ピオベルジン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/11/28 08:24 UTC 版)
ピオベルジン（Pyoverdines、稀にpyoverdins、Pvd)とは、水溶性の黄緑の蛍光性色素の一種である化学物質である[1]。ある種のシュードモナス属菌種によって産生される蛍光性シデロホアの一種であり[2][3]、重要な病原性因子の一つである。産生主である病原菌に向けて、栄養素（鉄など）の供給、産生主の病原性因子（菌体外毒素Aやタンパク質分解酵素PrpLなど）の制御[4]、バイオフィルムの形成の援助[5]、および毒性の強化[6][7][8]といった役割を持つ。
- ^ a b Jean-Marie Meyer (Sep 2000). “Pyoverdines: pigments, siderophores and potential taxonomic markers of fluorescent Pseudomonas species”. Archives of Microbiology 174 (3). doi:10.1007/s002030000188. PMID 11041343.
- ^ S. Wendenbaum; P. Demange; A. Dell; J. M. Meyer; M. A. Abdallah (1983). “The structure of pyoverdine Pa, the siderophore of Pseudomonas aeruginosa”. Tetrahedron Letters 24 (44): 4877–4880. doi:10.1016/S0040-4039(00)94031-0.
- ^ Menhart, N.; Thariath, A.; Viswanatha, T. (1991). “Characterization of the pyoverdines of Azotobacter vinelandii ATCC 12837 with regard to heterogeneity”. Biology of Metals 4 (4): 223–32. doi:10.1007/bf01141185.
- ^ Lamont, Iain L.; Beare, Paul A.; Ochsner, Urs; Vasil, Adriana I.; Vasil, Michael L. (2002-05-14). “Siderophore-mediated signaling regulates virulence factor production in Pseudomonasaeruginosa”. Proceedings of the National Academy of Sciences of the United States of America 99 (10): 7072–7077. doi:10.1073/pnas.092016999. ISSN 0027-8424. PMC 124530. PMID 11997446.
- ^ Banin, Ehud; Vasil, Michael L.; Greenberg, E. Peter (2005-08-02). “Iron and Pseudomonas aeruginosa biofilm formation”. Proceedings of the National Academy of Sciences of the United States of America 102 (31): 11076–11081. doi:10.1073/pnas.0504266102. ISSN 0027-8424. PMC 1182440. PMID 16043697.
- ^ Kirienko, Natalia V.; Kirienko, Daniel R.; Larkins-Ford, Jonah; Wählby, Carolina; Ruvkun, Gary; Ausubel, Frederick M. (2013-04-17). “Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death”. Cell Host & Microbe 13 (4): 406–416. doi:10.1016/j.chom.2013.03.003. ISSN 1934-6069. PMC 3641844. PMID 23601103.
- ^ Kirienko, Natalia V.; Ausubel, Frederick M.; Ruvkun, Gary (2015-02-10). “Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa”. Proceedings of the National Academy of Sciences of the United States of America 112 (6): 1821–1826. doi:10.1073/pnas.1424954112. ISSN 1091-6490. PMC 4330731. PMID 25624506.
- ^ Minandri, Fabrizia; Imperi, Francesco; Frangipani, Emanuela; Bonchi, Carlo; Visaggio, Daniela; Facchini, Marcella; Pasquali, Paolo; Bragonzi, Alessandra et al. (2016-08-01). “Role of Iron Uptake Systems in Pseudomonas aeruginosa Virulence and Airway Infection”. Infection and Immunity 84 (8): 2324–2335. doi:10.1128/IAI.00098-16. ISSN 1098-5522. PMC 4962624. PMID 27271740.
- ^ Agnieszka Górska, Anna Sloderbach, Michał Piotr Marszałł (Sep 2014). “Siderophore–drug complexes: potential medicinal applications of the ‘Trojan horse’ strategy”. Trends in Pharmacological Sciences 35 (9): 442-449. doi:10.1016/j.tips.2014.06.007.
- ^ J. Y. Cornu, M. Elhabiri, C. Ferret, V. A. Geoffroy, K. Jezequel, Y. Leva, M. Lollier, I. J. Schalk, T. Lebeau (May 2014). “Contrasting effects of pyoverdine on the phytoextraction of Cu and Cd in a calcareous soil”. Chemosphere 103: 212-219. doi:10.1016/j.chemosphere.2013.11.070.
- ^ Yoder, Michael F.; Kisaalita, William S. (2011-01-01). “Iron specificity of a biosensor based on fluorescent pyoverdin immobilized in sol-gel glass”. Journal of Biological Engineering 5: 4. doi:10.1186/1754-1611-5-4. ISSN 1754-1611.
- ^ M Jean-Marie, G Valérie (2005). “Analyzing Pseudomonas biodiversity: An easy challenge thanks to siderophore typing”. In T. Satyanarayana、B. N. Johr. Microbial Diversity: Current Perspectives and Potential Applications. I. K. International Pvt Ltd. pp. 311-313
- ^ Hohlneicher, U.; Schäfer, M.; Fuchs, R.; Budzikiewicz, H. (2016-10-11). “Ferribactins as the biosynthetic precursors of the Pseudomonas siderophores pyoverdins”. Zeitschrift für Naturforschung C 56 (3–4): 308–310. ISSN 0939-5075. PMID 11371026.
- ^ Visca, Paolo; Imperi, Francesco; Lamont, Iain L. (2007-01-01). “Pyoverdine siderophores: from biogenesis to biosignificance”. Trends in Microbiology 15 (1): 22–30. doi:10.1016/j.tim.2006.11.004. ISSN 0966-842X. PMID 17118662.
- ^ Budzikiewicz, H (1997). “Siderophores of Fluorescent Pseudomonads”. Zeitschrift für Naturforschung C 52 (11–12): 713–720.
- ^ Meyer, J. M. (2000). “Pyoverdines: Pigments, siderophores and potential taxonomic markers of fluorescent Pseudomonas species”. Archives of Microbiology 174 (3): 135–142. doi:10.1007/s002030000188. PMID 11041343.
- ^ a b Ravel J, Cornelis P (May 2003). “Genomics of pyoverdine-mediated iron uptake in pseudomonads”. Trends in Microbiology 11 (5): 195-200. doi:10.1016/S0966-842X(03)00076-3. PMID 12781517.
- ^ a b Lamont, I. L. (2003). “Identification and characterization of novel pyoverdine synthesis genes in Pseudomonas aeruginosa”. Microbiology 149 (4): 833–842. doi:10.1099/mic.0.26085-0.
- ^ Imperi, Francesco; Massai, Francesco; Facchini, Marcella; Frangipani, Emanuela; Visaggio, Daniela; Leoni, Livia; Bragonzi, Alessandra; Visca, Paolo (2013-04-30). “Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity”. Proceedings of the National Academy of Sciences of the United States of America 110 (18): 7458–7463. doi:10.1073/pnas.1222706110. ISSN 1091-6490. PMC 3645532. PMID 23569238.
- ^ Kirienko, Daniel R. (2016-08-01). “A High-Content, Phenotypic Screen Identifies Fluorouridine as an Inhibitor of Pyoverdine Biosynthesis and Pseudomonas aeruginosa Virulence”. mSphere 1 (4): e00217-16. doi:10.1128/mSphere.00217-16. ISSN 2379-5042. PMC 4999921. PMID 27579370.
- ^ Cornelis, P (1989). “Evidence for different pyoverdine-mediated iron uptake systems among Pseudomonas aeruginosa strains”. Infect Immun 57 (11): 3491–3497.
- ^ Hohnadel, Dany (1986-09-01). “Mapping of mutations affecting pyoverdine production in Pseudomonas aeruginosa” (英語). FEMS Microbiology Letters 36 (2–3): 195–199. doi:10.1111/j.1574-6968.1986.tb01695.x. ISSN 0378-1097.
- ^ Stintzi, A. (1999-07-01). “The pvc gene cluster of Pseudomonas aeruginosa: role in synthesis of the pyoverdine chromophore and regulation by PtxR and PvdS”. Journal of Bacteriology 181 (13): 4118–4124. ISSN 0021-9193. PMC 93907. PMID 10383985.
- ^ Clarke-Pearson, Michael F.; Brady, Sean F. (2008-10-01). “Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa”. Journal of Bacteriology 190 (20): 6927–6930. doi:10.1128/JB.00801-08. ISSN 1098-5530. PMC 2566218. PMID 18689486.
- ^ Stintzi, A (1996). “Novel pyoverdine biosynthesis gene(s) of Pseudomonas aeruginosa PAO”. Microbiology 142 (5): 1181–1190. doi:10.1099/13500872-142-5-1181. PMID 8704959.
- ^ Cézard, C.; Farvacques, N.; Sonnet, P. (2015-01-01). “Chemistry and biology of pyoverdines, Pseudomonas primary siderophores”. Current Medicinal Chemistry 22 (2): 165–186. doi:10.2174/0929867321666141011194624. ISSN 1875-533X. PMID 25312210.
- ^ Mashiach, Roi (2013-04-05). “Total synthesis of pyoverdin D”. Organic Letters 15 (7): 1702–1705. doi:10.1021/ol400490s. ISSN 1523-7052. PMID 23530778.
- ^ Takase, H. (2000-04-01). “Impact of siderophore production on Pseudomonas aeruginosa infections in immunosuppressed mice”. Infection and Immunity 68 (4): 1834–1839. doi:10.1128/iai.68.4.1834-1839.2000. ISSN 0019-9567. PMC 97355. PMID 10722571.
- ^ Paolo Visca, F. Imperi, Iain L. Lamont (Jun 2007). “Pyoverdine siderophores: from biogenesis to biosignificance”. Trends Microbiology 15 (1): 22-30. doi:10.1016/j.tim.2006.11.004. PMID 17118662.
- ^ Mary E. Peek, Abhinav Bhatnagar, Nael A. McCarty, and Susu M. Zughaier (2012). “Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition”. Interdisciplinary Perspectives on Infectious Diseases 2012: 10. doi:10.1155/2012/843509. PMC 3438788. PMID 22973307.
- ^ Becerra, C. (2001-07-13). “Leukotoxicity of Pyoverdin, Production of Reactive Oxygen Species, and Effect of UV Radiation”. Biochemical and Biophysical Research Communications 285 (2): 414–418. doi:10.1006/bbrc.2001.5188. PMID 11444858.
[続きの解説]
「ピオベルジン」の続きの解説一覧
- 1 ピオベルジンとは
- 2 ピオベルジンの概要
- 3 化学合成
- ピオベルジンのページへのリンク
