randolf CL (1993) Chemical weapons convention (CWC) signature analysis. DNA-TR-92–73 (DTIC: AD B 171788). Defense Technical Information Center, Alexandria, VA.

    Google Scholar 

  • Sanyal MK, Kitchin KT, Dixon RL (1981) Rat conceptus development in vitro: comparative effects of alkylating agents. Toxicol Appl Pharmacol 57:14–19.

    Article  CAS  PubMed  Google Scholar 

  • Sass S, Fisher TL, Stutz MH, Piffath RJ (1970) Analysis of environmental samples from area of sheep deaths near Dugway Proving Ground (U). EASP 100–69. U.S. Department of the Army, Edgewood Arsenal, MD.

    Google Scholar 

  • Sasser LB, Miller RA, Kalkwarf DR, Buschbom RL, Cushing JA (1989a) Toxicology studies on lewisite and sulfur mustard agents: subchronic toxicity of sulfur mustard (HD) in rats. PNL-6870 (DTIC: AD A2144555). Pacific Northwest Laboratories. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Sasser LB, Miller RA, Kalkwarf DR, Buschbom RL, Cushing JA (1989b) Toxicology studies on lewisite and sulfur mustard agents: two-generation reproduction study of sulfur mustard (HD) in rats. PNL 6944 (DTIC: AD A216423). Pacific Northwest Laboratories. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Sasser LB, Cushing JA, Kalkwarf DR, Mellick PW, Buschbom RL (1989c) Toxicology studies on lewisite and sulfur mustard agents: subchronic toxicity study of lewisite in rats. PNL-6860. Pacific Northwest Laboratory, Richland, WA.

    Book  Google Scholar 

  • Sasser LB, Cushing JA, Kalkwarf DR, Mellick PW, Buschbom RL (1989d) Toxicology studies of lewisite and sulfur mustard agents: two-generation reproduction study of lewisite in rats. PNL-6978. Pacific Northwest Laboratory, Richland, WA.

    Book  Google Scholar 

  • Sasser LB, Miller RA, Cushing JA, Dacre JC (1990) Dominant lethal effect of sulfur mustard in rats. Toxicologist 10:225 (abstr).

    Google Scholar 

  • Sasser LB, Miller RA, Kalkwarf DR, Cushing JA, Dacre JC (1996a) Subchronic toxicity evaluation of sulfur mustard in rats. J Appl Toxicol 16:5–13.

    Article  CAS  PubMed  Google Scholar 

  • Sasser LB, Cushing JA, Mellick PW, Kalkwarf DR, Dacre JC (1996b) Subchronic toxicity of lewisite in rats. J Toxicol Environ Health 47:321–334.

    Article  CAS  PubMed  Google Scholar 

  • Sax NI (1984) Dangerous Properties of Industrial Materials, 6th Ed. Van Nostrand Reinhold, New York, pp 825–826.

    Google Scholar 

  • Scott D, Fox M, Fox BW (1974) The relationship between chromosomal aberrations, survival and DNA repair in tumor cell lines of differential sensitivity to x-rays and sulphur mustard. Mutat Res 22:207–221.

    Article  CAS  PubMed  Google Scholar 

  • Shakil FA, Kuramoto A, Yamakido M, Nishimoto Y, Kamada N (1993) Cytogenetic abnormalities of hematopoietic tissue in retired workers of the Ohkunojima poison gas factory. Hiroshima J Med Sci 42:159–165.

    CAS  PubMed  Google Scholar 

  • Shimkin MB, Weisburger JH, Weisburger EK (1966) Bioassay of 29 alkylating chemicals by the pulmonary-tumor response in strain A mice. J Natl Cancer Inst 36:915–935.

    CAS  Google Scholar 

  • Sidell FR (1992) Clinical considerations in nerve agent intoxication. In: Somani S (ed) Chemical Warfare Agents. Academic Press, New York, pp 155–194.

    Google Scholar 

  • Sidell FR, Groff WA (1974) The reactivatibility of cholinesterase inhibited by VX and sarin in man. Toxicol Appl Pharmacol 27:241–252.

    Article  CAS  PubMed  Google Scholar 

  • Side11 FR, Hurst CG (1992) Clinical considerations in mustard poisoning. In: Somani AM (ed) Chemical Warfare Agents. Academic Press, New York, pp 51–67.

    Google Scholar 

  • Sidell FR, Kaminskis A (1975) Temporal intrapersonal physiological variability of cholinesterase activity in human plasma and erythrocytes. Clin Chem 21:1961–1963.

    Article  CAS  PubMed  Google Scholar 

  • Sigal LL, Suter GW (1989) Potential effects of chemical agents on terrestrial resources. Environ Prof 11:376–384.

    Google Scholar 

  • Sim VM (1962) Variability of different intact human skin sites to the penetration of VX. Tech Rep CRDLR 3122. U.S. Department of the Army, Chemical Corps Research and Development Command, Chemical Research and Development Laboratories, Army Medical Center, MD.

    Google Scholar 

  • Sim VM, Stubbs JL (1960) Percutaneous studies in man. Tech rep CRDLR 3015 (DTIC: AD 318533). U.S. Department of the Army, Chemical Research and Development Laboratories, Army Chemical Center, MD.

    Google Scholar 

  • Sim VM, McClure C Jr, Vocci FJ, Feinsilver L, Groff WA (1964) Tolerance of man to VX-contaminated water. Tech Rep CRDLR 3231. U.S. Department of the Army, Chemical Research and Development Laboratories, Edgewood Arsenal, MD.

    Google Scholar 

  • Singer AW, Jaax NK, Graham JS, McLeod CG Jr (1987) Cardiomyopathy in soman and satin intoxicated rats. Toxicol Lett 36:243–249.

    Article  CAS  PubMed  Google Scholar 

  • Singh JD (1981) The teratogenic effects of dietary cassava on the pregnant albino rat: a preliminary report. Teratology 24:289–291.

    Article  CAS  PubMed  Google Scholar 

  • Sittig M (1985) Cyanogen chloride. In: Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2nd Ed. Noyes Publications, Park Ridge, NJ, p 276.

    Google Scholar 

  • Small MJ (1984) Compounds formed from the chemical decontamination of HD, GB, and VX and their environmental fate. Tech Rep 8304 (DTIC: AD A149515). U.S. Department of the Army, Medical Bioengineering Research and Development Laboratory, Fort Detrick, MD.

    Google Scholar 

  • Snider TH, Wientjes MG, Joiner RL, Fisher GL (1990) Arsenic distribution in rabbits after lewisite administration and treatment with British anti-lewisite (BAL). Fund Appl Toxicol 14:262–272.

    Article  CAS  Google Scholar 

  • Sokal JE, Lessmann EM (1960) Effects of cancer therapeutic agents on the human foetus. JAMA 172:1765–1771.

    Article  CAS  Google Scholar 

  • Solana R (1992) Toxicology of lewisite. Presentation before the Committee to Survey the Health Effects of Mustard Gas and Lewisite, Institute of Medicine, National Research Council, Washington, DC, June 11, 1992.

    Google Scholar 

  • Soliman TH (1957) Lewisite. In: Sollman TH (ed) Manual of Pharmacology and Its Applications to Therapeutics and Toxicology, 8th Ed. Saunders, Philadelphia, pp 192–193. (Cited in Watson and Griffin 1992.)

    Google Scholar 

  • Somani SM (1992) Toxicokinetics and toxicodynamics of mustard. In: Somani SM (ed) Chemical Warfare Agents. Academic Press, New York, pp 13–50.

    Google Scholar 

  • Somani SM, Giacobini E, Boyer A, Hallak M, Khalique A, Unni L, Hannant M, Hurley E (1986) Mechanisms of action and pharmacokinetics of physostigmine in relation to acute intoxication by organofluorophosphates. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD. (Cited in Somani et al. 1992.)

    Google Scholar 

  • Somani SM, Solana RP, Dube SN (1992) Toxicodynamics of nerve agents. In: Somani SM (ed) Chemical Warfare Agents. Academic Press, New York, pp 67–123.

    Google Scholar 

  • Sparenborg S, Jaax NK, Braitman DJ (1989) Novel anticonvulsants protect against seizures and brain damage induced by the cholinesterase inhibitor soman. USAMRIDC Med Def Biosci Rev:119–122. (Cited in Somani et al. 1992.)

    Google Scholar 

  • Stern SH, Lyngaas S, Fonnum F (1980) Toxicity of soman after repetitive injection of sublethal doses in the rat. Acta Pharmacol Toxicol 46:1–7.

    Google Scholar 

  • Sterri SH, Lyngaas S, Fonnum F (1981) Toxicity of soman after repetitive injection of sublethal doses in guinea-pig and mouse. Acta Pharmacol Toxicol 49:8–13.

    Article  CAS  Google Scholar 

  • Stewart DL, Sass EJ, Fritz LK, Sasser LB (1989a) Toxicology studies on lewisite and sulfur mustard agents: mutagenicity of sulfur mustard in the Salmonella histidine reversion assay. PNL-6873 (DTIC: AD A213102). Pacific Northwest Laboratories. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD.

    Google Scholar 

  • Stewart DL, Sass EJ, Fritz LK, Sasser LB (1989b) Toxicology studies on lewisite and sulfur mustard agents: mutagenicity of lewisite in the Salmonella histidine reversion assay. PNL-6872. Pacific Northwest Laboratory, Richland, WA.

    Book  Google Scholar 

  • Sumerford WT, Hayes WJ, Johnston JM, Walker K, Spillane J (1953) Cholinesterase response and symptomatology from exposure to organic phosphorus insecticides. AMA Arch Ind Hyg Occup Med 7:383–398.

    CAS  PubMed  Google Scholar 

  • Switzer RC, Murphy MR, Campbell SK, Kerenyi SZ, Miller SA, Hartgraves SK (1989) Soman-induced damage to selected populations of neurons in rat and rhesus monkey brains. USAMRDC Med Def Biosci Rev:107–110. (Cited in Somani et al. 1992.)

    Google Scholar 

  • Takeshima Y, Inai K, Bennet WP, Metcalf RA, Welsh JA, Yonehara S, Hayashi Y, Fujihara M, Yamakido M, Akiyama M, Tokuoka S, Land CE, Harris CC (1994) P53 mutations in lung cancers from Japanese mustard gas workers. Carcinogenesis (Oxf) 15:2075–2079.

    Article  CAS  Google Scholar 

  • Tewe OO, Maner JH (1981a) Long-term and carry-over effect of dietary inorganic cyanide (KNC) in the life cycle performance and metabolism of rats. Toxicol App] Pharmacol 58:1–7.

    Article  CAS  Google Scholar 

  • Tewe OO, Maner JH (198lb) Performance and pathophysiological changes in pregnant pigs fed cassava diets containing different levels of cyanide. Res Vet Sci 30:147–151.

    Article  CAS  PubMed  Google Scholar 

  • Thienes CH, Haley TJ (1972) Clinical Toxicology. Lea & Febiger, Philadelphia, pp 95–115.

    Google Scholar 

  • Trammell GL (1992) Toxicodynamics of organoarsenic chemical warfare agents. In: Somani SM (ed) Chemical Warfare Agents. Academic Press, New York, pp 255–270.

    Google Scholar 

  • Trapp R (1985) The Detoxification and Natural Degradation of Chemical Warfare Agents. Taylor & Francis, London.

    Google Scholar 

  • Tripathi HL, Dewey WL (1989) Comparison of the effect of diisopropylfluorophosphate, sann, soman, and tabun on toxicity and brain acetylcholinesterase activity in mice. J Toxicol Environ Health 26:437–446. (Cited in Somani et al. 1991.)

    Article  CAS  PubMed  Google Scholar 

  • USACHPPM (1996) Detailed and general facts about chemical agents. TG218. U.S. Department of the Army, Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD.

    Google Scholar 

  • USACMDA (1993a) Interim survey and analysis report. Program Manager for Non-Stockpile Chemical Materiel, Nonstockpile Chemical Materiel Program, U.S. Department of the Army, Chemical Materiel Destruction Agency, Aberdeen Proving Ground, MD.

    Google Scholar 

  • USACMDA (1993b) Survey and analysis report. Program Manager for Non-Stockpile Chemical Materiel Program, U.S. Department of the Army, Chemical Materiel Destruction Agency, Aberdeen Proving Ground, MD.

    Google Scholar 

  • USAF (1989) Cyanide. In: The installation restoration program toxicology guide, vol 4. Oak Ridge National Laboratory, Oak Ridge, TN. Prepared for U.S. Air Force, Systems Command, Wright-Patterson Air Force Base, OH.

    Google Scholar 

  • USEPA (1984a) Health effects assessment for arsenic. EPA/540/1–86/120. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH.

    Google Scholar 

  • USEPA (1984b) Health effects assessment for cyanide. EPA/540/1–86–011. U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH. Prepared for the Emergency and Remedial Response Office, Washington, DC.

    Google Scholar 

  • USEPA (1985) Drinking water criteria document for cyanide. Final draft, EPA-600/X84–192–1; ECAO-CIN-442. U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH.

    Google Scholar 

  • USEPA (1988) Methodology for evaluating potential carcinogenicity in support of reportable quantity adjustments pursuant to CERCLA Section 102. OHEA-C-073, April, 1988. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • USEPA (1989) Risk assessment guidance for Superfund, vol 1. Human health evaluation manual (part A). EPA/540/1–89/002. U.S. Environmental Protection Agency, Office of Emergency and Remedial Response, Washington, DC.

    Google Scholar 

  • USEPA (1990a) Exposure factors handbook. EPA/600/8–89/043. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Washington DC.

    Google Scholar 

  • USEPA (1990b) Arsenic, inorganic: oral RfD summary. Integrated Risk Information System, on-line file. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, National Center for Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • USEPA (1991a) Upper-bound quantitative cancer risk estimate for populations adjacent to sulfur mustard incineration facilities. EPA/600/8–91/053. U.S. Environmental Protection Agency, Office of Research and Development, Washington, DC.

    Google Scholar 

  • USEPA (1991b) Oral RfD assessment for silver. Integrated Risk Assessment System (IRIS). Online file. U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • USEPA (1994a) Methods for the derivation of inhalation reference concentrations and application of inhalation dosimetry. EPA/600/8–90/066F. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, National Center for Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • USEPA (1994b) Arsenic, inorganic: cancer assessment. Verification date 02/03/94. Integrated Risk Information System, on-line file, retrieved April 10, 1997. U.S. Environmental Protection Agency, Office of Research and Development, Washington, DC.

    Google Scholar 

  • USEPA (1995a) Proposed guidelines for neurotoxicity risk assessment. Fed Reg 60: 52032–52056.

    Google Scholar 

  • USEPA (1995b) Oral RfD assessment for malathion. Integrated Risk Information System (IRIS), online file. U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • USEPA (1996a) Health effects assessment summary table: annual update. U.S. Environmental Protection Agency, Office of Emergency and Remedial Response, Washington, DC, and Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH.

    Google Scholar 

  • USEPA (1996b) Drinking water regulations and health advisories. U.S. Environmental Protection Agency, Office of Water, Washington, DC.

    Google Scholar 

  • USEPA (1996c) Proposed guidelines for carcinogen risk assessment. EPA/600/P-92/ 003C. U.S. Environmental Protection Agency, Office of Research and Development, Washington, DC.

    Google Scholar 

  • USEPA (1996d) Cyanogen chloride. Integrated Risk Information System (IRIS). U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • USEPA (1996e) Cyanide, free. Integrated Risk Information System (IRIS). U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • USEPA (1997) Integrated Risk Information System. On-line file. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, National Center for Environmental Assessment, Cincinnati, OH.

    Google Scholar 

  • van Dongen CJ, Wolthuis OL (1989) On the development of behavioral tolerance to organophosphates I: behavioral and biochemical aspects. Pharmacol Biochem Behav 34:473–481.

    Article  PubMed  Google Scholar 

  • Van Kampen KR, Shupe JL, Johnson AE, James LF, Smart RA, Rasmussen JE (1970) Effects of nerve gas poisoning in sheep in Skull Valley, UT. J Am Vet Med Assoc 156:1032–1035.

    PubMed  Google Scholar 

  • Venitt S (1968) Interstrand cross-links in the DNA of Escherichia coil B/r and Bs., and their removal by the resistant strain. Biochem Biophys Res Commun 31:355–360.

    Article  CAS  PubMed  Google Scholar 

  • Verschueren, K (1996) Handbook of Environmental Data on Organic Chemicals, 3rd Ed. Van Nostrand Reinhold, New York, pp 561–562.

    Google Scholar 

  • Verweij A, Boter HL (1976) Degradation of S-2-diisopropylaminoethyl 0-ethyl methyl-phosphonothioate in soil: phosphorus-containing products. Pestic Sci 7:355–362.

    Article  CAS  Google Scholar 

  • Vogt RF Jr, Dannenberg AM Jr, Schofield BH, Hynes NA, Papirmeister B (1984) Pathogenesis of skin lesions caused by sulfur mustard. Fundam Appl Toxicol 4:571–583.

    Article  Google Scholar 

  • Vojvodic V, Milosavjevic Z, Boskovic B, Bojanic N (1985) The protective effect of different drugs in rats poisoned by sulfur and nitrogen mustards. Fund Appl Toxicol 5:5160–5168.

    Article  Google Scholar 

  • Vranken MA, DeBisschop HC, Willems JL (1982) In vitro inhibition of neurotoxic ester-ase by organophosphorus nerve agents. Arch Int Pharmacodyn Ther 260:316–318.

    CAS  PubMed  Google Scholar 

  • Wada S, Nishimoto Y, Miyanashi M, Katsuta S, Nishiki M, Yamada A, Tokuoka S, Umisa H, Nagai M (1962a) Review of Okuno-jima poison gas factory regarding occupational environment. Hiroshima J Med Sci 11:75–80.

    Google Scholar 

  • Wada S, Nishimoto Y, Miyanshi M, Katsuta S, Nishiki M, Yamada A, Tokuoka S, Umisa H, Nagal M (1962b) Malignant respiratory tract neoplasms related to poison gas exposure. Hiroshima J Med Sci 11:81–91.

    Google Scholar 

  • Wada S, Miyanishi M, Nishimoto Y, Kambe S, Miller RM (1968) Mustard gas as a cause of respiratory neoplasm in man. Lancet 2:1161–1163.

    Article  Google Scholar 

  • Walker IG, Thatcher CJ (1968) Lethal effects of sulfur mustard on dividing mammalian cells. Radiat Res 34:110–127.

    Article  CAS  PubMed  Google Scholar 

  • Wall HG, Jaax NK, Hayward 1J (1990) Motor activity and brain lesions in soman intoxicated rhesus monkeys. DTIC: ADA222912. Proceedings, Workshop on Convulsions and Related Brain Damage Induced by Organophosphorus Agents. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, pp 21–29. (Cited in Baze 1993.)

    Google Scholar 

  • Ward DM, Anson NM, Parent PA, Enquist EH (1966) Sulfur mustard and analogous compounds as special purpose agents (U). EASP 100–7R1,100–7. U.S. Department of the Army, Aberdeen Proving Ground, MD. (Cited in Rosenblatt et al. 1975.)

    Google Scholar 

  • Wardell EL (1941) Lewisite (M-1): 1940 summary of physiologic and toxicologic data Rep EATR 285 (DTIC: AD B959553L). U.S. Department of the Army, Chemical Warfare Service, Edgewood Arsenal, MD.

    Google Scholar 

  • Waters MD, Garrett NE, Covone deSerres CM, Howard BE, Stack HF (1983) Genetic toxicology of some known or suspected human carcinogens. In: de Serres FJ (ed) Chemical Mutagens: Principles and Methods for Their Detection, vol 8. Plenum Press, New York, pp 261–341.

    Chapter  Google Scholar 

  • Watson AP, Griffin GD (1992) Toxicity of vesicant agents scheduled for destruction by the chemical stockpile disposal program. Environ Health Perspect 98:259–280.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Watson AP, Jones TD, Griffin GD (1989a) Sulfur mustard as a carcinogen: application of relative potency analysis to the chemical warfare agents H, HD, and HT. Regul Toxicol Pharmacol 10:1–25.

    Article  CAS  PubMed  Google Scholar 

  • Watson AP, Ambrose KR, Griffin GD, Leffingwell SS, Munro NB, Waters LC (1989b) Health effects of warfare agent exposure: implications for stockpile disposal. Environ Prof 11:335–353.

    Google Scholar 

  • Watson AP, Adams JD, Cerar RJ, Hess TL, Kistner SL, Leffingwell SS, McIntosh RG, Ward JR (1992) Estimated general population control limits for unitary agents in drinking water, milk, soil, and unprocessed food items. ORNL/TM-12035. Oak Ridge National Laboratory, Oak Ridge, TN.

    Book  Google Scholar 

  • Weimer JT, Owens EJ, Samuel JB, Olsson JS, Merkey RP (1970) Toxicity of VX and GD in aquatic animals indigenous to the Carroll Island test area water. Tech Rep 4441. U.S. Department of the Army, Edgewood Arsenal, MD.

    Google Scholar 

  • Weimer JT, McNamara BP, Owens EJ, Cooper JG, Van de Wal A (1979) Proposed revision of limits for human exposure to GB vapor in nonmilitary operations based on one-year exposures of laboratory animals to low airborne concentrations. ARCSLTR-78056. U.S. Department of the Army, Armament Research and Development Command, Chemical Systems Laboratory, Aberdeen Proving Ground, MD.

    Google Scholar 

  • Weiss A, Weiss B (1975) Karzinogenese durch Lost-Exposition beim Menschen, ein wichtiger Hinweis fur die alkylantien-Therapie. Dtsch Med Wochenschr 100:919–923 (Cited in IARC 1975.)

    Article  CAS  PubMed  Google Scholar 

  • Weiss CM, Botts JL (1957) The response of some freshwater fish to isopropyl methylphosphonofluoridate (sarin) in water. Limnol Oceanogr 2:363–370.

    Article  Google Scholar 

  • Weiss G (ed) (1980) Hazardous Chemicals Data Book. Noyes Data Corporation, Park Ridge, NJ, p 288.

    Google Scholar 

  • Westley J (1980) Rhodanese and sulfane pool. In: Enzymatic Basis of Detoxication, vol II. Academic Press, New York, pp 245–262.

    Chapter  Google Scholar 

  • WHO (1970) Chemical agents. In: Health Aspects of Chemical and Biological Weapons. World Health Organization, Geneva, pp 23–31.

    Google Scholar 

  • WHO (1981) Arsenic. Environmental Health Criteria, vol 18. IPCS International Program on Chemical Safety, World Health Organization, Geneva.

    Google Scholar 

  • Willems JL, Nacaise M, De Bisschop HC (1984) Delayed neuropathy by the organophosphorus nerve agents roman and tabun. Arch Toxicol 55:76–77.

    Article  CAS  PubMed  Google Scholar 

  • Wills JH (1972) The measurement and significance of changes in the cholinesterase activities of erythrocytes and plasma in man and animals. CRC Crit Rev Toxicol 1: 153–202.

    Article  Google Scholar 

  • Wilson BW, Henderson JD, Kelner TP, Goldman M, Higgins RJ, Dacre JC (1988) Toxicity of repeated doses of organophosphorus esters in the chicken. J Toxicol Environ Health 23:115–126.

    Article  CAS  PubMed  Google Scholar 

  • Wilson BW, Kawakami TG, Cone N, Henderson JD, Rosenblatt LS, Goldman M (1994) Genotoxicity of the phosphoramidate agent tabun (GA). Toxicology 86:1–12.

    Article  CAS  PubMed  Google Scholar 

  • Wilson IB, Sondheimer F (1957) A specific antidote against lethal alkyl phosphate intoxication. Arch Biochem 69:468–471.

    Article  CAS  PubMed  Google Scholar 

  • Windholz M, Budavari S, Blumetti RF, Otterbein ES (eds) (1983) The Merck Index, 10th Ed. Merck, Rahway, NJ.

    Google Scholar 

  • Wolthuis OL (1992) Behavioral effects of low doses of cholinesterase inhibitors in robot-tested marmosets. DTIC: AD A262776. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD. TNO Medical Biological Laboratory, Rijswijk, Netherlands.

    Google Scholar 

  • Wolthuis OL, Philippens IH, Vanwersch R (1990) On the development of behavioral tolerance to organophosphates. III: Behavioral aspects. Pharmacol Biochem Behav 35:561–565.

    Article  CAS  PubMed  Google Scholar 

  • Woodard CL, Calamaio CA, Kaminskis A, Anderson DR, Harris LW, Martin DG (1994) Erythrocyte and plasma cholinesterase activity in male and female rhesus monkeys before and after exposure to sann. Fundam Appl Toxicol 23:342–347.

    Article  CAS  PubMed  Google Scholar 

  • Working PK (1988) Male reproductive toxicology: comparison of the human to animal models. Environ Health Perspect 77:37–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Worthley EG (1970) The toxicity of VX to various plants. Tech Memo, EATM 100–9. U.S. Department of the Army, Edgewood Arsenal, MD. (Cited in DA 1988.)

    Google Scholar 

  • Wulf HC, Aasted A, Darre E, Niebuhr E (1985) Sister chromatid exchanges in fishermen exposed to leaking mustard gas shells. Lancet 1:690–691.

    Article  CAS  PubMed  Google Scholar 

  • Yager J, McLean H, Hudes M, Spear RC (1976) Components of variability in blood cholinesterase assay results. J Occup Med 18:242–244.

    CAS  PubMed  Google Scholar 

  • Yamada A (1963) On the late injuries following occupational inhalation of mustard gas, with special references to carcinoma of the respiratory tract. Acta Pathol Jpn 13: 131–155.

    CAS  PubMed  Google Scholar 

  • Yamada A (1974) Patho-anatomical studies on occupational poisoning. Trans Jpn Pathol Soc 63:17–61. (Cited in Inada et al. 1978.)

    Google Scholar 

  • Yamada A, Hirose F, Miyanishi M (1953) An autopsy of bronchial carcinoma found in a patient succumbed to occupational mustard gas poisoning. Gann 44:216–219. (Cited in IARC 1975.)

    CAS  PubMed  Google Scholar 

  • Yamada A, Hirose F, Nagai M, Nakamura T (1957) Five cases of cancer of the larynx found in persons who suffered from occupational mustard gas poisoning. Gann 48: 366–368. (Cited in IARC 1975.)

    CAS  PubMed  Google Scholar 

  • Yamakido M, Nishimoto Y, Shigenobu T, Onari K, Satoh C, Goriki K, Fujita M (1985) Study of the genetic effects of sulfur mustard gas on former workers on Okuno-jima poison gas factory and their offspring. Hiroshima J Med Sci 24:311–322.

    Google Scholar 

  • Yamakido M, Ishioka S, Hiyama K, Maeda A (1996) Former poison gas workers and cancer: incidence and inhibition of tumor formation by treatment with biological response modifier N-CWS. Environ Health Perspect 104:485–488.

    PubMed  PubMed Central  Google Scholar 

  • Yanagida J, Hozawa S, Ishioka S, Maeda H, Takahashi K, Oyama T, Takaishi M, Hakoda M, Akiyma M, Yamakido M (1988) Somatic mutation in peripheral lymphocytes of former workers at the Okunojima poison gas factory. Jpn J Cancer Res 79: 1276–1283.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang Y, Szafraniec LL, Beaudry WT, Rohrbaugh DK (1990) Oxidative detoxification of phosphonothiolates. J Am Chem Soc 112:6621–6627.

    Article  CAS  Google Scholar 

  • Yang Y-C, Baker JA, Ward JR (1992) Decontamination of chemical warfare agents. Chem Rev 92:1729–1743.

    Article  CAS  Google Scholar 

  • Zackheim HS, Smuckler EA (1980) Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice. Experientia (Basel) 36:6.

    Article  Google Scholar 

  • Zhao D-L, Wang Z-X, Pei S-Q, Liu C-H (1983) Effects of soman, sann and VX on the specific binding of 3H-QNB in rat cerebral cortex homogenates. Acta Pharmacol Sin 4:225–228.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Opresko, D.M. et al. (1998). Chemical Warfare Agents: Estimating Oral Reference Doses. In: Ware, G.W. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 156. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1722-0_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1722-0_1

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7255-7

  • Online ISBN: 978-1-4612-1722-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics