Frequency of anti-nuclear antibodies in multiple sclerosis

Neurology. 1995 Feb;45(2):384-5. doi: 10.1212/wnl.45.2.384.

Abstract

We found anti-nuclear antibodies (ANA) in 26.7% of 150 relapsing-remitting and in 30.4% of 23 chronic progressive definite multiple sclerosis (MS) patients by retrospective chart review. These patients did not have systemic lupus erythematosus. Since ANA are not pathogenically relevant in MS, they are false-positive, and likely reflect systemic immune dysregulation in MS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Antibodies, Antinuclear / blood*
  • False Positive Reactions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / immunology*
  • Multiple Sclerosis / physiopathology
  • Retrospective Studies
  • Sex Characteristics
  • Sex Factors

Substances

  • Antibodies, Antinuclear