フェリチン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/03/16 10:23 UTC 版)
フェリチン（Ferritin）とは、鉄結合性タンパク質の一種である。生物の細胞内において、鉄と結合することにより鉄を保存し、必要なときに鉄を放出する。藻類、細菌、高等植物、ヒト、動物を含むほぼすべての生物がフェリチンを合成する。ヒトにおいては鉄不足と鉄過剰を抑える役割を持つ[3]。フェリチンはほとんどの組織の細胞質に存在するが、一部は鉄運搬体として血漿中に分泌されている。血漿フェリチンの量は、肉体に蓄積されている鉄の総量の推計指標であり、鉄欠乏性貧血の診断材料である[4]。
- ^ ; Granier T, Langlois d'Estaintot B, Gallois B, Chevalier JM, Précigoux G, Santambrogio P, Arosio P (January 2003). "Structural description of the active sites of mouse L-chain ferritin at 1.2 A resolution". Journal of Biological Inorganic Chemistry. 8 (1–2): 105–11. doi:10.1007/s00775-002-0389-4. PMID 12459904。
- ^ PDB: 1r03; Langlois d'Estaintot B, Santambrogio P, Granier T, Gallois B, Chevalier JM, Précigoux G, Levi S, Arosio P (July 2004). "Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala". Journal of Molecular Biology. 340 (2): 277–93. doi:10.1016/j.jmb.2004.04.036. PMID 15201052。
- ^ Iron Use and Storage in the Body: Ferritin and Molecular Representations, Rachel Casiday and Regina Frey, Department of Chemistry, Washington University, St. Louis.
- ^ Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV (August 2010). "Serum ferritin: Past, present and future". Biochimica et Biophysica Acta. 1800 (8): 760–9. doi:10.1016/j.bbagen.2010.03.011. PMC 2893236. PMID 20304033。
- ^ a b c Theil, Elizabeth C. (2012). “Ferritin protein nanocages—the story”. Nanotechnology Perceptions 8: 7–16. doi:10.4024/N03TH12A.ntp.08.01.
- ^ Torti FM, Torti SV (May 2002). "Regulation of ferritin genes and protein". Blood. 99 (10): 3505–16. doi:10.1182/blood.V99.10.3505. PMID 11986201。
- ^ a b c d e f Theil EC (1987). "Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms". Annual Review of Biochemistry. 56 (1): 289–315. doi:10.1146/annurev.bi.56.070187.001445. PMID 3304136。
- ^ De Zoysa M, Lee J (September 2007). "Two ferritin subunits from disk abalone (Haliotis discus discus): cloning, characterization and expression analysis". Fish & Shellfish Immunology. 23 (3): 624–35. doi:10.1016/j.fsi.2007.01.013. PMID 17442591。
- ^ FERRITIN STRUCTURE AND ITS BIOMEDICAL IMPLICATIONS
- ^ a b c d e f g h Andrews SC, Arosio P, Bottke W, Briat JF, von Darl M, Harrison PM, Laulhère JP, Levi S, Lobreaux S, Yewdall SJ (1992). "Structure, function, and evolution of ferritins". Journal of Inorganic Biochemistry. 47 (3–4): 161–74. doi:10.1016/0162-0134(92)84062-R. PMID 1431878。
- ^ a b “検査部/輸血部インフォメーション”. 岡山大学. 2017年10月15日閲覧。
- ^ Zhang Y, Meng Q, Jiang T, Wang H, Xie L, Zhang R (May 2003). "A novel ferritin subunit involved in shell formation from the pearl oyster (Pinctada fucata)". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 135 (1): 43–54. doi:10.1016/S1096-4959(03)00050-2. PMID 12781972。
- ^ Levi S, Corsi B, Bosisio M, Invernizzi R, Volz A, Sanford D, Arosio P, Drysdale J (July 2001). "A human mitochondrial ferritin encoded by an intronless gene". The Journal of Biological Chemistry. 276 (27): 24437–40. doi:10.1074/jbc.C100141200. PMID 11323407。
- ^ Seckback J (1982). "Ferreting out the secrets of plant ferritin - A review". Journal of Plant Nutrition. 5 (4–7): 369–394. doi:10.1080/01904168209362966。
- ^ Orino K, Lehman L, Tsuji Y, Ayaki H, Torti SV, Torti FM (July 2001). "Ferritin and the response to oxidative stress". The Biochemical Journal. 357 (Pt 1): 241–7. doi:10.1042/0264-6021:3570241. PMC 1221947. PMID 11415455。
- ^ Jackson DJ, Wörheide G, Degnan BM (2007). "Dynamic expression of ancient and novel molluscan shell genes during ecological transitions". BMC Evolutionary Biology. 7: 160. doi:10.1186/1471-2148-7-160. PMC 2034539. PMID 17845714。
- ^ Yano M, Nagai K, Morimoto K, Miyamoto H (June 2006). "Shematrin: a family of glycine-rich structural proteins in the shell of the pearl oyster Pinctada fucata". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 144 (2): 254–62. doi:10.1016/j.cbpb.2006.03.004. PMID 16626988。
- ^ Kyung-Suk K, Webb J, Macey D (1986). "Properties and role of ferritin in the hemolymph of the chiton Clavarizona hirtosa". Biochimica et Biophysica Acta (BBA) - General Subjects. 884 (3): 387–394. doi:10.1016/0304-4165(86)90188-1。
- ^ Zhang, Y., Mikhael, M., Xu, D., Li, Y., Soe-Lin, S., Ning, B., ... & Ponka, P. (2010). Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit. Antioxidants & redox signaling, 13(7), 999-1009.
- ^ a b c Honarmand Ebrahimi K, Hagedoorn PL, Hagen WR (January 2015). "Unity in the biochemistry of the iron-storage proteins ferritin and bacterioferritin". Chemical Reviews. 115 (1): 295–326. doi:10.1021/cr5004908. PMID 25418839。
- ^ a b Honarmand Ebrahimi K, Bill E, Hagedoorn PL, Hagen WR (November 2012). "The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement". Nature Chemical Biology. 8 (11): 941–8. doi:10.1038/nchembio.1071. PMID 23001032。
- ^ Watt RK (March 2013). "A unified model for ferritin iron loading by the catalytic center: implications for controlling "free iron" during oxidative stress". Chembiochem. 14 (4): 415–9. doi:10.1002/cbic.201200783. PMID 23404831。
- ^ Carmona U, Li L, Zhang L, Knez M (December 2014). "Ferritin light-chain subunits: key elements for the electron transfer across the protein cage". Chemical Communications. 50 (97): 15358–61. doi:10.1039/c4cc07996e. PMID 25348725。
- ^ 河合忠「異常値の出るメカニズム」医学書院 ISBN 978-4260016568
- ^ a b Ong DS, Wang L, Zhu Y, Ho B, Ding JL (2005). "The response of ferritin to LPS and acute phase of Pseudomonas infection". Journal of Endotoxin Research. 11 (5): 267–80. doi:10.1179/096805105X58698. PMID 16262999。
- ^ Larade K, Storey KB (March 2004). "Accumulation and translation of ferritin heavy chain transcripts following anoxia exposure in a marine invertebrate". The Journal of Experimental Biology. 207 (Pt 8): 1353–60. doi:10.1242/jeb.00872. PMID 15010486。
- ^ Beck G, Ellis TW, Habicht GS, Schluter SF, Marchalonis JJ (January 2002). "Evolution of the acute phase response: iron release by echinoderm (Asterias forbesi) coelomocytes, and cloning of an echinoderm ferritin molecule". Developmental and Comparative Immunology. 26 (1): 11–26. doi:10.1016/S0145-305X(01)00051-9. PMID 11687259。
- ^ a b Bottke W, Burschyk M, Volmer J (1988). "On the origin of the yolk protein ferritin in snails". Roux's Archives of Developmental Biology. 197 (7): 377–382. doi:10.1007/BF00398988。
- ^ “Ferritin”. WebMD (2020年). 2016年10月27日閲覧。
- ^ 日本鉄バイオサイエンス学会治療指針作成委員会『鉄剤の適正使用による貧血治療指針』（改訂第3版）響文社、2015年、22-26頁。ISBN 9784877991142。 NCID BB20559542。全国書誌番号:22755223。
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- ^ 岸本 美也子ほか、「4．鉄過剰と膵障害・糖尿病」『日本内科学会雑誌』第99巻6号、2010年、1255-1260頁、doi:10.2169/naika.99.1255。
- ^ Kasyutich O, Ilari A, Fiorillo A, Tatchev D, Hoell A, Ceci P (March 2010). "Silver Ion Incorporation and Nanoparticle Formation inside the Cavity ofPyrococcus furiosusFerritin Structural and Size-Distribution Analyses". J. Am. Chem. Soc. 132 (10): 3621–7. doi:10.1021/ja910918b. PMID 20170158。
- ^ Uchida M, Flenniken ML, Allen M, Willits DA, Crowley BE, Brumfield S, Willis AF, Jackiw L, Jutila M, Young MJ, Douglas T (December 2006). "Targeting of Cancer Cells with Ferrimagnetic Ferritin Cage Nanoparticles". Journal of the American Chemical Society. 128 (51): 16626–33. doi:10.1021/ja0655690. PMID 17177411。
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[続きの解説]
「フェリチン」の続きの解説一覧
- 1 フェリチンとは
- 2 フェリチンの概要
- 3 生体内分布
- 4 外部リンク
- フェリチンのページへのリンク
