市販の大麻種子中のカンナビノイドの定量とその薬毒理作用

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書誌事項

タイトル別名
  • Quantitative Analysis and Pharmaco-Toxicity of Cannabinoids in Commercially Available Cannabis Seeds
  • シハン ノ タイマ シュシ チュウ ノ カンナビノイド ノ テイリョウ ト ソ

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抄録

△9-Tetrahydrocannabinol (△9-THC), cannabinol, cannabidiol and cannabichromene were detected in commercially available cannabis seeds by silica gel TLC and gas chromatography. These cannabinoids existed in rather high content (0.10-2.02mg/100g of seeds) in the feed for birds, especially bracts (82.3-441mg/100g). When the suspension prepared from the benzene washing solution of cannabis seeds, BenW, was administered at a dose of 3mg/kg corresponding to △9-THC into a mouse, i.v., BenW caused hypothermia, catalepsy, pentobarbital-induced sleep prolongation and suppression of locomotor activity. These pharmacological activities of BenW were significantly higher than those of △9-THC (3mg/kg, i.v.). These results may indicate the necessity to reconsider the present regulations on marihuana.

収録刊行物

  • 薬学雑誌

    薬学雑誌 118 (9), 408-414, 1998

    公益社団法人 日本薬学会

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